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Showing 1 to 20 of 116 for “"dioxygenase"”.
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Characterisation of a recombinant human cysteine dioxygenase
Cysteine Dioxygenase is an enzyme that catalyses the reaction of cysteine to cysteinesulfinic acid and is thought to regulate the intracellular concentrations of its substrate. The enzyme may also be involved in the oxidation of exposed sulfidrils of protein and by implication, involved in cell …
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Engineering of Aniline Dioxygenase for Bioremediation and Industrial Applications
Another round of saturation mutagenesis on active site residues with 1-K31 as parent followed by random mutagenesis yielded the mutant 3-R21. Whole cell activity of 3-R21 for AN, 24DMA and 2IPA were 27.7, 9.8, and 12 nmol/min/mg protein respectively. The activities of 3-R21 for AN, 24DMA and 2IPA …
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Structure guided discovery of inhibitors of indoleamine 2,3-dioxygenase (IDO1)
The enzyme indoleamine 2,3‐dioxygenase‐1 (IDO1) plays a critical role in the regulation of the immune system. IDO1 expression is commonly upregulated in cancer, resulting in a suppressed immune system in patients. Clinical observations that patients with high IDO1‐expressing tumours have a poor …
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Alpha-Dioxygenase aus Erbsen - Studien zu Expression und Enzym-Substrat-Interaktion
Das Enzym alpha-Dioxygenase (alpha-DOX) aus Erbsen (Pisum sativum) wurde mit folgenden Zielsetzungen untersucht: Isolierung und Charakterisierung der für die P. sativum alpha-DOX codierenden cDNA, Überproduktion der P. sativum alpha-DOX in Escherichia coli und nachfolgende Isolierung, Untersuchung …
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Design and Synthesis of Hydroxylamine Derivatives as Indoleamine - 2,3 - Dioxygenase Inhibitors
… research describing therole of indoleamine 2,3-dioxygenase (IDO) and its mechanism of action suggests that the inhibition of IDO with small molecule inhibitors, especially in conjunction with chemotherapy, can provide an effective and novel cancer treatment strategy. This inspired our search for …
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Biochemical and Structural Studies of AlkB: A 2-oxoglutarate Iron(II) Dependent Dioxygenase
… a direct repair 2-oxoglutarate iron-II dependent dioxygenase that oxidizes alkyl lesions occurring on the N1 position of purines and the N3 position of pyrimidines in both DNA and RNA. AlkB preferentially repairs 1-methyladenine and 3-methylcytosine lesions, but it is capable of repairing …
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MOLECULAR CHARACTERIZATION AND EXPRESSION OF GENTISATE 1,2-DIOXYGENASE FROM PSEUDOMONAS ALCALIGENES NCIB 9867
Gentisate 1,2-dioxygenase (GDO, EC 1.13.11.4) utilizes Fe2+ as a cofactor in the aromatic ring cleavage reaction of gentisate, yielding maleylpyruvate as the ring fission product. Mutant gentisate 1,2 dioxygenases were generated by both random and site directed mutagenesis of the gene cloned from …
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The production and synthetic utility of the dioxygenase-derived metabolites of substituted aromatics
The substrate scope and selectivity of toluene dioxygenase overexpressed in E.coli JM109 (pDTG601A) was investigated with series of ortho-halobenzoates and para-substituted arenes. Palladium-catalyzed carbonylation methodology was developed to convert halogenated cis-dihydrodiol metabolites to the …
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Investigation of phosphonate biosynthesis: I. Structure of dehydrophos II. Mechanism of hydroxyethylphosphonate dioxygenase
… into the mechanism of hydroxyethylphosphonate dioxygenase. Dehydrophos was discovered as a secondary metabolite of Streptomyces luridus and was shown to have broad spectrum activity against both Gram-negative and Gram-positive bacteria. Chemical synthesis of the originally proposed structure …
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The Role of Carotenoid Cleavage Dioxygenase 4 in Flower Color of the Allopolyploid Brassica napus
