Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"disulfides"”.
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ELECTROCHEMICAL REDUCTION OF CYCLIC AND ACYCLIC BENZYL DISULFIDES
… (ET) to a series of cyclic and acyclic benzyl disulfides, compounds containing an S-S bond, were studied in N,N-dimethylformamide using the heterogeneous electrochemical techniques of cyclic voltammetry and coulometry. The cyclic disulfides were substituted 2,3- benzodithiin molecules and the …
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Synthesis and inclusion studies of stable allicin mimics as novel antimicrobial agents
… a new methodology for synthesizing unsymmetrical disulfides. The synthesis involves converting a thiol to a sulfenylating agent by 1-chlorobenzotriazole (BtCl) in the presence of 1,2,3-benzotriazole (BtH). Addition of a second thiol affords unsymmetrical disulfides in excellent yields. In addition …
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Synthesis Of Oligosaccharide Mimetics By The Desulfurative Rearrangement Of Allylic Disulfides And Stereoelectronic Influence Of C-O Bonds On C- And O-Glycosylation
… by the desulfurative rearrangement of allylic disulfides.</p> <p>The first part of chapter three presents the general mechanistic aspects of O-glycosylation reactions, before detailing them further in the context of glycosylation reactions using 4,6-O-benzylidene-protected donors. The second …
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The Mechanisms of Sulfur-Containing Metal Complexes as Uv-Stabilisers
… molar ratios, the First process predominates. Disulfides derived from the above complexes were found to be the initial oxidative products of the metal dithiolates and these were also investigated. The main mechanism of their antioxidant action involves the decomposition of hydroperoxides …
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Functional Importance of Oxidative Post-Translational Modifications of Ryanodine Receptor in Cardiac Sarcoplasmic Reticulum Ca2+ Handling During Oxidative Stress
… disease, is the prominence of glutathione mixed-disulfides as a result of oxidative stress. This work tests the hypothesis: Increased glutathione mixed-disulfides will promote oxidation of RyR2, promoting augmentation of SR Ca2+ fractional release and SR Ca2+ will leak. Oxidative PTMs of RyR2, …
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Peptide/Protein Stapling and Unstapling: Introduction and Photorelease of Isobutylene Graft
… on large biomolecules by re-bridging their disulfides. At the same time, the handle introduced by the method provides further opportunities for manipulating the bioactivity of the molecule. The first part of this work describes a new peptide-macrocyclisation strategy with an isobutylene …
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An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
… between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.
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UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY
… are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. …
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Synthesis and electron spin resonance spectroscopy of organo-sulfur radical cations
… the 1,4-benzodithiin radical cations. Diaryl disulfides underwent oxidative rearrangement to form benzodithiete and thianthrene radical cations. Methylbenzyl disulfides underwent oxidative rearrangement to form polymethylbenzodithiete and 2,6-dimethylanthrancene radical cations.</p>
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Fluorinated Metallo Phthalocyanines for Chemical and Biological Catalysis
… for example, the aerobic oxidation of thiols to disulfides, a reaction of both biological significance and industrial importance.</p> <p>The presence of robust C-F bonds, however, renders the catalyst unsuitable for attachment to solid-state supports, except via van der Waals bonds or via the …
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Redox Regulation of Type Iα PKA in the Heart
… protein kinase (PKA) form interprotein disulfides during oxidative stress which is associated with kinase activation. PKA classical activation involves cAMP binding to the regulatory subunits causing release of catalytic subunits which phosphorylate substrates. Presence of substrate …
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Design of High Efficiency Fibers for Ion Exchange and Heavy Metal Removal
… aspects of naturally occurring thiols and disulfides was used to draw parallels to observations found with the polyvinyl alcohol mercaptyl system and its reactivity towards arsenite. The ability of these systems to chelate arsenite was presented through equilibrium adsorption isotherms. All …
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The role of ERO1 in oxidative protein folding in the endoplasmic reticulum
… is indicated by the capture of PD1-Ero1p mixed-disulfides. PDI oxidizes secretory proteins, since newly-synthesized CPY remains fully reduced in POI-depleted cells. Mixed-disulfides between PDI and p1 CPY are also detected, indicating that PDI engages directly in thiol-disulfide exchange with …
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Thiol-Disulfide Exchange in Human Growth Hormone
… formulations that contain free cysteines and disulfides.
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Graphene-based Hybrid Electrodes for High-Performance Supercapacitors
… material (e.g., transition metal oxides/metal disulfides such as TMOs and TMDs). The SC component undergoes the electrostatic mode of charge storage by the formation of an EDL interface. Whereas the PC component provides the faradic mode of charge storage (in addition to the EDL layer). …
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Development of Dual-Electrode Amperometric Detectors for Liquid Chromatography and Capillary Electrophoresis
… capillary electrophoresis, in which thiols and disulfides were investigated in vivo. With the developed dual Au/Hg electrode redox changes were observed as a result of chemically induced oxidative stress.
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Electrochemical Detection of Aliphatic Sulfur Compounds in Liquid Coal Extracts
… such as sulfides, aliphatic thiols, and disulfides were studied using reverse phase HPLC with electrochemical detection in a acetonitrile/water mobile phase. Coal samples IBC 101 and IBC 105 were extracted with THF and hexane. The liquid coal extracts were fractionated using a simple …
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Characterization of Bioreducible Poly(B-amino Ester) Nanoparticles for siRNA Delivery
… efficacy. We hypothesized that the addition of disulfides to the main backbone of PBAE NPs would reduce cytotoxicity and increase siRNA transfection efficacy. Glutathione, a reducing agent present in the cytosol, can reduce a disulfide bond into two thiols and thus increase NP degradability for …
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A Lewis Acidic Stroll Through the p-Block
… acted as an FLP to effect the cleavage of disulfides. Phosphorus(V) dications containing both an ortho-quinone and terpyridine backbone were prepared and shown to effect the Lewis acid-mediated hydrodefluorination (HDF) of fluoroalkanes with silanes, despite the phosphorus center being …
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