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Showing 1 to 20 of 153 for “"dissolution rate"”.
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The dissolution rate of chrysotile
… and silicon. As a result they are quite undersaturated with respect to chrysotile and chrysotile will dissolve. Its persistence in lung tissue is simply a result of its dissolution kinetics. The purpose of this study was to estimate the lifetime of a respirable size fiber of chrysotile in lung …
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Apparent dissolution rate enhancement of poorly-water soluble drugs by adsorption technique
… Most of the NCE’s are lipophilic and have dissolution rate issues. Low dissolution rate of the drugs result in poor bioavailability. To overcome poor bioavailability, an adsorption technique is developed to enhance the apparent dissolution rate of poorly-water soluble drugs. In this study, …
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The effect of Carbopol 934 rheological properties on the dissolution rate of sulphadamidine crystals.
… mechanisms by which a binding agent reduces the dissolution rate of a drug. For this the polymer Carbopol 934 (BF Goodrich) and a model drug, sulphadimidine, were chosen because their physicochemical properties could be changed by experimental variables, namely pH, temperature and salt …
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Influence of Water Chemistry Parameters on the Dissolution Rate of the Lead (II) Carbonate Hydrocerussite
This work has focused on the kinetic dissolution of the lead (II) carbonate hydrocerussite (Pb3(CO3)2(OH)2) under four pH conditions (7.5, 8, 9, 10), three dissolved inorganic concentrations (DIC; 10, 20, 50 mg C/L), and three initial hydrocerussite concentrations (10, 20, 50 mg/L) in batch …
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Field Test of a Calcite Dissolution Rate Law: Fort’s Funnel Cave, Mammoth Cave National Park
<p>The laboratory-derived calcite dissolution rate law of Plummer et al. (1978) is the most widely used and mechanistically detailed expression currently available for predicting dissolution rates as a function of water chemistry. Such rate expressions are of great use in understanding timescales …
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Controls on Dissolution Rate Variation at a Pair of Underflow-Overflow Springs at The Savoy Experimental Watershed
<p>Physical dissolution experiments and numerical modeling have been used in the past to study limestone dissolution rates. Numerical models have typically used constant dissolution rates, whereas rates in nature vary in time. Limestone tablets allow natural estimation of rates over month time …
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A study of the mechanisms of milling-induced enhancement of solubility and dissolution rate of poorly soluble drugs
… have potential to enhance the solubility and/or dissolution rate of poorly soluble drugs. There are broadly two aims for this project. The first was to develop an understanding of how individual and combination of techniques may be used to explore the impact of milling on particle characteristics …
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Surface Reactivity and Dissolution Rate of Galena: Potential Impact of CO2 Leakage from Geological Carbon Sequestration on Groundwater Quality
Geological carbon sequestration is one promising solution to mitigating CO2 emissions and curtailing global
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Effects of API particle size on the dissolution rate in molten polymer excipient matrices during hot melt extrusion, conducted in a co-rotating twin-screw extruder
… Ingredient (API) particle size on the dissolution rate in the polymer excipient during hot melt extrusion is investigated using a co-rotating twin-screw extruder with three different screw configurations. Acetaminophen (APAP) and amphiphilic polyvinyl caprolactam-polyvinyl …
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The hydrated lime dissolution kinetics in acid mine drainage neutralization
Hydrated lime, Ca(OH)₂, has been rediscovered as an environmentally sustainable product, which could be of help in the remediation of acid mine drainage (AMD), especially in the AMD neutralization process. This is due to its ease of acquisition, affordable price and unique versatile properties such …
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DEVELOPMENT OF A NEW CONTROLLED RELEASE DOSAGE FORM OF ACETYLSALICYLIC ACID
… Sustained Release Aspirin, {Bayer}), in vitro, (dissolution rate testing). Differences in dissolution rate constants and dissolution half-lives (Two) were analyzed by one-way analysis of variance for the effect of formulation (six groups of ASA dosage forms were tested) and the effect of the …
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Production of stable bcs class ii drug suspensions by melt emulsification and subsequent incorporation into polymer strip films
One of the ways to improve the dissolution rate of poorly water-soluble drugs is to produce fine drug particles with increased surface area. This increase will lead to bioavailability enhancement. However, smaller drug particles are thermodynamically unstable and tend to aggregate or grow. …
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… drying on apparent solubility and intrinsic dissolution rate was determined. All the spray dried composites exhibited higher apparent solubility and intrinsic dissolution rate when compared to the pure drugs and their physical mixtures. The stability of the spray dried composites upon storage …
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Development and characterization of a novel drug dissolution test method using a quartz crystal microbalance
<p>Current dissolution apparatuses require several hundred milligrams of sample per trial, measure dissolution rate indirectly via concentration sampling, and cannot maintain sink conditions throughout the duration of a test. This work describes a novel dissolution testing methodology developed …
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Silicate Mineral Dissolution and Associated Carbonate Precipitation at Conditions Relevant to Geologic Carbon Sequestration
… mineral, was studied with respect to its dissolution rates and its release of dissolved magnesium for subsequent precipitation of Mg-carbonate minerals. This study was conducted at conditions relative to GCS. Under different geological conditions, the thermodynamics and kinetics of both …
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Silica dissolution at low pH in the presence and absence of fluoride
… are present in nearly every natural setting. The dissolution of silica and glass by HF plays a very important role in technology and is widely used for the etching of silica and silicate glasses in the glass industry, in the flint industry, in surface micromachining, in etching of glass fibers for …
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Particle engineering via surface modification during micronization for pharmaceutical applications
Improving the dissolution rate of Biopharmaceutics Classification System (BCS) class II drugs is an important research area. Micronization which can increase the specific surface area is a promising method to improve the dissolution rate. Micronization alone, however, can lead to downstream …
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Understanding the Solid State, Solubility and Dissolution Behavior of Cefuroxime Axetil Diastereomers in Interactive Mixture Formulations
… major objective of this project was to study the dissolution behavior of interactive mixtures containing CFA. Mechanically stable interactive mixtures were prepared utilizing the amorphous and crystalline forms of the drug with hydrophilic carrier particles. The dissolution rate of CFA was …
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