Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"dilated cardiomyopathy"”.
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PATHOGENIC MECHANISMS OF TRUNCATED TITIN IN DILATED CARDIOMYOPATHY
… titin (TTNtv) have long been known to cause dilated cardiomyopathy (DCM) and, recently, peripartum cardiomyopathy (PPCM). How these genetic variations lead to the hypocontractility that is characteristic of DCM and PPCM has remained controversial due to lack of evidence supporting either …
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Surgical ventricular reconstruction for ischemic or idiopathic dilated cardiomyopathy
… this application to patients with idiopathic dilated cardiomyopathy (DCM). The purpose of this retrospective study was to analyze the clinical outcome and long-term survival of patients who underwent the Dor surgical ventricular reconstruction (SVR) procedure. <br>Methods: Mortality, cardiac …
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Prevalence, Outcome, and Predictors of Cardiorenal Syndrome in Children with Dilated Cardiomyopathy
… of CRS have not been reported in children with dilated cardiomyopathy (DCM).Methodology: Data from patients > 1 year of age with DCM enrolled in the Pediatric Cardiomyopathy Registry (PCMR) were assessed. CRS was defined as estimated glomerular filtration rate (eGFR) <90 ml/min/1.73m2 by …
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Mitochondrial Protein Expression in Natural and Induced Forms of Canine Dilated Cardiomyopathy
In conclusion, mitochondrial proteins associated with essential metabolic pathways were found to be altered in the myocardium of dogs with DCM. The altered mitochondrial proteins were mainly related to oxidative phosphorylation, but also included other elements of primary energy and other types of …
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Molecular genetics of arrhythmogenic right ventricular and dilated cardiomyopathy in South Africans
… Little is known about the molecular genetics of cardiomyopathy in Africans. Aims: to (I) determine the prevalence of desmosomal gene mutations in arrhythmogenic right ventricular cardiomyopathy (ARVC) and dilated cardiomyopathy (DCM) in desmosomal protein genes (i.e., plakophilin 2, desmocollin …
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Genetic Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo)
Dilated cardiomyopathy (DCM) or round heart disease is a muscle disease of the heart which is characterized by ventricular dilatation and abnormal systolic and diastolic left ventricular function. In animals, including turkeys and humans, DCM is the major cause of morbidity and mortality which …
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Effects of the MYH7 R369Q Dilated Cardiomyopathy-causing Mutation on Myosin Crossbridge Kinetics and Cardiomyocyte Contractility
… gene is a likely pathogenic variant of familial dilated cardiomyopathy (DCM). This mutation is located in loop 4 of β-myosin heavy chain actin-binding surface and may alter actin-myosin interaction that facilitates cardiomyocyte contraction. There are limited insights into the nature and …
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Candidate Gene Expression and SNP Analyses of Toxin-Induced Dilated Cardiomyopathy in the Turkey(Meleagris gallopavo)
Dilated cardiomyopathy (DCM), a heart disease, affects many vertebrates including humans and poultry. The disease can be either idiopathic (IDCM) or toxin-induced. Idiopathic DCM often occurs without a consensus cause. Though genetic and other studies of IDCM are extensive, the specific etiology of …
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An Assessment of the Molecular Basis of Toxin-induced Dilated Cardiomyopathy in an Avian Animal Model
Dilated cardiomyopathy (DCM), a disease of the myocardium, causes morbidity and premature death in humans and other domestic animals including turkeys. Though DCM results from many different factors including those that are unknown or idiopathic, genetic factor is a major cause of idiopathic DCM. …
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Agreement between gadolinium-enhanced cardiac magnetic resonance and electro-anatomical maps in patients with non-ischemic dilated cardiomyopathy and ventricular arrhythmias
… maps (EAM) of patients with non-ischemic dilated cardiomyopathy (NIDCM) and how it relates with the procedural outcome after catheter ablation of ventricular arrhythmias (VA). We identified 50 patients with NIDCM who underwent CMR and ablation for VA. LGE was detected in 16 patients (32%), …
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An Assessment of the Effects of Oxidative Stress and Dietary Antioxidants on Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo)
Dilated cardiomyopathy (DCM) or round heart disease is a muscle disease of the heart characterized by left ventricular dilatation and abnormal systolic and diastolic ventricular function. In animals, including turkeys and humans, DCM is a major cause of morbidity and mortality that results in heart …
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MRI determined tissue characterization of myocardial infiltration and fibrosis in cardiomyopathy
… There may be also conduction abnormalities. Dilated cardiomyopathy is a form of cardiomyopathy that is characterized by abnormal dilatation of the heart and subsequent heart failure. One of the characteristics of the cardiomyopathies and amyloidosis is the diffuse interstitial or replacement …
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Analysis of desmoplakin in arrythmogenic right ventricular cardiomyopathy
It has been shown that all forms of cardiomyopathy, including the dilated, hypertrophic, restrictive, and right ventricular arrhythmogenic forms, are found in African populations. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare muscle disease characterised by fibrofatty replacement …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… pathway and its physiologic impact on congestive cardiomyopathy</strong></p> <p>Publication No.___________</p> <p>Eun Young Kim, M.S.</p> <p>Supervisory professor: Robert J. Schwartz, Ph.D.</p> <p>SUMOylation regulates diverse cellular processes including transcription, cell cycle, protein …
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Novel Phenotyping of the Myocardium by Diffusion Tensor Cardiovascular Magnetic Resonance
… was performed in controls and in patients with dilated cardiomyopathy (DCM), including recovered dilated cardiomyopathy (R-DCM) and congenital disease, as exemplified by situs inversus totalis (SIT). Two main DT-CMR sequences, stimulated echo acquisition mode (STEAM) and second-order …
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Towards the full molecular investigation of protein kinase a mediated catalysis by NMR spectroscopy.
… with forms of the fatal hereditary disease, dilated cardiomyopathy. The molecular basis of disease in this situation could result from irregularities in the association of these PLN mutants with PKA. The work presented here lays the foundation for obtaining the molecular details which govern …
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MOLECULAR DISSECTION OF CARDIOMYOPATHY
Hypertrophic (HCM) and dilated cardiomyopathy (DCM) are inherited cardiac conditions with marked genetic heterogeneity. The genetic aetiology of HCM and DCM in Singapore and European was broadly similar but Singapore Chinese HCM patients frequently have fewer clinically actionable disease variants, …
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Chronic Treatment of TMAO Undermines Mouse Cardiac Structure and Function in a Sex-specific Manner
… results showed signs of hypertrophic cardiomyopathy in TMAO-treated male hearts while female TMAO-treated hearts showed signs of dilated cardiomyopathy. Neither TMAO group showed signs of fibrosis. Overproduction of reactive oxygen species was only observed in male TMAO-treated hearts. …
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Sub threshold high frequency electrical field stimulation effect for angiogenesis and vegf expression in cardiomyocytes and heart tissue. Remodelling in the heart: impact of mechanical stretch, threshold and sub-threshold electrical stimulation on cultivated cardiomyocytes and sympathetic neurons /
… evaluate the role of autoantibodies in cases of dilated cardiomyopathy, inducing the expression of vascular endothelial growth factor in cardiomyocytes; to evaluate the effect of contraction and the secretion of vascular endothelial growth factor as a cell response to stretching. Investigate the …
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The Role of MCL-1 in the Heart: Gateway from Life to Death
… ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy preceded by loss of myofibrils and cardiac contractility, abnormal mitochondria ultrastructure, defective mitochondrial respiration, and impaired autophagy. Genetic ablation of both pro-apoptotic effectors (Bax and Bak) could …
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