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Showing 1 to 7 of 7 for “"dihydroorotate dehydrogenase"”.
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Targeting Plasmodium Falciparum Dihydroorotate Dehydrogenase (PfDHODH) for the Development of New Antimalarials
… a persistent challenge. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), which catalyzes the fourth rate-limiting step of the de novo pyrimidine synthesis, is a validated drug target, yet no inhibitor has surpassed Phase II clinical trials. Towards this goal, hit compound JT01, a …
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Genetic and Biochemical Characterization of the Heteromeric Dihydroorotate Dehydrogenase From Bacillus Subtilis
… per mol subunit. The holoenzyme possessed dihydroorotate:NAD+ oxidoreductase activity and could also reduce menadione and artificial dyes. Purified PyrDI also possessed DHOD activity but could not reduce NAD+. Compared to PyrDI, the holoenzyme had a greater than 20-fold smaller Km value for …
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Impaired virulence factor production in a dihydroorotate dehydrogenase mutant (pyrD) of Pseudomonas aeruginosa.
… step in the pyrimidine pathway which encodes dihydroorotate dehydrogenase. The resulting mutant required pyrimidines for growth but produced wild type pigment levels. Since the pigment pyoverdin is a siderophore it may also be considered a virulence factor, other virulence factors were …
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On the Oxidative Half-Reaction of Plasmodium Falciparum Dihydroorotate Dehydogenase
… the organism is deficient in pyrimidine salvage. Dihydroorotate dehydrogenase (DHODH) is the flavoenzyme which catalyzes the fourth step in this pathway. The studies presented here describe the oxidative half-reaction of Pf DHODH where the enzyme, containing reduced falvin mononucleotide (FMN), is …
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Metabolomic Approaches in Parasitology
… and the impact of inhibiting the pathway enzyme dihydroorotate dehydrogenase (DHODH) and the polyamine biosynthesis pathway and routes to obtaining the pathway precursor L-ornithine. DHODH has recently been validated as a therapeutic target for malaria through clinical studies on the …
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
… which is known to be an inhibitor of the dihydroorotate dehydrogenase (DHODH) enzyme, proved to be the most potent (IC50~1.4μM) SOCE inhibitor among all the drugs tested, inhibitor of SOCE as it could suppress SOCE significantly at nanomolar dose. Next, selected drugs identified with SOCE …