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Showing 1 to 20 of 148 for “"diphosphate"”.
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Guanosine 5'-diphosphate 3'-diphosphate (ppGpp), guanosine 5'-diphosphate 3'-monophosphate (ppGp) and antibiotic production in Streptomyces clavuligerus
… Low levels of intracellular guanosine 5'-diphosphate 3'-diphosphate (ppGpp) were detected at D= 0.02 h' in continuous culture in all media. Low levels of intracellular guanosine 5 '-diphosphate 3 '-monophosphate (ppGp) were detected at D=0.02 if' in carbon- and nitrogen- limited media. …
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Purification of uridine diphosphate glucuronyltransferase
… the toxicant, enhancing its elimination. Uridine diphosphate glucuronyl transferase (UDPGT) is one microsomal enzyme involved in phase II reactions. It catalyzes the conjugation of toxic compounds with glucuronic acid in reactions in which uridine diphosphate glucuronic acid (UDPGA) is the donor …
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Functional and structural characterization of the mevalonate diphosphate decarboxylase and the isopentenyl diphosphate isomerase from Enterococcus faecalis
… faecalis;</em> one is the mevalonate diphosphate decarboxylase (MDD) in the mevalonate pathway, and the other one is the isopentenyl diphosphate isomerase (IDI), which is downstream of MDD. Functional and structural studies on the mevalonate diphosphate decarboxylase from …
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Fructose Diphosphate Aldolase Homologs in Embryological Development
Made available in DSpace on 2014-12-09T17:35:27Z (GMT). No. of bitstreams: 1 6604318.pdf: 7150359 bytes, checksum: 4dfdf1c874facc8f02d2ef5633cd55ef (MD5) Previous issue date: 1965
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Fructose 1,6-diphosphate ameliorates UV-induced skin inflammation
"Fructose 1,6-diphosphate (FDP)는 해당과정 (glycolysis)상의 고에너지 대사 중간체로서 당대사와 관련된 여러 효소들의 allosteric regulator로서 작용할 뿐만 아니라 심혈관계 보호작용 등의 다양한 생리활성을 지니고 있는 것으로 알려져 있다. 피부세포에서는 최근 human keratinocyte cell line (HaCaT)에서 FDP가 UVB 유도 세포내 H2O2 및 prostaglandin 생성을 유의적으로 억제한다고 보고된 바 있다. 본 연구에서는 FDP가 자외선에 의해 유도되는 …
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Characterization of ribonucleoside diphosphate reductase from Thermoplasma acidophila
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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Physiological and Biochemical Properties of Soybean Ribulose Diphosphate Carboxylase
Made available in DSpace on 2015-05-14T14:56:21Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7500347.PDF: 5565996 bytes, checksum: 4cbb852eb6f9569fac4076c5dca99e6a (MD5) Previous issue date: 1974
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Investigation of the Evolutionary Aspects of Thiamin Diphosphate-Dependent Decarboxylases
Thiamin diphosphate (ThDP)-dependent enzymes catalyze a wide range of reactions including the oxidative and nonoxidative decarboxylation of 2-keto acids, carboligation reactions, the cleavage of C-C bonds, and the formation of C-S, C-N, and C-O bonds. Surprisingly, given this diversity, all …
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A Comparative Study of Fructose Diphosphate Aldolases Isolated From Rabbit Tissues
Made available in DSpace on 2014-12-09T17:34:42Z (GMT). No. of bitstreams: 1 6402993.pdf: 4073346 bytes, checksum: 3e4d44ee6f793c1c2b4d92406b4ae8cc (MD5) Previous issue date: 1963
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PURIFICATION OF THE REGULATORY SUBUNIT OF RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE FROM CALF THYMUS
<p>The regulatory (B1) subunit of ribonucleoside diphosphate reductase from calf thymus has been purified to homogeneity, as demonstrated by the observation of a single band on SDS-polyacrylamide electrophoresis gels. The purification procedure involved the use of conventional techniques under …
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Modified Farnesyl Diphosphate, Germacrane, and Eremophilane Sesquiterpenes as Probes for Capsidiol *Biosynthesis
The final part of this thesis discusses the preparation and characterization of two deoxycapsidiols as well as a series of capsidiol analogs including epiaristolochene and two isomers. Overall, ten capsidiol derivatives were synthesized from capsidiol and sent to collaborators for various …
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Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation
<p>Many proteins require prenylation in order to be biologically functional. Some such proteins include the small Ras and Rho GTPase superfamilies, nuclear lamins A and B, and the kinesin motor proteins CENP-E and F. Prenyltransferase (PTase) inhibition is currently being explored as a possible …
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Synthesis and Evaluation of Aziridine Analogs of Presqualene Diphosphate as Squalene Synthase Inhibitors
… inhibitory activities of these novel aziridine diphosphate and methanediphosphonates towards squalene synthase compared to the analogous acyclic azabifarnesyl diphosphate may indicate a bridged non-classical, protonated cyclopropane intermediate in the formation of presqualene diphosphate.
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Stereochemistry and Mechanism of the Enzyme-Catalyzed Cyclization of Geranylgeranyl Diphosphate to (-)-Abietadiene
"A novel double labelling experiment involving (15S,17 E)-[15-3H1,17-2H1] CPP gave [16-3H1,16-2H1] abietadiene where the stereochemistry of the methyl was established as R by degradation and enzymatic analysis of the generated chiral methyl acetic acid. This indicated a surprising syn facial …
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
The broad, long-term objective of this research is to develop drug leads for new antibiotics, antiparasitics, and cancer chemotherapeutics. Two main areas of focus are inhibition of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and …
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