Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"disease mechanisms"”.
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Omics analysis in understanding disease mechanisms
… phases, understanding the role of targets in disease mechanisms is crucial for accelerating drug development and identifying beneficiary patient cohorts. Although Machine Learning-based approaches unveil cryptic patterns from biological data, their application in smaller scale research is …
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Towards systems pharmacology models of druggable targets and disease mechanisms
… comprehensively model the fundamental biology of disease mechanisms in a quantit- ative manner. They are computational models, designed and hailed as a strategy for making well-informed and cost effective decisions on drug viability and target druggability and therefore attempt to reduce this …
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RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS
… OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS By Frank Sungping Chen Advisor: Ching-Kang Jason Chen, Ph.D. Retinal photoreceptors provide the first gateway in which light information from the environment is transformed into neuronal signals. The cone and rod photoreceptors …
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Disease mechanisms and markers of progression in cerebral small vessel disease
Introduction <br>Cerebral small vessel disease (SVD) is a common disease process accounting for a quarter of all ischaemic strokes, around 80% of haemorrhagic strokes, and is the major contributor to vascular cognitive impairment and dementia. Despite it being a major public health burden, …
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Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms.
… an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic factors (C3 …
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Human Stem Cells for Modeling Amyotrophic Lateral Sclerosis Disease Mechanisms and Modifiers
… sclerosis (ALS) is a fatal neurodegenerative disease of the motor system. Although ALS has been extensively studied in post-mortem patient samples and animal models, there are currently no very effective treatments and there is no cure. One reason for the lack of treatment options in ALS may …
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Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms
… organogenesis, health, and others genetic diseases. Primary cilium functions as a mechano-sensor and chemo-sensor. Defect in primary cilia causes the progression of polycystic kidney disease (PKD) which further leads to the inflammatory responses. We, therefore, investigated the role of …
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Restoring the Balance: Unraveling disease mechanisms and exploring shared therapies for lysine metabolism disorders using human neural models
Contains fulltext : 329214.pdf (Publisher’s version ) (Closed access)
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Computational methods for personalized cancer genomics
… molecular profile can be used to 1) identify the disease mechanisms and underlying cause of a single patient’s cancer, 2) assign patients into treatment groups based on the molecular prognosis, and 3) recommend potential treatments for individual patients based on the patient’s molecular signature …
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Correlation-based Linking of Epigenomic Regions to Target Genes in Bulk and Single Cell Epigenomic Data
… for peak-gene linking via correlation-based mechanisms. This approach provides a robust framework for bias correction and noise reduction at single-cell resolution. Our research introduces a novel algorithm that employs peak-gene linking to integrate epigenomic data, thereby translating it …
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The effect of Alzheimer's disease on cortical microcircuits
… and accelerate new treatments for Alzheimer’s disease. An improved mechanistic understanding of the human disease will facilitate new treatments. Human pathophysiological biomarkers sensitive to treatment and disease mechanisms will help accelerate such new treatments. To this end, …
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Mapping the Spatial Transcriptome Across Whole Organisms
… for insights into neural circuit coordination, disease mechanisms, and developmental biology.
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Factors That Mediate Expression Of Unique Ggggcc Repeat Expansions In C9orf72-Associated Als/ftd.
… non-AUG (RAN-) translation products occurs in diseased tissue. Herein, we developed two Drosophila models that overexpressed G4C2-repeats. Expression of >30 repeats causes degenerative effects supporting gain-of-function mechanisms are contributing to disease. To define disease mechanisms, we …
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Learning Statistical and Geometric Models from Microarray Gene Expression Data
… meaningful and specific information about disease mechanisms from microarray gene expression data. To provide a high-level overview of gene expression data for easy and insightful understanding of data structure, we propose a novel statistical data clustering and visualization algorithm …
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Parkinson's Disease-Associated Protein VPS13C Regulates Phospho-Rab10-Mediated Lysosomal Function in Human iPSC-Derived Dopaminergic Neurons
Neurodegenerative diseases are progressive disorders with age as the greatest risk factor. Parkinson’s disease (PD) is the most common movement disorder and the second most common neurodegenerative disease after Alzheimer’s disease. A stark increase in the incidence of neurodegenerative diseases is …
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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
<p>Mouse models of Alzheimer’s disease (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and …
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Genetic determinants underlying rare diseases identified using next-generation sequencing technologies
… starting point in understanding the molecular mechanisms underlying these diseases. The advent of next-generation sequencing has accelerated discovery of disease-causing genetic variants and is showing numerous benefits for research and medicine. I describe the application of next-generation …
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Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension
… predictors of prognosis in many cardiovascular disease states. Despite the significance of RV function to survival, there are no therapies that directly nor selectively improve RV function. As well, the basis for RV failure is poorly understood. This is particularly relevant for patients with …
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Representation Learning Associates Patients’ Risks for Metabolic Diseases with Features of Their Lipocytes
… an individual’s risk of developing a certain disease, suggesting that differences between cells of individuals with high versus low PRS could give us insight into the cellular disease mechanisms. To study metabolic diseases, we analyze the distribution of cell states of lipocytes of …
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