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Showing 1 to 20 of 197 for “"diol"”.
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Clathration by diol hosts : thermodynamics and structure
Inclusion properties of the following seven diol host compounds were investigated: Host 1 9,9'-bis(9,91-dihydroxy-fluorene) Host 2 1, 1'-binaphthyl-2,2'-bis( diphenylhydroxymethyl) Host 3 2,2'-bis(9-hydroxy-9-fluorenyl)biphenyl Host 4 trans-9, 10-dihydroxy-9,10-diphenyl-9, 10-dihydroanthracene Host …
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Structure and thermodynamics of Diol inclusion compounds
This work is predominantly concerned with the structural analysis of the coordinatoclathrates formed by the host compound trans-9,10-dihydroxy-9,10-diphenyl- 9,10-dihydroanthracene (1) with compounds containing neutral nitrogen atoms (Lewis bases). The structures of inclusion compounds with two …
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Structure and decomposition of diol inclusion compounds
The inclusion properties of the host, trans-9, 10-dihydroxy-9, 10-diphenyl-9,10- dihydroanthracene, with various guest molecules, namely cyclohexanone, 2- methylcyclohexanone, 3-methylcyclohexanone and 4-methylcyclohexanone, were investigated. The host to guest ratios were determined by programmed …
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Structure and reactivity of diol host-guest compounds
The crystal structures of trans-9, 10-dihydroxy-9, 10-diphenyl-9, 10- dihydroanthracene with various guest molecules have been determined by X-ray diffraction. The guests were 2-butanone, 4-vinylpyridine, 4-methylpyridine and 2-methylpyridine. The host to guest ratios were determined by …
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Development of oxygenase biocatalysts for the production of synthetically useful cis-diol compounds
The cis¬-dihydrodiol compounds, produced by the highly regio- and stereo-selective Rieske non-heme iron oxygenases, such as toluene dioxygenase (TDO), are versatile synthons for chiral, asymmetric synthesis. The cis-dihydroxylation of ortho- and meta-substituted phenols by TDO produce cyclohexenone …
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Quantification of benzo[a]pyrene-diol-epoxide adducts by laser-induced fluorescence spectroscopy
… used to quantify adducts of benzo[a]pyrene-7,8-diol-9,10- epoxide (BPDE) in human lung tissue and human bronchial epithelial cell histones and DNA and in human serum albumin. The presence of BPDE adducts in human lung tissue and human bronchial epithelial cell histones and DNA was proven by …
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Asymmetric cyclopropanation via catalysts incorporating the 1,4-diol ligands and the newly designed dioxaborolane /
The development of new methodology for the asymmetric synthesis of chiral organic compounds is a major focus in modem organic chemistry. The use of chiral catalysts is replacing chiral auxiliaries as a new tool for synthetic chemists. An efficient chiral catalyst allows for large quantities of …
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A kinetic investigation of boronic acid/diol interactions and pattern-based recognition of [alpha]-chiral carboxylates
… cyclic boronate esters with of 1,2- and 1,3-diols, polyols, catechols, and α-hydroxycarboxylic acids, boronic acids have found applications spanning from lipid transport to Hydrogen fuel cells. The majority of the work presented in this dissertation will be aimed at gaining a better …
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Understanding and optimisation of non-conventional emulsions
… is concerned with understanding the effect of diols on emulsion properties and to use knowledge gained to optimise emulsions containing them. The project was sponsored by GlaxoSmithKline, a world leading pharmaceutical company, whose interest is in using the knowledge to help in research and …
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The modification of brucine derivatives as chiral ligands and its application in the asymmetric synthesis
… the use of a multifaceted chiral ligand, brucine diol, under different reaction conditions to produce various optical isomers is described. In Chapter 1, the generation of a number of brucine derivatives is described. Taking the advantage of brucine-diol's excellent molecular recognition …
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Structure and reactivity of selected organic inclusion compounds
… 1,1 ,6,6-tetraphenylhexa-2,4- diyne-l,6-diol and cyclotriveratrylene (2,3,7,8,12,13-hexamethoxy-5,lO-dihydro- 15H-tribenzo[ a,d,g]cyclononene) was studied. Small organic guests were complexed with these hosts and their crystal structures determined. The stability and reactivity of these …
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Synthesis and structure-activity studies of skeletally modified estradiol analogues
… of 14,17α-ethanoestra-l,3,5(10)-triene-3,17β-diol were examined, with the purpose of determining the influence of configurational inversion at C-8, C-9 or C-13 upon the high oral estrogenicity associated with introduction of a 14, 17-ethano bridge into the estradiol skeleton. …
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Structures and thermal stability of selected organic inclusion compounds
… of 1,1 ,6,6-Tetraphenyl-hexa-2,4-diyne-1 ,6-diol and 5-(3,5- Dicarboxyphenylethynyl)-isophthalic acid hosts with various guests have been elucidated. Depending on their structural properties and the way in which the host components pack, the guests may become trapped in spaces or voids, …
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Exploring the potential application of glucuronides as a prognostic biomarker for disease.
… glucuronide (ADT-g), androstane-3α, 17β-diol glucuronide (3α-diol-G), and androstane-3a, 17b-diol-17 glucuronide (3α-diol-17G), when prostate cancer is influenced by gene variants. In type 2 diabetes, influenced by lifestyle, three glucuronides are associated with the disease: …
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Biotransformation studies on tobacco cembranoids using plant cell cultures
… into three parts: 1) Biotransformation of the diols 1 and 2 using the TRP4a cell line. 2) Biotransformation of the diol 1 using the T-43-T cell line. 3) Biotransformation of cembranoid analogues using the T-43-T cell line. Incubation of the diol 1 with the growing cells of TRP4a and with cells …
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Phytochemical studies on traditional medicinal plants with antimalarial activities
… three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( …
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Konstruktion und Durchmusterung von Metagenombanken: Identifizierung und Charakterisierung von Genen und Genprodukten von am Polyol-Stoffwechsel beteiligten Oxidoreduktasen und Coenzym B12-abhängigen Dehydratasen
… Gene für Koenzym B12-abhängige Glycerin-und Diol-Dehydratasen wurden vier sogenannte Metagenom-Banken hergestellt. Als Proben wurde Boden eines Zuckerrübenfeldes, Sediment des Flusses Grone (beide nahe Göttingen, Deutschland), Sediment des Solar Lake (Ägypten) und Sediment des Golfs von Eilat …
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Radical cyclization approach to a chemoenzymatic synthesis of morphine
… silicon-containing epoxide [figure 1], the diene diol [figure 2], and the known oxazolone [figure 3]. See: Figures 1, 2, and 3 Diene diol [figure 2] was isolated in the amount of 200 mg/L from the fermentation of (2-bromoethyl)benzene by Pseudomonas putida 39/D (Pp 39/D) and the absolute …
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