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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 38 for “"disordered protein"”.

  1. Intrinsically Disordered Protein Polymer Libraries as Tools to Understand Protein Hydrophobicity

    Tang, Nicholas Chen2019

    <p>Intrinsically disordered protein polymers (IDPPs) are repetitive biopolymers that, when enriched with prolines, glycines, and aliphatic amino acids, have observable lower critical solution temperature (LCST) phase transition behavior at physiologically relevant temperature and concentration …

    duke Repository record

  2. Mechanisms of Adsorption and Surface-Mediated Aggregation of Intrinsically Disordered Protein Tau at Model Surfaces

    Mucci, Nicolas J.University of Kansas2015

    … adsorption and aggregation of an intrinsically disordered soluble protein, tau, into insoluble filaments is a defining hallmark of many neurodegenerative diseases, commonly referred to as tauopathies. In its native state, the protein tau’s function is to promote the assembly, and aid in the …

    ku Repository record

  3. Elucidating the Structural and Dynamical Properties of the Intrinsically Disordered Protein Nrf2 Using Molecular Dynamics Simulations

    Chang, Megan NicoleThe University of Western Ontario2021

    … factor erythroid 2-related factor 2 (Nrf2) protein is a critical transcription factor for activating the antioxidant response pathway, a primary defense mechanism against disproportionate levels of oxidants in the cell, via the upregulation of cytoprotective genes. Notably, aberrant …

    uwo Repository record

  4. Disordered Protein Aggregates Are Linked to Changes in the Histone Post-Translational Modification Landscape in Disease and Non-Disease Models

    Cobos, SamanthaThe Graduate School and University Center of The City University of New York2023

    <p>Proper protein folding is a delicate balance that is crucial for normal biological function. In mammals, protein misfolding and aggregation leads to loss of function of the original protein while in many cases being associated with neurodegenerative diseases, eventually leading to death of the …

    cuny-grad Repository record

  5. Probing Order within Intrinsically Disordered Proteins

    Crabtree, Michael DavidUniversity of Cambridge2017

    Decades have passed since the realisation that a protein’s amino acid sequence can contain all the information required to form a complex three-dimensional fold. Until recently, these encoded structures were thought to be crucial determinants of protein function. Much effort was directed to fully …

    cambridge Repository record

  6. Small Molecule Binding to Disordered Proteins

    Heller, Gabriella Tamar HarrisUniversity of Cambridge2020

    The human proteome includes many proteins that are entirely disordered or contain long disordered regions. Although these proteins are linked with many diseases, there are currently no clinically-approved drugs that have been shown to target these proteins in their monomeric forms. In fact, …

    cambridge Repository record

  7. Programmable Assembly of Elastin-like Polypeptides Within Droplet Microenvironments

    Simon, Joseph2017

    <p>Disordered proteins lack a defined secondary and higher order structure, possess a large number of biological functions, and are prevalent throughout nature. One important property of certain disordered proteins in biology is an ability to phase separate within the interior of a cell and form …

    duke Repository record

  8. Direct Computations of Spatially Resolved Viscoelastic Moduli of Biomolecular Condensates

    Gu, Liwen2025

    … simulations of A1-LCD, a type of intrinsically disordered protein, we examine how network topology influences storage modulus, loss modulus, crossover frequency, and relaxation time spectra. Our results reveal a strong correlation between topological features and mechanical response, with the …

    wustl Repository record

  9. Insights into p53-Dependent Apoptotic Signaling and Cell Fate vis-a-vis Functional Cooperation among BCL-xL, Cytoplasmic p53, and PUMA

    Fisher, John C.2016

    … upregulated modulator of apoptosis), a BH3‑only protein that binds and inhibits the anti‑apoptotic BCL‑2 repertoire, including BCL‑xL. Structural investigations of PUMA and the BCL‑xL×PUMA BH3 domain complex by X‑ray crystallography and nuclear magnetic resonance (NMR) spectroscopy reveal a …

    tenn-hsc Repository record

  10. Modeling intrinsically disordered proteins ; a comprehensive study of [alpha]-synuclein

    Ullman, OrlyMassachusetts Institute of Technology2015

    … to study because it is an Intrinsically Disordered Protein (IDP); i.e., it lacks a well-defined structure in aqueous solution. Unlike folded proteins, IDPs typically interconvert between many different conformations during their biological lifetime. In this thesis we apply novel methods …

    mit Repository record

  11. The ultrastructural morphology of Eimeria tenella exhibits striking natural variation and undergoes significant changes during the first few hours of infection

