Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"disc degeneration"”.
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MRI Assessments of Adjacent Disc Degeneration of Lumbar Fusion Group versus Discectomy Group
OBJECTIVE: Using MRI to assess intervertebral disc degeneration at adjacent levels in a group of patients who underwent spinal fusion compared to a group of patients who underwent discectomy. MATERIALS AND METHODS: Fifty-six patients who underwent spinal surgery for lumbar degenerative disease by …
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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
Intervertebral discs (IVDs) are unique musculoskeletal tissues within functional spinal unit organs comprising the spinal column that distribute loads and allow complex movements for vertebrates. IVD degeneration has been closely associated with manifestations of symptomatic IVD disease (IVDD). …
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Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration
Intervertebral discs (IVDs) are the cartilaginous structures in the spine that connect adjacent vertebrae, absorb shock from daily activities, and allow for articulation of the spine. Unfortunately, IVDs are prone to degeneration and have little to no capacity for self-repair. IVD degeneration is …
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MR assessment of the adjacent segment degeneration after discography
OBJECTIVE: It recently reported that intradiscal procedures during provocative discography damaged the punctured disc and accelerated disc degeneration in lumbar spine. We aimed to assess whether discography affect the acceleration of disc degeneration at the adjacent levels of lumbar fusion. …
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Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc
… gene expression in murine intervertebral disc (IVD) cells in response to mechanical load. We investigated the role of TRPV4 in age associated IVD degeneration and spine development using novel knockout mice. Spine samples were harvested from NotoCre;Trpv4fl/fl and WT mice at embryonic day …
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An Investigation Into The Mineral And Mechanical Properties Of The Canine Intervertebral Disc And Its Clinical Implications
Intervertebral disc disease is a very common problem in dogs. The disease causes pain and different degrees of neurological damage which can result in paralysis and leads to the death of many dogs annually. The disease is intimately associated with disc degeneration and calcification, but the …
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
Intervertebral disc degeneration has been identified as a main cause for low back pain, a large health problem in the Western world today with 60%-80% of people affected at some point during their lives. Current treatments alleviate the symptoms rather than repair the tissue, but tissue engineering …
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Ο ρόλος της αναστολής της ιντερλευκίνης 1β (IL-1β) στην εκφυλιστική νόσο του μεσοσπονδύλιου δίσκου
… του μεσοσπονδύλιου δίσκου (Intervertebral Disc Degeneration - IDD) είναι μια ευρέως διαδεδομένη παθογόνος κατάσταση που επηρεάζει το 12% με 35% του πληθυσμού παγκοσμίως. Πληθώρα ερευνών έχουν αναδείξει ότι ο εκφυλισμός του μεσοσπονδύλιου δίσκου είναι απόρροια διαφόρων παραγόντων όπως η …
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Characterisation of Ovine and Human Vertebral Endplates using X-ray Microtomography: the Effects of Degeneration on Structure.
… pathway and mechanical support to the disc, therefore making it prone to damage. However, the VEP is still poorly characterised. This thesis describes work undertaken to characterise the structure of normal and degenerative VEPs. Initially, ovine VEPs were used to investigate the effect …
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Development of an Injectable Methylcellulose Hydrogel System for Nucleus Pulposus Repair and Regeneration
… disability in the world and is often caused by degeneration or injury of the intervertebral disc (IVD). The IVD is a complex, fibrocartilaginous tissue that allows for the wide range of spinal mobility. Disc degeneration is a progressive condition believed to begin in the central, gelatinous …
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Numerical Techniques for the Noninvasive Assessment of Material Properties and Stresses in Soft Biomaterials
… as articular cartilage or the intervertebral disc. Such methods will allow for non-contact and patient-specific modeling in a manner not currently possible with traditional mechanical testing or finite element techniques. Therefore, the objective of this thesis was to develop computational …
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An in Vitro Microenvironment for Nucleus Pulposus Regeneration
Intervertebral disc degeneration begins early in life, increases with age, and can ultimately result in disc failure. At the center of the disc, the nucleus pulposus (NP) resides in a hypoxic environment where degeneration is thought to begin. Initially, nucleus pulposus cells (NPCs) display …
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In Vitro Assessment of Bone and Cartilage Stimulating Peptides
… commonly used surgeries to treat intervertebral disc degeneration (IDD) related low back pain. However, non-fusion still occurs in about 10-15% of the clinical cases. The global objective of this project is to develop a synthetic bone graft for the spinal fusion, combined with bone growth …
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Influence of mitochondrial and nuclear genomic dysfunction on lipid homeostasis in lipidemic diseases
Intervertebral disc degeneration (DDD) is a multifactorial, age-related disorder and a major contributor to chronic low back pain (LBP) and disability. Its pathogenesis involves extracellular matrix degradation and inflammation, augmented by mitochondrial dysfunction and dysregulated lipid …
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Polymer Composite Spinal Disc Implants
… similar to that of the natural intervertebral disc, as well as find preliminary results for vertebral endplate connection and nucleus pulposus internal pressure, for the correction of disc degeneration in the spine. The three-part composite samples needed to demonstrate good shock absorption …
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Extracellular Matrix Degradation and Mechanical Integrity of Degenerated Human Annulus Fibrosus from Surgical Specimens
Intervertebral disc (IVD) degeneration is a leading cause of low back pain, yet the mechanistic link between biochemical matrix degradation and functional mechanical failure of the annulus fibrosus (AF) remains poorly defined in human tissue. The interlamellar matrix (ILM), which binds adjacent …
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Mechanobiology of the nucleus pulposus: The effect of hydrostatic pressure and glucose deprivation on nucleus pulposus cell sub‐populations
The nucleus pulposus of the intervertebral disc contains two cell types: notochordal (NC) and chondrocyte‐like mature nucleus pulposus (MNP) cells; the ratio of which changes with species, age and health. Intervertebral disc (IVDs) that contain predominantly MNP cells are susceptible to …
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From Protein Structure to Clinical Strategy: An In silico Investigation of Mitochondrial DNA Mutations in Type 2 Diabetes and Degenerative Disc Disease for Targeted Nutritional Interventions
… Type 2 Diabetes Mellitus (T2DM) and Degenerative Disc Disease (DDD), represent major contributors to global morbidity and mortality, particularly within low- and middle-income countries where aging populations and chronic metabolic stress intersect. Increasing evidence identifies mitochondrial …
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Molecular studies of aggrecan : experiments and simulations
… tissues such as human intervertebral disc, the large self-assembling proteoglycans, aggrecan, are essential for the disc in resisting multiaxial compressive loads. Aggrecan degradation, a combinational result of abnormal and/or reduced cellular synthesis and proteolytic cleavage, leads …
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