Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"disaccharides"”.
-
CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF CHONDROITIN SULFATE DISACCHARIDES
Glycosaminoglycans (GAGs) are heterogeneous polysaccharides comprising of repeating uronic acid and amino sugar disaccharide units. Recently, it was shown that the sulfate groups present in chondroitin sulfate GAGs (CS) encode important functional information for the regulation of physiological …
-
Physical Aging, Solubility, and Water Activity of Selected Disaccharides
For both experiments, the Tg onset, midpoint, and endpoint measured from the heat flow in SDSC, and the total and reversing heat flows in MDSC slightly increased with longer aging times and the Tg calculated for SDSC decreased whereas Tg calculated for MDSC slightly increased with aging time. In …
-
The design and synthesis of fluorescent peptides and disaccharides for tumour imaging.
Chapter 1: Peptide targeting of integrin αvβ3 Integrins are cellular surface receptor proteins involved in numerous cellular signalling and adhesion processes. The integrin αvβ3 subtype is up-regulated around sites of malignancy especially solid tumour masses. This is due to its expression on the …
-
Using Fluorescent Probes to Study the Location and Interaction of Disaccharides within Lipid Bilayers
… freezing. Our research aims to investigate other disaccharides with varying hydrophilicity as potential cryoprotectants for hydrated cells. In order to study the effectiveness of certain disaccharides as cryoprotectants, liposomes were used as a model membrane system. The location and interactions …
-
Fluorous- Phase Synthesis of Heparan Sulfate Disaccharides & Low-Molecular Weight Additives for Enhancing the Performance of Lithium-Ion Batteries.
… generation of diverse sulfoforms from heparan disaccharides using a fluorous tag to facilitate purification of highly charged intermediates, and their subsequent immobilizaion on substrates for affinity binding studies.</p> <p>A library of heparan disaccharide sulfoforms was prepared from a …
-
Effect of different disaccharides as energy supplements in tris-egg yolk semen extender on the quality of cryopreserved boer goat spermatozoa
… of Boer goat spermatozoa using different disaccharides concentrations as supplements in tris- egg yolk extender. Two experiments were carried out to investigate the effect of (a) addition of three disaccharides (maltose, sucrose and trehalose) and (b) disaccharides combination (maltose and …
-
Oligosaccharide Analysis via Anion Attachment Using Negative Mode Electrospray (ES) and Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry
… obtained in CID spectra of chloride adducts of disaccharides was used to differentiate anomeric configurations of disaccharides. Density functional theory (DFT) was employed to evaluate the optimized structures of chloride adducts of disaccharides. The formation and decomposition of chloride …
-
Structural and Metabolic Studies of Glycosaminoglycans (Sulfatase, Hydrazine, Mucopolysaccharidosis)
… method was used to convert reference GAGs to disaccharides which were reduced with NaB('3)H(,4) and separated by paper chromatography and anion exchange HPLC. Mono- and disulfated disaccharides from keratan sulfate (KS), the chondroitin sulfates (CS), and dermatan sulfate (DS) were identified. …
-
Novel tools for sequence and epitope analysis of glycosaminoglycans
… reacted with unsulfated chondroitin sulfate (CS) disaccharides from within a larger mixture. The resulting cyclic esters were easily detected in mass spectrometry (MS) using the distinct isotopic abundance of boron. Electrospray ionization tandem mass spectrometry (ESI-MSn) was employed to …
-
Development of transition state analogues targeting chitinases and oligosaccharyl transferase
… additional binding determinants. The pseudo-disaccharides containing an imino sugar were designed to target the oxocarbenium ion like transition state. The pseudo-disaccharides containing imino sugar were synthesized and evaluated at inhibitors for OT and chitinases.
