Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"dipyridamole"”.
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Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues
… and targets. The nucleoside transport inhibitor dipyridamole (<strong>DPM</strong>) showed potent chemopreventive activity against JB6 P<sup>+</sup>cells (tumor promotion sensitive). To probe the effects of <strong>DPM</strong> structural features on its antitumor promotion activity, the …
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Computer-Aided Drug Design and Discovery, Screening and Synthesis of Small Molecule Inhibitors of Nucleoside Transporters
… for biological testing. The NBMPR analogue and dipyridamole analogue hENT1 pharmacophores were compared to each other and to a combined pharmacophore for hENT1. The dipyridamole analogue pharmacophore better predicted non-nucleoside small molecule inhibitors, and as such appears to be the better …
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Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… (CUR), indomethacin (IND), flutaminde (FLU), dipyridamole (DIP), griseofulvin (GRI)] in absence and presence of four different polymers [i.e. polyethylene glycol (PEG), eudragit EPO (EPO), hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP)] in various drug-polymer ratios were …
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Mechanisms of ion channel activation in primary cultured and clonal cell lines
… B, or generation of membrane tension by dipyridamole failed to elicit significant increases in cell chloride permeability. The mechanism of current activation is as yet undetermined. The currents were effectively inhibited by the chloride channel inhibitors NPPB and DIDS but resistant to …
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A study of the binding of anti-aggregatory substances to platelet bound plasma proteins.
… was placed on the study of the binding of dipyridamole (DPD) and its analogues. The data obtained from the above experiments was compared with that obtained from the classical methods of equilibrium dialysis, dynamic dialysis, and continuous ultrafiltration and used to set up a number of …
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Peri-operative cardiac morbidity: prediction, prevention and the novel role of B-type natriuretic peptide
… time are dobutamine stress echocardiography and dipyridamole thallium scanning. However they are expensive, time consuming and have shown poor positive predictive ability, even in high risk cohorts. Few studies have studied the usefulness of biochemical markers in the prediction of post-operative …
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Biochemische Charakterisierung des ADP-Rezeptors P2Y12 und pharmakologische Therapiekontrolle von Thrombozytenfunktionshemmern
Die Bedeutung der cAMP- und cGMP-abhängigen Proteinkinase für die Hemmung der Plättchenaktivierung und -aggregation ist gut beschrieben. Zahlreiche fundamentale Plättchenantworten wie die Erhöhung der intrazellulären Calciumkonzentration, die Exposition von Adhäsionsrezeptoren und die …