… subgenomic interactions. <em>CAROTENOID CLEAVAGE DIOXYGENASE</em> 4 (<em>CCD4</em>)<em> </em>is known to play a major role in determining flower color phenotype of carotenoid-synthesizing angiosperms. Here, we investigate the genetic and epigenetic role of <em>CCD4 </em>orthologs and their role in …
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The roles of indoeamine-2,3-dioxygenase 1 and 2 during TMEV- and kainate-induced ictogenesis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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Synthesis And Characterization Of Nickel Complexes With Relevance To Nickel Acireductone Dioxygenase And Nickel Superoxide Dismutase
… to the active site of Ni(II) acireductone dioxygenase (Ni-ARD) and Ni(II) superoxide dismutase (Ni-SOD). Acireductone dioxygenases (ARDs) are a unique set of enzymes found in the methionine salvage pathway that catalyze the oxidation reaction of acireductone (1, …
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Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… The tryptophan degrading enzyme indoleamine 2,3-dioxygenase 1 (IDO1) has also been implicated in neurodegenerative disease and depression. IDO1 activity increases kynurenine concentrations in circulation and brain tissue following LPS administration. Further, IDO1 has been shown to be necessary …
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Bakterielle 2,4-Dioxygenasen: Untersuchungen zur Aufklärung des Katalysemechanismus der cofaktorfreien 1H-3-Hydroxy-4-oxochinaldin 2,4-Dioxygenase
Die cofaktorfreie 1H-3-Hydroxy-4-oxochinaldin-2,4-Dioxygenase (Hod) katalysiert die 2,4-oxygenolytische Spaltung ihres N-heterozyklischen Substrates zu Anthranilat und CO. Mittels Sequenz-Alignments und Struktur-Vorhersagen wurde Hod der Superfamilie der Alpha/Beta-Hydrolasen zugeordnet. Kinetische …
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Understanding polycyclic aromatic hydrocarbon degradation by soil microbial communites: the concentration and distribution of aromatic dioxygenase genes
… following thesis therefore compares two aromatic dioxygenase genes, nidA and nahAc, which confer the ability for the bacteria carrying the genes to metabolize polycyclic aromatic hydrocarbons (PAHs), persistent pollutant byproducts of coal coking. The deposition of PAHs influences the development …
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Characterization of 5-methylcytosine dioxygenase Tet2 and rescue of mutant Tet2 activity by using turbo co-substrate
… sequential oxidation by ten-eleven translocation dioxygenases (TET1-3), followed by thymine-DNA glycosylase-dependent base excision repair. Inactivation of the TET2 gene due to genetic mutations or other epigenetic mechanisms is associated with poor prognosis in patients with diverse cancers, …
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Structural studies of Burkholderia pseudomallei invasion protein D (BipD), 2,4'-dihydroxyacetophenone dioxygenase (DAD) and L-threonine dehydrogenase (TDH)
… in vivo.<br/><br/>2,4’-Dihydroxyacetophenone Dioxygenase (DAD) from Alcaligenes sp. is of interest for quite a different reason. Aromatic hydrocarbons, are especially damaging to the environment because they are not naturally degraded. The expression and purification protocols for DAD have now …
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Dietary tomato carotenoids and β-carotene-15,15'- dioxygenase (Bco1) genotype alter androgen metabolism, lipid metabolism, and prostate cancer progression in mice
β-carotene-15,15'-dioxygenase (BCO1) cleaves dietary carotenoids at the central 15,15' double bond, most notably acting on β-carotene to yield retinal. Much work has gone into the description of enzymatic carotenoid cleavage activities of the enzyme, but although pleiotropic effects of Bco1 loss on …
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Investigating the Role of Indoleamine 2,3-Dioxygenase 1 and Transforming Growth Factor Beta 1 in Rebound Immune Suppression Following Chemotherapy in Osteosarcoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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