Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"dipeptidyl peptidase-IV"”.
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Chromogenic detection of dipeptidyl peptidase IV (DPP-IV) activity using peptide-functionalized gold nanoparticles
… for biosensing, bioimaging and drug delivery. This thesis presents a body of original research describing the synthesis, characterisation and development of a novel and convenient biosensing assay for detection of dipeptidyl peptidase IV (DPP-IV) enzyme activity using peptide …
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Anti-Diabetic and Anti-Obesity Activities of Cocoa (Theobroma cacao) via Physiological Enzyme Inhibition
… cocoa's anti-diabetic and anti-obesity bioactivities, such as inhibition of certain enzymes in the body. Polyphenol profiles, protein-binding abilities, presence of compounds termed oxidative polymers, and abilities to inhibit α-glucosidase, pancreatic α-amylase, lipase, and dipeptidyl …
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Production, characterization and evaluation of anti-diabetes peptides from proteins of improved common bean (Phaseolus vulgaris L.) cultivars using bioinformatic tools, enzymatic systems, and in vitro and in vivo models
… per year in the US alone. The use of alternative plant based treatments has the advantage of no side effects and could reduce treatment cost. Common beans health benefits are attributed to bioactive compounds; including resistant starch and oligosaccharides that contribute to dietary fiber; …
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Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
… men. Men who fail standard-of-care androgen deprivation therapy (ADT) and progress to metastatic castration resistant prostate cancer (mCRPC) are left with few therapeutic options. Current second line therapies only provide a small survival benefit and there is a critical unmet need for new and …
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Anthocyanins and proanthocyanidins from blueberry and blackberry fermented beverages to reduce inflammation and type-2 diabetes: a comprehensive in vitro and in vivo evaluation
… vegetable intake leading to postprandial oxidative stress and inflammation. Berries are one of the richest dietary sources of polyphenolic compounds associated with decreased markers of chronic inflammation and decreased risk for type-2 diabetes, specifically anthocyanins (ANC) and …
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Physicochemical characterization of ten blackcurrant (Ribes nigrum) cultivars, their bioactivity related to type 2 diabetes and inflammation, and chemical changes after lactic acid fermentation
… industry. However, new fungus resistant cultivars of blackcurrants have been created, and the high amounts of bioactive compounds, vitamins, minerals, and antioxidants in the currants, have started to create growing interest in developing the U.S. blackcurrant industry. Fermentation of berry …
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Cardiovascular Effects of GLP-1 and Glucagon Dual Receptor Agonism in Humans
… impaired insulin secretion. 415 million adults live with T2DM worldwide. It is a growing global health problem, closely linked to the increasing prevalence of obesity. The numbers living with T2DM is expected to increase to 642 million by 2040 and estimates suggest up to 12% of global health …
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Developmental Regulation of the Expression of Nutrient Transporter and BrushBorder Membrane Hydrolase Genes in the Small Intestine of Piglets
The objective of this study was to evaluate developmental regulation of the expression of nutrient transporter and brushborder hydrolase genes in the small intestine of piglets. Seventy piglets from seven sows were killed at birth (d 0), during suckling (d 1, 3, 7, 14, 21) and postweaning (d 22, …
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Bioactive peptides from purified and digested adzuki bean (Vigna angularis) β-vignin on type-2 diabetes-related pathways: effect and mechanism of action in a liver model under healthy and insulin-resistant states
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01