Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"disease association"”.
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Novel molecular markers of disease-association among strains of Streptococcus suis: a genomic approach
… suis (S. suis) isolates into two populations, i) disease-associated and ii) non-disease associated. S. suis is a Gram-positive coccus that is considered one of the most important zoonotic bacterial pathogens of swine responsible for significant economic losses to swine production worldwide. …
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BoLA Class II Genes: Polymorphism, Disease Association and Linkage Relationships With the Prolactin and Bola-A Genes
… of PL (P $<$ 0.05). There was a closer association of PL with DRB2 than with DQB or BoLA-A.
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Identifying drug-target and drug-disease associations using computational intelligence
… types of data in various public databases, drug-disease association identification and drug repositioning can be performed based on the interaction of drugs and biomolecules. Moreover, drug repositioning mainly focuses on the similarity of drugs and the similarity of agents interacting with …
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A novel computational method for predicting tissue-specific disease-associated signaling pathways in human utilizing Caenorhabditis elegans reference data.
… uncoordinated cellular behaviors will cause diseases. To study mechanism of signal transduction, diverse approaches have been applied, including traditional experimental and computational methods. Compared to traditional experimental approaches, computational methods are better in analyzing …
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Systematic Exploration of Associations Between Select Neural and Dermal Diseases in a Large Healthcare Database
… this research, we systematically examined associations among select neural and dermal conditions in an ultra-large healthcare database derived from an HIE, in which computational approaches with epidemiological measures were used. After a systematic cleaning, a binary logistic model-based …
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Methods for study and manipulation of protein self-assembly
… be observed in processes that are functional or disease-associated. The resulting fibrillar structures can be formed from a variety of different proteins, but all share a β-sheet rich architecture and a variety of remarkable optical and mechanical properties. Their disease association makes …
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Analysis of Coding Region SNPs and Its Propensity to Cause Disease
… in individuals are considered to be the cause of diseases, difference in response to treatment, susceptibility to diseases or may have no impact. Association studies aim at correlating an observed disease or a phenotype with these sequence variations. However very few of these SNPs are actually …
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Algorithms for discovering disease genes by integrating 'omics data
… characterization of complex human diseases remains as one of the biggest challenges in the post-genomic era. Information useful for mechanistic understanding of diseases comes from different types of “-omic” data, including genomic sequences, gene expression, and molecular …
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Developing a Valid Screening Tool for Assessing Nutritional Adequacy and Osteoporosis Risk Among Vegans in the United States
… with respect to nutrition adequacy and chronic disease concerns.</p> <p>The vegan diet engenders more concern than other common vegetarian lifestyles because it seeks to replace all nutrient-rich animal food products with only plant foods. Consequently, there are concerns of compromised protein, …
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Towards a Comprehensive Human Pathway Database For Systems Biology Applications
… new treatment and diagnostic solutions for human diseases. Pathway data are publicly available in many databases. Most of the databases however have only partial coverage of human biological pathways, especially for signal transduction and gene regulatory pathways. Comprehensive knowledge and a …
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The functional impact of copy number variation in the human genome
… genome and can play an important role in human disease. With array-based copy number detection and the current generation of sequencing technologies, our ability to discover genetic variants is running far ahead of our ability to interpret their functional impact. One approach to close this gap …
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Using DNA markers to trace pedigrees and population substructure and identify associations between major histocompatibility regions and disease resistance in rainbow trout (Oncorhynchus mykiss)
… the causative agent of bacterial coldwater disease (BCWD). The overall mortality rate was 70%, with large variation among families. Resistance to the disease was assessed by monitoring post-challenge days-to-death. Phenotypic variation and additive genetic variation were estimated using …
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Guillain Barre Syndrome (GBS) in Cape Town, South Africa: a descriptive outcomes cohort study
… with acute GBS, whether this reflects true disease association or merely high background disease prevalence cannot be confirmed by this study. AIDP is the most common phenotype unlike other LMIC regions such as Asia where AMAN predominates. In this cohort, 76% of participants showed good …
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Identifying protein complexes and disease genes from biomolecular networks
… (PPI) data, gene expression data, gene-disease association data, cellular pathway data, and so on, have been and will continue to be produced. Those data contain insightful information for understanding the mechanisms of biological systems and have been proved useful for developing new …
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Individuals with Parkinson's disease and their experiences with changes in communication and behavioral speech therapies
Background: Parkinson's disease (PD) is a major public health concern that affects the lives of nearly one million older adults in the United States. According to the World Health Organization, disability and deaths related to PD are rising more than any other neurological disease (2022). PD is …
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Lipoprotein(a) and the risk of vascular disease
… 40 years its relationship with coronary heart disease (CHD) has not been characterized in sufficient detail. Whether Lp(a) causes CHD is not clear. Furthermore, the role of apo(a) isoform variation and other sources of Lp(a) heterogeneity (e.g., level of oxidized phospholipids) in Lp(a)-disease …
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Cause and Impacts of the Early Season Collapse of Lilium grayi (Gray’s lily), on Roan Mountain, TN/NC
… and 0/30 asymptomatic plants. Strength of the association between pathogen and disease and the replication of disease symptoms in 4/4 healthy hosts showed that <em>P. inconspicua</em> was the causal agent of the disease referred to as lily leaf spot. Disease had a severe impact on the …
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Localization and Function Of RNA Interference in the Cerebral Cortex
… RNAs with many biological functions and disease associations. Association studies are rapidly linking miRNAs with cancers and neurological disorders. miRNAs have specific expression and function in specialized cell types, emphasizing the need to define cell-type-specific miRNA expression …
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Disease pathogenesis, treatment effectiveness, and co-morbid burden among adult patients with primary immune thrombocytopenia (ITP)
… immune thrombocytopenia (ITP) is an autoimmune disease involving autoantibody-mediated platelet destruction, suboptimal platelet production, and T-cell-mediated platelet lysis. These processes cause a decreased peripheral blood platelet count (< 150 x 109/L), resulting in an increased …