Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"distal nephron"”.
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Regulation of Functional Expression of Mechanosensitive Trpv4 Channel In The Distal Nephron By Dietary Potassium and Sodium Intake
… TRPV4 channel is predominantly expressed in the distal nephron (DN) and its activity is essential for [Ca<sup>2+</sup>]<sub>i</sub> elevations in response to increased tubular flow. Here, I probed the physiological mechanisms controlling TRPV4 function and expression in the DN. I found that renal …
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Studies of the excretion of aluminium by the kidney and the toxic effects of the element on DNA
… pig kidney. Al was found to be excreted in the distal nephron of the pig kidney. Secondly, the toxic effects of Al in vitro on the DNA of pig kidney cell line LLC-PKl were investigated, in an attempt to elucidate some of the mechanisms of toxic action. DNA synthesis was measured using ³H-TdR …
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The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells
The collecting duct of the distal nephron marks the final location where adjustments to Na+ excretion can be made, therefore determining the final concentration of Na+ conserved in the extracellular fluid which plays a role in governing overall blood volume and pressure. This transport of Na+ is …
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Regulation of sodium channel densities in A6 renal epithelial cells by hormonally-dependent mechanisms
… epithelia, such as cells of the renal distal nephron, constitute the rate limiting step in the transcellular transport of sodium. The regulation of sodium ion reabsorption in the kidney, which is essential for salt and water homeostasis, is therefore governed by the cellular control of …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
… that only the abundance of transporters in the distal nephron (NCC, ENaC, AQP2) was similar to pregnancy, however differences were seen in pre-macula densa transporters (NHE3, NKCC2). The similar changes observed in the distal convoluted tubule and renal collecting duct promote Na and water …