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Discodermolide synthesis : fragments A and BCD

Filla, Sandra Ann, 1966-Massachusetts Institute of Technology1994

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.

mit Repository record for Discodermolide synthesis : fragments A and BCD (opens in a new tab)

Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs

Qi, JunVirginia Tech2010

… all less active than paclitaxel and docetaxel. Discodermolide is a microtubule interactive agent, and has a similar mechanism of action to paclitaxel. Interestingly, discodermolide is active against paclitaxel-resistant cancer cells and can synergize with paclitaxel, which make it an attractive …

vt Repository record for Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs (opens in a new tab)

Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide

Wren, Stephen P.University of Cambridge1995

cambridge Repository record for Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide (opens in a new tab)

Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs

Yang, ChaoVirginia Tech2008

… evidence to support T-taxol conformation. (+) Discodermolide is a polyketide isolated from the Caribbean deep sea sponge <i>Discodermia dissoluta</i> in 1990. Similar to paclitaxel, discodermolide interacts with tubulin and stabilizes the microtubule <i>in vivo</i>. Studies aimed at …

vt Repository record for Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs (opens in a new tab)

The Development of Vinylheteroarene Linkers for Proteinogenic Cysteine Modification and Studies Towards Applying (+)-Discodermolide as a Novel Payload in Antibody-Drug Conjugates

Seki, HikaruUniversity of Cambridge2021

… Modification and Studies Towards Applying (+)-Discodermolide as a Novel Payload in Antibody-Drug Conjugates Hikaru Seki Antibody-drug conjugates (ADCs) are an emerging class of anticancer agents which combine the cell-targeting properties of a monoclonal antibody and the cytotoxicity of a small …

cambridge Repository record for The Development of Vinylheteroarene Linkers for Proteinogenic Cysteine Modification and Studies Towards Applying (+)-Discodermolide as a Novel Payload in Antibody-Drug Conjugates (opens in a new tab)

APPROACHES TO THE TOTAL SYNTHESIS OF DICTYOSTATIN AND SYNTHESIS OF EPI-DICTYOSTATINS

ZANATO, CHIARAUniversità degli Studi di Milano2010

… activity to that of the already very active discodermolide. Moreover, dictyostatin potently inhibits the binding of radiolabeled paclitaxel, discodermolide, and epothilone B to microtubules, and is also very active against paclitaxel-resistant cancer cell lines. Accordingly, (-)-dictyostatin …

milano Repository record for APPROACHES TO THE TOTAL SYNTHESIS OF DICTYOSTATIN AND SYNTHESIS OF EPI-DICTYOSTATINS (opens in a new tab)