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Showing 1 to 3 of 3 for “"disulfide stress"”.

  1. INVESTIGATION OF UNIQUE COENZYME A BIOSYNTHETIC AND REDOX FUNCTIONS IN Bacillus anthracis

    … target. The intracellular cellular thiol-disulfide redox status of B. anthracis is maintained by coenzyme A-disulfide reductase (BACoADR), which catalyzes the NAD(P)H-dependent reduction of coenzyme A-disulfide (CoAD) to 2 CoASH. B. anthracis also contains an additional CoADR isoform, …

    wfu Repository record for INVESTIGATION OF UNIQUE COENZYME A BIOSYNTHETIC AND REDOX FUNCTIONS IN Bacillus anthracis (opens in a new tab)

  2. Investigating Therapeutic Strategies to Target Metabolic Vulnerabilities of Nsclc Tumors With Mutant Keap1 Gene

    … of cellular anti-oxidant response. Under unstressed basal conditions, NRF2 interacts with KEAP1, a tumor suppressor gene and a substrate adaptor protein of the Cullin3-dependent ubiquitin ligase complex, which targets it for polyubiquitination and proteasomal degradation. KEAP1-NRF2 pathway …

    uthsc Repository record for Investigating Therapeutic Strategies to Target Metabolic Vulnerabilities of Nsclc Tumors With Mutant Keap1 Gene (opens in a new tab)