Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"disease diagnostics"”.
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Noninvasive disease diagnostics using engineered synthetic urinary biomarkers
… is the first step in appropriately treating disease. Many diseases have confusing symptoms, nonspecific biomarkers, or require invasive biopsy; these factors and others contribute to the low rates of early diagnosis for noncommunicable diseases like cancer, clotting disorders, or fibrotic …
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Portable magnetic resonance sensors and methods for noninvasive disease diagnostics
Many diseases manifest as a shift in fluids between distinct tissue fluid compartments. For example, fluid depletion and fluid overload lead to a deficit or accumulation of fluids within the intramuscular interstitial space. A direct measurement of these fluid shifts could serve as a highly …
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Paper-based Molecular Technologies for Faster, More Accessible Infectious Disease Diagnostics
… accessible methods for diagnosing infectious diseases greatly hinders effective disease control in all parts of the world, but especially in resource-limited communities. Resource-limited areas frequently are the hardest hit by infectious diseases, but often cannot support the cost and …
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Volatile Organic Compound Detection And Disease Diagnostics Using Dna-Functionalized Carbon Nanotube Sensor Arrays
… organic compounds (VOCs) for early-stage disease diagnostics as well as various environmental monitoring applications. The aim of this thesis work was to address these challenges by developing an “electronic nose” (e-nose) platform based on chemical sensor arrays capable of detecting and …
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Improving Coronary Artery Disease Diagnostics with Massively Parallel, Personalized Flow Models and Immersive Treatment Planning.
<p>Cardiovascular diseases (CVDs) are the leading cause of death worldwide, accounting for more than 17 million deaths per year, a number that is expected to double by 2030. Atherosclerosis is the most common manifestation of CVDs, affecting large and medium-sized blood vessels such as coronary …
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Smartphone-based systems for mobile infectious disease detection and epidemiology
Infectious diseases remain a serious public health challenge worldwide and are the leading cause of death in many developing countries. The rapid detection of pathogens is vital for the control and prevention of the infectious diseases. New tools are needed to enable rapid detection, …
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Design methods for sensitive and comprehensive microbial surveillance
… medicine and public health, including infectious disease diagnostics, proactive pathogen detection and characterization, and microbiome studies. New genomic technologies are transforming microbial surveillance, but face challenges stemming from low concentrations in collected samples and …
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Aptamers that bind filovirus GP : a new frontier for detection and neutralization of Ebola and Marburg virus
… point of care devices for filovirus disease diagnostics. Finally, this work describes the use of a hybrid selection approach that combines two different selection platforms to generate aptamers that bind to EBOV surfaces.
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Carbon nanotube-based chemical sensing
… for applications in environmental monitoring, disease diagnostics, and food analysis: In Chapter 1, we introduce carbon nanotube-based sensing. We describe parameters that give rise to the sensing capabilities of CNT-based sensors and discuss important performance parameters of carbon nanotube …
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The Development of Assays for Detecting Proximal Phosphorylation and Covalent Modification of Proteins
… milestones in many pharmaceutical pipelines and disease diagnostics, and as such, must be designed and fine-tuned to produce meaningful, robust, and reproducible results. This thesis focuses on the design and development of unique bioassays for two important medicinal chemistry fields of …
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Graphene Inkjet Integrated Intelligent Sensors and Systems
… NH$_{3}$ and acetone for potential diagnosis of diseases. I also develop a machine-intelligent classification system based on inkjet-integrated $\alpha$-Fe$_{2}$O$_{3}$-rGO CMOS devices to selectively measure NO$_{2}$ air pollutants. The ink formulation and the theoretical model I develop …
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The development of new sensing methodologies for nucleic acids using arrays of silicon photonic microring resonators
… They are also implicated in a variety of diseases, such as cancer, neurodegenerative disorders, and diabetes. Despite their importance in a variety of cellular functions as well as their potential for disease diagnostics, miRNAs are incredibly difficult to detect. Their short length makes …
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Evaluation of the effects of gold nanoparticles (AuNPs) on protein folding in Escherichia coli
… industry. This has seen major improvements in disease diagnostics, therapeutics, imaging and treatment. All this is owed to the unique physicochemical properties possessed by the AuNPs. More studies continue to be carried out on AuNPs as the uses of these nanometer-sized particles are …
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FUNCTIONAL DIVERSITY OF FUNGI ASSOCIATED WITH DURUM WHEAT ROOTS IN DIFFERENT CROPPING SYSTEMS
… pea and chickpea. The classical method of root disease diagnostics in cereals is based on the examination of the subcrown internode. I evaluated the method by comparing the fungal communities associated with different subterranean organs of durum wheat. The fungal community of the subcrown …
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Laminar and Transitional Flow disturbances in Diseased and Stented Arteries
Cardiovascular diseases (CVD) are the number one causes of death in the world. According to the world Health Organization (WHO) 17.5 million people died from cardiovascular disease in 2005, representing 30 % of all global deaths . Of these deaths, 7.6 million were due to heart attacks and 5.7 …
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Detection of the Oak Wilt Pathogen in Sapwood of Northern Oak Species Using PCR Technology
… by Ceratocystis fagacearum, is important when disease control action is planned. When laboratory diagnosis is needed, standard isolation protocols that are used rely on high quality samples and require up to 14 days for incubation. New methods, involving the use of polymerase chain reaction …
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THE ATTACHMENT AND CHARACTERIZATION OF DNA PROBES ON GaAs-BASED SEMICONDUCTOR SURFACES
… numerous important technologies in the genomics, disease diagnostics and biosensors applications. The architecture and density of immobilized probe molecules depend on the type of the solid surface on which they are anchored. Even though many different types of surfaces have been studied as …
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Evanescent field enhanced fluorescence on a photonic crystal surface
… of surface-based fluorescent assays used in disease diagnostics and life science research. PCs can be engineered to support optical resonances at specific wavelengths at which strong electromagnetic fields are utilized to enhance the intensity of surface-bound fluorophore excitation. …
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Multiplexed, scalable, and functionality compatible platforms for 3D spatially resolved proteomic profiling
… and functional abnormality directly related to disease diagnostics and therapeutics. However, the widely used chemical fixation protocols don’t support functional detection of proteins, triggering the development of new tissue preservation technology for the unfulfilled aim of spatially resolved …
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Sensitive microarray-based biomarker detection using photonic crystal enhanced fluorescence and label-free imaging
… condensate samples holds great promise for disease diagnostics and therapy monitoring because of its non-invasive nature. The microarray format, for its high-throughput and low analyte consumption characteristics, is particularly well suited for such applications since testing with …
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