Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"disaggregase"”.
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Investigating the protein quality control pathways that prevent protein aggregation in the social amoeba Dictyostelium discoideum
… Hsp101 was previously shown to act as a protein disaggregase of heat-induced polyQ foci. To further investigate Hsp101 as a polyQ disaggregase, I generated Hsp101 knockout Dictyostelium strains and found that Hsp101 knockout did not cause the accumulation of mutant Htt or prion aggregates under …
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Energy Stress Causes Chaperones to Assemble Into Cytoplasmic Complexes
… bacteria, plants, and fungi have a potent disaggregase, named Hsp104 in Saccharomyces cerevisiae. Recently, heat-induced aggregates, termed Q-bodies, were found to contain three molecular chaperones: Hsp70, Hsp104, and Hsp42. Their coalescence from small puncta into larger inclusions …
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Single Molecule Fluorescence Studies of Prions and Prion-like Proteins
… proteasome was demonstrated to possess a novel disaggregase function for αS fibrils and thus produce more seeds for further replication. It partially explains that αS aggregation in cells was found to replicate at a substantially faster rate than that in vitro. Determining the nature of the …