    Burrell, Alana LucyOxford Brookes University2019

    … striking similarity with that of intrinsically disordered protein-containing droplet organelles; this comparison may help to direct future research into the character and function of these mysterious organelles. In an adjacent project, the organelle numbers and volumes for the E. tenella …

    oxford-brookes Repository record

  12. Developing Fast and Accurate Water Models for Atomistic Molecular Dynamics Simulations

    Xiong, YeyueVirginia Tech2021

    … including those of biomolecules such as proteins and DNA. Despite water's simple structure and countless studies carried out over the decades, the best water models are still far from perfect. Water models are normally divided into two types--explicit model and implicit model. Here my …

    vt Repository record

  13. Exploring induced secondary structure and unmethylated DNA binding domains of methyl CpG binding protein 2 (MeCP2)

    Hite, Kristopher Charles, author, Hansen, Jeffrey C., advisor, Woody, Robert W., committee member, Ross, Eric D., committee member, Mykles, Donald L., committee memberColorado State University. Libraries2011

    Our understanding of Methyl CpG binding protein 2 (MeCP2) structure and function has changed and expanded considerably over the last two decades. Mutations along the entirety of the human MeCP2 gene product lead to a disease state - Rett syndrome. The clinical connection of this protein has …

    colostate Repository record

  14. Molecular Mechanisms of DNA Protection by Tardigrade Damage Suppressor Protein (Dsup): Structural Adaptation and Functional Interactions

    Tran, Huy2028

    … largely attributed to the DNA damage suppressor protein (Dsup). This study investigates the molecular mechanisms underlying Dsup’s DNA-protective function, focusing on its structural adaptability and interaction with nucleic acids. </p> <p>Using a combination of bioinformatics, biophysical …

    chapman Repository record

  15. Structural and functional studies of intrinsically disordered fibronectin-binding proteins

    Norris, Nicole CatherineUniversity of York2009

    Bacterial fibronectin-binding proteins (FnBPs) mediate adhesion of bacteria to host tissues through binding to the human protein fibronectin (Fn). FnBPs are predicted to contain a series of intrinsically disordered Fn-binding repeats (FnBRs), which undergo a disorder-to-order transition on binding …

    whiterose Repository record

  16. Yeast Ataxin-2 (Pbp1) Condensates Regulate TORC1 Activity and Autophagy in Response to Cellular Redox State

    Yang, Yu-San2021

    … ataxin-2, also known as Pbp1 (Poly(A) binding protein-binding protein 1), is an intrinsically disordered protein that has earlier been implicated in stress granule formation, RNA biology, and neurodegenerative disease. However, the normal endogenous function of Pbp1 and ataxin-2 remains poorly …

    utswmed Repository record

  17. Phase Separation Mediated Compartmentalisation of Rotavirus Replication

    Acker, JuliaUniversity of Cambridge2025

    … particle assembly in rotaviruses. Intrinsically disordered proteins are key drivers of LLPS. In rotaviruses, the disordered protein NSP5 binds the RNA chaperone NSP2, viral RNAs and other viral proteins to form replication factories known as viroplasms. Early in infection, these conden- sates are …

    cambridge Repository record

  18. Structural Biology in Cellular Environments Using Sensitivity Enhanced NMR

    Ghosh, Rupam2025

    … state NMR to mammalian cells. DNP NMR can detect proteins at their physiological concentrations within cellular environment in tractable times. However, these experiments were limited to cellular lysates, which did not recapitulate the intracellular environment completely. Studying proteins within …

    utswmed Repository record

  19. Metabolism of Alpha-Synuclein by the 20S Proteasome

    Lewis, Karen Adell2010

    … by the intracellular aggregation of the neuronal protein alpha-synuclein (alphaSyn) that normally associates with synaptic vesicles. Within the aggregates, a fraction of alphaSyn is truncated at the C-termini, and these truncations are hypothesized to participate in disease pathogenesis. The …

    utswmed Repository record

  20. Understanding the membrane biophysics of alpha-Synuclein and its role in membrane curvature induction and structural remodeling

    Braun, Anthony Robert2014

    … (aSyn) is a 140 amino acid, intrinsically disordered protein that adopts an extended amphipathic alpha-helical structure upon binding the membrane. aSyn is the major proteinaceous component of insoluble fibrillar Lewy bodies, a hallmark of Parkinson's disease (PD). The precise roles of both …

    umn Repository record

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