-
Conformational analysis of diglycosyl disulphides containing ßS(1-1)S interglycosidic linkages
… analysis reveals that in the case of disaccharides containing unsubstituted glycosyl rings, good agreement with experimental nuclear overhauser effects (NOEs) and spin-spin coupling constants is obtained. However, for disaccharides containing substituted glycosyl rings poorer agreement …
-
Part I. Cleavage of Carbamates to Isocyanates: Selectivity, Extension to the Solid Support, and Synthesis of Multivalent Glycoforms With Inter-Saccharide Carbamate Linkages. Part II. Conjugation of Carbohydrate Moieties to a Rigid Aromatic Linker for the Study of Glycoside Internal Dynamics
… The results show that disaccharides with varying glycosidic linkage positions may be functionalized with the aromatic linker by reduction of the anomeric azide group and acylation. With the completed synthesis of the desired glucopyranosyl glucopyranoside-linker …
-
Chemistry of oxa- and aza-bicyclic(4.1.0)heptenes, total synthesis of (+)-pancratistatin
… 6 and 7 could serve as useful new synthons for C-disaccharides and Amaryllidaceae alkaloid syntheses. The utility of synthon 7b has been demonstrated by a concise enantiocontrolled synthesis of (+)-pancratistatin (9). The key step involved the S<sub>N</sub>2 opening of 7b with the aryl …
-
Role of labellar and ovipositor taste sensilla of Drosophila suzukii in host recognition: a morpho-functional and behavioural approach.
… sensilla stimulated with metabolizable mono- and disaccharides (maltose, sucrose, trehalose, glucose, fructose) and non-metabolizable sugars (arabinose, sucralose); the response to maltose and sucrose was stronger than to trehalose and to all monosaccharides, and that to sucralose was lower than …
-
FROM GENE TO STRUCTURE: Formation of Iduronic Acid in Dermatan Sulfate by Two DS-epimerases
… of sequences of iduronic acid containing disaccharides separated by stretches of glucuronic acid containing disaccharides. The former are also commonly associated with sulfation in the 4-O-position of N-acetylgalactosamine suggesting that there is interplay between sulfation and …
-
Structure and Metabolism of Heparin and Heparan Sulfate
… pH 1.5. The oligosaccharide products, primarily disaccharides and tetrasaccharides, were then end-labeled by reduction with sodium borotritide and purified to homogeneity using a combination of BioGel P-2 chromatography and strong anion exchange HPLC. The unknown components of both the …
-
Analysis of the Structural Units of Sulfated Glycosaminoglycans by High Performance Ion Exchange Chromatography
… two-L-iduronic acid-containing monosulfated disaccharides, 4-O-((alpha)-L-idopyranosyluronic acid)-6-O-sulfo-2,5-anhydro-D-mannitol (IMS) and 4-O-(2-O-sulfo-(alpha)-L-idopyranosyluronic acid)-2,5-anhydro-D-mannitol (ISM), and a single disulfated disaccharide, …
-
Studies in synthetic carbohydrate chemistry: Part 1. Nitromethane cyclization of sugar polyaldehydes with a view to the synthesis of nitrocyclodextrins. Part 2. Approaches to the synthesis of 2-(R)-fluoro-daunosamine, a carbohydrate moiety for an antitumor drug.
… heptoseptanosides, 3,3'-dideoxy-3,3'-dinitro-disaccharides, and "nitro 6-deoxy-beta-cyclodextrin", respectively. Chapter 1. Methyl 5,7-O-benzylidene-3-deoxy-3-nitro-alpha-D- glycero-D-ido-heptoseptanoside was debenzylidenated, and the resulting nitrotetrol was acetylated. A twofold reductive …
-
ΔΙΗΛΕΚΤΡΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΚΑΤΑΣΤΑΣΗΣ ΤΟΥ ΝΕΡΟΥ ΣΕ ΥΔΑΤΙΚΑ ΔΙΑΛΥΜΑΤΑ ΚΑΙ ΥΔΑΤΩΜΕΝΑ ΣΤΕΡΕΑ ΔΕΙΓΜΑΤΑ ΜΟΝΟ-ΚΑΙ ΔΙ-ΣΑΚΧΑΡΙΤΩΝ
… MANNOSE, RIBOSE, AND ARABINOSE AND THE DISACCHARIDES CELLOBIOSE, LACTOSE, AND MALTOSE, IN THE TEMPERATURE REGION OF 80-300K AND CONCENTRATIONS BETWEEN 0 .0003-15 MOL/LT, AND OF THE HYDRATED SOLID SAMPLES OF GALACTOSE AND MALTOSE IN THE RANGE OF HYDRATION H=0.8-20.2% AND THE SAME …
-
Untersuchungen zum Einfrier- und Auftauverhalten pharmazeutischer Humanproteinlösungen im Großmaßstab
… could be obtained by the addition of disaccharides or the replacement of the existing buffer media. Results and Conclusions The KVS-System is a completely new system for freezing and thawing of therapeutic protein solution in industrial scale. The Systems provides the possibility to …
Page 1 of 3