Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"distal lung"”.
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Development of an in vitro human lung organoid system to study alveolar type 2 stem cell maintenance and dysfunction during disease
The human adult distal lung parenchyma is maintained by alveolar type 2 (hAT2) cells that have the ability to self-renew and differentiate into alveolar type 1 (hAT1) cells, a critical cell type involved in gas-exchange. Cellular damage within the alveoli can lead to severe lung dysfunction, and …
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Fibroblasts as matrix modulating cells in asthma and COPD
Chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are two lung diseases that are continuously increasing worldwide. Despite extensively research to find curative treatment, no so such therapy exists today. New hypothesis suggests that an aberrant chronic wound …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
… to estimate regional dosimetry under direct-to-lung (DTL) and mouth-to-lung (MTL) vaping regimens. DTL produced higher overall deposition, particularly in distal lung regions, while MTL led to greater deposition in the upper airways. These differences reflected DTL’s higher flow rates and larger …
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A novel role for Sprouty2 in co-ordinating airway and vascular growth of the fetal lung.
… branching and vascular growth in the developing lung are intimately co-ordinated processes which involve cross-talk between the primary inducer of airway tube elongation, Fibroblast Growth Factor 10 (FGF10) and the pro-vasculogenic transcription factor, Hypoxia Inducible Factor 1a (HIF-1a). The …
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The emerging role of mesenchymal stromal cells among therapeutic options for chronic obstructive pulmonary disease
… Noxious particle or gas exposure to cells in the lungs leads to a chronic and sometimes irreversible state of airway inflammation, resulting in airflow limitation, hyper production of mucous, and destruction of distal lung tissue including gas exchange surfaces. COPD patients often develop dyspnea …
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a chronic lung disorder associated with extremely premature birth, resulting from arrested development of the microvasculature and consequently disrupted alveologenesis. Premature infants are dependent on respiratory support, including oxygen supplementation and …
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Maturation of pluripotent stem cell-derived alveolar type II cells at air-liquid interface and response to environmental stimuli
… cells (AT2s) are facultative progenitors of the distal lung epithelium and secrete surfactant, a protein-lipid mixture that lowers alveolar surface tension and prevents alveolar collapse during expiration. AT2s exist at a physiological interface between inhaled air and pulmonary vasculature, and …
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Effects of hypercapnic acidosis on the primary cells relevant to acute respiratory distress syndrome pathophysiology and the therapeutic potential of Mesenchymal Stem Cells
… the therapeutic effects of MSCs on repair of the distal lung epithelium, revealing a novel mechanism for the effects of MSCs in ARDS.<br/>
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Oxidative stress and metal homeostasis at the air-lung interface in Chronic Obstructive Pulmonary Disease
… which triggers abnormal inflammation in the lung. Consistent with this increased inflammatory burden, oxidative stress has been demonstrated in COPD patients, largely through determination of antioxidant and oxidative damage marker concentrations in exhaled breath condensate and induced …
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Stem and Progenitor Cells in Homeostatic Maintenance and Perturbation of the Pulmonary Epithelium
… a normal pseudostratified airway epithelium to lung squamous cell carcinoma in situ are well documented. However, the contribution of mutated tissue stem or progenitor cells to this process are poorly understood at the level of clonal resolution. Secretory cells are known progenitor cells of the …