Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 39 for “"disease modelling"”.
-
Examining the use of infectious disease modelling in outbreak response
Infectious disease modelling has been brought to the forefront of national public health decision making during the Covid-19 pandemic. While the field is highly technically developed, transformation of insights from infectious disease modelling into policy in a clear, timely, and relevant manner is …
-
Engineering Complex Kidney Structures for Disease Modelling, Drug Testing, and Studying Kidney Development
… in studying kidney development realistically, modelling diseases, and establishing therapeutic approaches. <br></br><br></br> To fill these gaps, we devised a 3D engineering system for rapid generation of custom-made geometrically predefined kidney units that more faithfully resemble their …
-
3D Cell Culture in Microgels: A Novel Screening Platform for Disease Modelling and Drug Testing
Cancer is the second leading cause of deaths in the world with colon cancer being one of the deadliest types of cancer. However, only 7% of new anti-cancer drugs make it through clinical trials and are brought to the market. This low success rate has been attributed to a lack of relevant cancer …
-
CRISPR AS A TOOL FOR TARGET DISCOVERY AND TECHNOLOGICAL INNOVATION: HIGH-THROUGHPUT CBE SCREENING TO EVALUATE M6A MODIFICATION PATHWAY IN CANCER PROLIFERATION AND DRUG RESISTANCE, AND INNOVATIVE PRIME EDITING STRATEGIES FOR DISEASE MODELLING AND THERAPY
… affect gene expression resulting in pathogenic disease phenotypes such as cancer proliferation. For instance, METTL3 promotes proliferation in colorectal cancer (CRC) and acute myeloid leukaemia (AML), and its downregulation by small molecule inhibitor affects proliferation in AML and is …
-
The role of transcription factor GATA6 in the development of the human pancreas
… mouse and human pancreatic development and diseases and highlight the fact that developmental studies of the pancreas in humans are imperative. The need to develop therapies for diabetes, a growing and one of the leading health problems worldwide, further compels more exploration in this …
-
Advanced Bioelectronic and Microphysiological Systems for Functional Studies of Stem Cell-Derived Neural Models
… the work addresses limitations in preclinical modelling by combining advanced microfabrication, flexible electronics, and human-relevant in vitro systems. The research spans: • 2D compartmentalised cultures for studying tauopathy in Alzheimer’s disease using microphysiological and bioelectronic …
-
Creating CRISPR-Cas9 genome edited iPSC lines to model a patient-specific mutation in mitochondrial disease
… in mt-aaRS cause tissue-specific mitochondrial diseases, especially affecting tissues with high energy expenditure like the nervous system, heart, and kidneys. However, disease mechanisms for the heterogeneous group of diseases have not yet been fully elucidated. Harnessing CRISPR-Cas9 genome …
-
Identification of the ERK5 Kinase as a Key Regulator of Embryonic Stem Cell Pluripotency
… and therefore in regenerative therapeutics and disease modelling.
-
From iPSCs to Engineered Heart and Liver Models: Modulating Genetic and Extracellular State for Maturity
… fully patient-specific tissues suitable for disease modeling. Together, these advancements establish improved hepatic and cardiac platforms that enhance maturation, scalability, and predictive function, providing valuable tools for disease modeling and preclinical drug testing and disease …
-
MODELLING RIBOFLAVIN TRANSPORTER DEFICIENCY (RTD) USING IPSC-DERIVED MODELS TO TEST GENE THERAPY EFFICACY
… is still unavailable. Herein, we developed three disease models through 2D motoneurons, spinal cord and retinal organoid differentiation of RTD patients-specific induced pluripotent (iPSC) line carrying several mutations in SLC52A2 gene. First, we tested gene replacement therapy on RTD type 2 …
-
Generation and characterisation of primary and pluripotent stem cell-derived human hepatoblast organoids
… could provide a new source of liver cells for disease modelling and regenerative medicine.
-
Generation of induced progenitor-like (iPL) cells using interrupted reprogramming
… cell replacement therapy, biohybrid devices, disease modelling, and drug screening for human diseases.
-
MATHEMATICAL MODELLING FOR REAL-TIME AND PROSPECTIVE ASSESSMENT OF INFECTIOUS DISEASES
Infectious diseases are a major threat to population health and often require decisions to be made under uncertainty about current and future dynamics. Mathematical models provide a way to combine mechanistic knowledge with surveillance data and to evaluate alternative intervention strategies. …
-
Modelling Huntington’s Disease Using Direct Cell Reprogramming
Huntington’s disease (HD) is a neurodegenerative disorder characterised by the progressive decline of motor, cognitive, and psychiatric functions. HD results from an autosomal dominant mutation that causes a trinucleotide CAG repeat expansion and the production of a mutant Huntingtin protein …
-
Investigating the role of cell cycle regulators in mesoderm specification
… of mesoderm is interesting for a diversity of diseases and clinical application. In vivo study of human development beyond gastrulation is technically challenging and the mechanisms controlling mesoderm specification are difficult to study since the maximum number of days allowed to grow human …
-
The Role of Cervical Reserve Cells in Epithelial Regeneration and Homeostasis in the Murine and Human Cervix
… HR-HPV infections. In recent years, advances in modelling the human tissue in 3D manner using organoids have been made (3). In this thesis, a 3D murine cervical organoid model was established. Two distinct microenvironments for the growth of endocervix and ectocervix is defined. Generated …
-
Elucidating the underlying mechanisms of diabetic endotheliopathy using patient specific induced pluripotent stem cells
… applications including cell-based therapy, disease modelling and drug screening; they can be used in mechanistic studies towards the development of novel therapies and in the discovery of new biomarkers to be applied in regenerative medicine and treatment of diabetic vasculopathy. Here we …
-
Instructing naïve pluripotency ; JAK/STAT3 and Nanog in reprogramming
… of induced pluripotent cells in in vitro disease modelling, drug screening and regenerative medicine. The pluripotency associated transcription factor Nanog has been subject to a lot of controversy. Initially thought to form an essential trinity with Oct4 and Sox2 to maintain embryonic …
-
Modelling Embryonic Haematopoiesis Using In Vitro State-of-art Gastruloid Culture
… protocol could be applied as a drug screening or disease modelling tool, such as an infant leukaemia disease model.
-
INDUCED PLURIPOTENT STEM CELL DERIVED LIVER MODEL FOR THE STUDY OF PNPLA3-ASSOCIATED NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in the developed world, afflicting approximately one in four adults globally. NAFLD is defined by the accumulation of fat within the liver which ranges in severity from simple steatosis to non-alcoholic …
Page 1 of 2