Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"dihydropyridine"”.
-
1,1-enediamines and β-substituted enamines in heterocyclic synthesis
… enamines and cyanoacetamide. In one case a dihydropyridine was isolated. This dihydropyridine, on heating in acidic conditions, gave a pyridinone, which confirmed this dihydropyridine as an intermediate in this pyridine synthesis. A new synthetic method was used to make highly substituted …
-
Chemistry of the Degradation of Vinyl Polymers to give Carbon Fibre Precursors
… cyclisation results in a condensed 1 ,4.-dihydropyridine structure which, by analogy with the known chemistry of 1,4-dihydropyridines, will oxidise on exposure to air to a fully aromatic condensed pyrinoid system. This theory has been extended to cover the thermal and oxidative …
-
Spectroscopic studies of hydrophobic association of merocyanine dyes in cationic and anionic micelles
… (oxocyclohexadienylidene) ethylidene -1,4-dihydropyridine (MOED) are yellow, red, violet, or blue, in water, ethanol, acetone or pyridine respectively.<sup>1</sup> More striking effects are observed when aqueous solutions are diluted with various proportions of the organic co-solvents such …
-
Designing new chiral hydroxamic acid ligands for the asymmetric epoxidation reaction in water
… been prepared as precursors to the corresponding dihydropyridines. It was our initial intention to utilise these chiral dihydropyridines in the enantioselective reduction of imines. This would result in the formation of the desired chiral amine and a quaternary pyridinium salt, which could then be …
-
Yeast two-hybrid analysis of skeletal muscle triad junction proteins
… no strong interaction was detected between the dihydropyridine receptor (DHPR) II-III loop and the skeletal muscle ryanodine receptor (RyR); however, a possible weak interaction between physiologically important parts of the two receptors was investigated. In screens of a skeletal muscle cDNA …
-
Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
… release are the ryanodine receptor (RyR) and the dihydropyridine receptor (DHPR). The main proteins involved in calcium uptake are the fast and slow isoforms of sarco(endo)plasmic reticulum calcium ATPase (SERCA 1 and SERCA 2 respectively). Calsequestrin (Csq) and calmodulin (CaM) play regulatory …
-
Discovery and Characterization of Genes Involved in Muscle Calcium Handling
… a voltage sensor in the membrane, called the dihydropyridine receptor (DHPR), becomes activated and signals to the calcium release channel located in the membrane of the sarcoplasmic reticulum (SR), called the ryanodine receptor (RyR). When the RyR channel is activated, calcium is released …
-
The effects of amlodipine on exercise performance in mild to moderate essential hypertensives
The effect of the long acting dihydropyridine calcium channel antagonist, amlodipine, on the exercise performance of hypertensive patients is not known. The aim of this study was to determine the effects of amlodipine on maximal (MAX), prolonged submaximal (PSX) and on skeletal muscle function …
-
Myocardial Contractility in Fetal Sheep Exposed to Long-term Hypoxia at High Altitude : Activator Calcium and Beta-adrenergic Receptor Function
… papillary muscles. In addition, we quantified dihydropyridine (DHPR), ryanodine (RyR), and β-adrenergic receptor densities, and measured basal and stimulated intracellular cAMP levels. In hypoxic fetuses, left ventricular wet weight was unchanged, but right ventricular weight was ~20% lower …
-
Anion Exchange Membranes (AEMs), based on Polyamine Obtained by Modifying Polyketone, for Electrochemical Applications
… to form N-substituted pyrrole crosslinked with dihydropyridine units. Scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction techniques were also used to study the morphological, thermal, and structural characteristics of the modified polyketone, as well as the …
-
Towards understanding EC coupling protein expression with age
… calcium channels facilitating EC coupling, the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR1), perhaps due to a decrease in expression of the DHPR alpha1s subunit which has been demonstrated in rodents. Changes in DHPR beta1a subunit expression have also been reported in aging …
-
Towards understanding EC coupling protein expression with age
… calcium channels facilitating EC coupling, the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR1), perhaps due to a decrease in expression of the DHPR alpha1s subunit which has been demonstrated in rodents. Changes in DHPR beta1a subunit expression have also been reported in aging …
-
Characterisation of the cross-linking and calcification associated with glutaraldehyde-treated cardic bioprostheses.
… products incorporating pyridinium and dihydropyridine ring structures. Some of these structures are in agreement with the literature, whilst others are essentially new structures that have never been proposed. Glutaric acid, used to mimic the oxidation of glutaraldehyde that can occur …
-
Comparative effects of calcium channel antagonism and beta-1 selective blockade on exercise performance in physically active hypertensive patients
… was to compare the effects of isradipine, a dihydropyridine calcium channel antagonist, to those of atenolol, a β₁-selective antagonist, on maximal and submaximal exercise performance and on short duration high-intensity exercise in physically active hypertensive patients. The study design …
-
Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenal.
… side effects as in the case of existing dihydropyridine class of Ca2+ channel blockers. The second part of my thesis focused on genotyping and whole exome sequencing of 59 APAs from 52 patients, in order to identify further genes underlying primary aldosteronism. Mutations in previously …