Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"disease heterogeneity"”.
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Profiling neuroinflammation in amyotrophic lateral sclerosis
… lateral sclerosis (ALS) is a neurodegenerative disease primarily characterised by progressive loss of motor neurons. ALS is highly heterogeneous and exists on a clinical and pathogenetic spectrum with frontotemporal dementia (FTD); those anywhere on this spectrum are said to have …
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ASCL2 Positive Tumor Cells Modulate the Response of Metastatic Colorectal Cancer to MAPK-Targeting Therapy
… a quarter of patients presenting with metastatic disease at the time of their diagnosis. Therapeutic management of metastatic CRC continues to be a major challenge due to therapy resistance and disease heterogeneity. Due to its central role in tumorigenesis, CRC is commonly treated with MAPK …
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Statistical co-analysis of high-dimensional association studies
… results using summary statistics from a related disease. I extended an existing method to enable a shared control design, increasing power and applicability, and developed an approximate bound on false-discovery rate (FDR) for the procedure. Using the new method I identified several new …
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INTEGRATION OF REDOX-REGULATED SIGNALING AND METABOLISM IN HEAD AND NECK CANCER
… Squamous Cell Carcinoma (HNSCC) is a complex disease characterized by genetic and metabolic changes. Radiation therapy alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Resistance to radiation …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
Endometriosis (EM) is a chronic inflammatory disease whereby endometrial-like tissue grows ectopically, commonly presenting as dyspareunia, dysmenorrhea, and infertility. Due to invasive diagnosis, disease heterogeneity, and reproductive disorder stigmatization, patients often experience …
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GENOME-WIDE ASSOCIATION STUDY OF NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS IN MASLD: EVIDENCE FROM AN ITALIAN POPULATION
Metabolic Associated Steatotic Liver Disease (MASLD) is the most prevalent cause of chronic liver disease worldwide and a significant risk factor for cirrhosis and hepatocellular carcinoma (HCC). Despite its pathogenesis being determined by both environmental and genetic determinants, the genetic …
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Translating autoimmune genetic risk scores into improved prediction and classification of disease
… a lack of standardisation and understanding of disease heterogeneity. This thesis aims to address these issues by utilising genetic risk scores (GRS) to enhance type 1 diabetes prediction, differential diagnosis, and mechanistic classification. The lack of genetic risk score standardisation …
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Multimodal Prediction of Type 1 Diabetes
… established, the rate of progression to clinical disease varies markedly between individuals, creating both an opportunity and a challenge. Early identification can reduce diabetic ketoacidosis at diagnosis and enable the use of preventative therapies; however, disease heterogeneity limits the …
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Identification of Differentially Expressed Gene Modules in Heterogeneous Diseases
… associations between biomolecules and human diseases. This is a great advance for science and medicine since it helps to unravel the mechanisms of the diseases and gives clues for new treatment approaches. At the same time, a tremendous amount of raw experimental data and biomedical knowledge …
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Exploring the role of BCL11A in the oesophagus and mammary gland using in vivo lineage tracing and 3D organoid models.
… pursuit of effective cancer therapy, extensive disease heterogeneity remains one of the largest problems facing researchers. NGS sequencing has helped to identify specific markers of disease to deconvolute some of this heterogeneity, indeed it has also enabled the similarities of some epithelial …
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Interpreting transcriptional signatures and their relevance to disease biology, prognosis and treatment resistance in colorectal cancer
… malignancy with a number of different disease subtypes influenced by distinct biology. The clinical implications of this disease heterogeneity are likely to influence treatment strategies further in the future. Therefore, patient stratification is paramount in order to improve patient …
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The Biological Basis of Heterogeneity in Parkinson's Disease - Insights from an Innate Immune Perspective.
The biological basis of the clinical heterogeneity in Parkinson’s Disease (PD) is unclear. It is likely to involve complex interactions between genetic and environmental factors and between a range of pathological processes, including protein homeostasis and immune system function. Microglial …