Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"distal colon"”.
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
… (scFOS) or 10% inulin and fed for 28 d. Distal ileum, cecum, and colon samples were collected for Ussing chamber, histomorphology, and qRT-PCR analyses. The effects of treatment were tested using the Mixed Models procedure of SAS. Among treatments, mice fed scFOS and inulin had greater …
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Expression and Function of Galanin in Colonic Sensory Neurones
… the GI tract, such as pain. In particular, the distal colon is a key source of visceral pain in both inflammatory bowel disease (e.g. ulcerative colitis and Crohn’s disease) and irritable bowel syndrome. In both conditions, pain relief is complicated by the GI side effects of commonly prescribed …
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Notch activation and clone fate in intestinal homeostasis and inflammation
… the small intestinal epithelium rather than the colon. In this study I aim to determine the effect of Notch signals on the cell cycle and ISC clone dynamics in the colonic epithelium. Using double nucleotide labelling and pulse-chase lineage tracing experiments along with immunofluorescence and …
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Effects of potato fiber and soluble corn fiber on the fecal microbiome of dogs with implications to inflammation
… by showing suppression (P < 0.05) of distal colon gene expression of inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-17A). What was particularly interesting were the changes in distal colon gene expression of CXCL1, which is a neutrophil chemoattractant. Mice provided …
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Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis
… EHEC) infections in mice. C. rodentium causes colonic hyperplasia and a variable degree of colitis and mortality in the majority of inbred and outbred lines of mice. Differences in C. rodentium-induced disease are determined by the genetic background of the host. Here, C. rodentium infection in …
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Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis
… UC presenting with inflammation limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha …
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Effects of psyllium in milk replacers for neonatal dairy calves
… viscosity was increased in the abomasal and colon digesta for the PSY treatment. In addition, DM content of digesta from the proximal colon, distal colon, and feces was decreased for the PSY treatment. Apparent digestibility of DM was greater for the CON treatment. The predominant effect of …
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Diet and exercise modulate the gut microbiome with implications for health and disease
… on host gene expression in the brain and colon. To do this, we analyzed tissues collected from a previous experiment in which we transplanted cecal contents from exercised or sedentary mice into two groups of germ-free mice. After five weeks of colonization, recipient mice were euthanized …
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Dietary protein ameliorates goblet cell loss and modifies inflammatory responses in the colon of hnRNPI knockout mouse
… were assessed by body weight, growth rate, colon parameters and histology analysis. Goblet cells were quantified by staining. Relative mRNA levels of inflammation- and goblet cell-associated genes were examined using quantitative real-time PCR. CD4+ T cell subpopulations in the distal colon …
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Prevalence and control of Clostridium difficile in patients with cystic fibrosis
… C. difficile in an ex-vivo model of the human distal colon. Despite reducing viable C. difficile by 1.75 logs over 24 hours, this bacteriophage was not suitable due to its lysogenic nature. Following treatment, all surviving C. difficile were immune to reinfection due to prophage integration. …
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Harnessing the bacteriocin-producing capacity of the gut with a view to controlling microorganisms that have been associated with obesity and related metabolic disorders
… populations using an ex vivo model of the distal colon. Although both strains altered microbial populations over the 24 hr fermentation period, a number of beneficial changes were attributed to DPC6988 only. Finally, the ability of DPC6988 to alter the gut microbiota and mitigate the …
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Cystic fibrosis and the gut microbiota
… of fresh faecal samples on one day to perform distal colon models of the CF gut we investigated the viability of freezing faecal samples prior to preparation of faecal inoculum. Overall the results presented in this thesis demonstrate the differences in the gut microbiota between CF persons and …
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Changes in the Expression of Thin Filament-Associated Proteins in Colonic Smooth Muscle from Mice During Inflammation
… MLC20 phosphorylation and contraction in colonic smooth muscle. Although, thin filament- associated proteins such as calponin, caldesmon, tropomyosin and smoothelin do not directly participate in contraction, they regulate acto-myosin interaction and thus, muscle contraction. Calponin, …
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Genetic Control Of Enteric Nervous System Development And Subtype Specification
… including submucosal plexus hypoganglionosis, distal colon hypoganglionosis, and impaired colon motility (Chapter 5). These studies enhance our understanding of the genetic causes of motility disorders and provide a wealth of data on subtype-specific gene expression in the ENS.
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Activation of proestrogens from hops by human intestinal bacteria: conversion of isoxanthohumol into the potent phytoestrogen 8-prenylnaringenin
… showed up to 80% IX conversion, mainly in the distal colon. Experiments with 51 fecal samples indicated significant interindividual variations, with high, moderate and low 8-PN producers. An experiment with germ-free and human microbiota associated rats and a human intervention trial confirmed …
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Influence of oligosaccharides and fish oil on gastrointestinal tract characteristics and metabolic profiles of humans, pigs, and rats
… the UCNF. Similar effects were noted in RBC and colonic and cecal mucosa. Proinflammatory prostaglandins were reduced due to the UCNF compared to the control, while leukotrienes were unaffected. Serum metabolites, hematology, urinalysis, bifidobacteria, and histology were unaffected by treatment. …
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Renin-angiotensin system in intestinal inflammation : experimental studies with therapeutic interventions
… specific induction of ACE ectodomain shedding in distal colon, the most affected region in DSS-induced colitis, and in proximal colon following a high DSS dose. ACE shedding could be downregulated by cryopreserved MSCs and an ACE-inhibiting tripeptide Ile-Pro-Pro treatment in vivo. These data …
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Characterisation of the role of Fas in intestinal inflammation and cancer
… expression of Fas and FasL was reduced in the distal colon tissue from germ-free (GF), TLR4 and TLR5 knock-out (KO) mice but was unchanged in TLR2KO tissue, suggesting that intestinal cancer cells display a degree of specificity in their ability to upregulate Fas and FasL expression in response …
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Host-Microbiota Interactions
… microbiota produces butyrate, which provides the colon’s epithelial cells with about 70% of their energy needs. The typically fast proliferation of tumor cells in CRC patients drastically alters the tumor’s nutrient microenvironment. Those alterations correspond to changes in the microbiota …
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Data Management tools For Metagenomic Datasets, A Case Study: Characterization and Dysbiosis of Gut Microbiota In Apcmin/+ Mice With and Without Colon Tumors
… and expensive detection procedures such as CT-colonoscopy and endoscopy make early screening inconvenient and difficult. Therefore, alternate diagnostic strategies such as finding possible biomarkers can help discover colon cancer at an early stage. </p> <p>So far, only 1-15% of microbes have …
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