Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"digoxin"”.
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Folate Receptor-Targeted Transplacental Delivery of Digoxin for the Treatment of Fetal Arrhythmia
… is typically treated with transplacental digoxin by maternal administration. However, maternal digoxin administration is associated with nausea, vomiting, heart block and sinus bradycardia. Additionally, placental efflux mechanisms limit the transfer of digoxin to the fetus. When …
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Alkalosis and digoxin effects on plasma potassium, ionic homeostasis and exercise performance in healthy humans
… the effects of a clinically relevant dose of digoxin administration on K+ regulation, during intermittent supramaximal finger flexion contractions (small muscle mass) and fatigue in healthy humans. Study 3 investigated the effects of digoxin on K+ regulation during progressive increasing …
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Digoxin and exercise effects on Na+,K+-ATPase isoform gene and protein expression in human skeletal muscle
… to be important for skeletal muscle performance. Digoxin is a specific inhibitor of the Na+,K+- ATPase and is used to treat patients with severe heart failure. This thesis investigated whether in-vivo inhibition of Na+,K+-ATPase by digoxin adversely effected muscle performance and Na+,K+-ATPase …
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Effects of exercise, renal disease, and digoxin on skeletal muscle Na+,K+-ATPase and related effects on plasma K+ and muscle performance
… – acute exercise, renal disease and digoxin. The related effects on plasma [K+] during exercise and on muscle performance were also examined. This thesis firstly investigated the acute effects of brief intense exercise on muscle Na+,K+-ATPase content and maximal activity (Study 1). …
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ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ PAF ΣΤΟ ΚΥΚΛΟΦΟΡΙΚΟ ΣΥΣΤΗΜΑ ΤΩΝ ΕΠΙΜΥΩΝ ΚΑΙ ΣΤΗ ΡΥΘΜΙΣΗ ΤΗΣ ΜΕΤΑΦΟΡΑΣ ΙΟΝΤΩΝ ΣΤΟ ΠΡΩΤΟΖΩΟ TETRAHYMENA PYRIFORMIS
… OF THE AGEPC ACTION TWO DRUGS (VERAPAMIL AND DIGOXIN) WERE USED AS POSSIBLE INHIBITORS AND WHICH ARE OFTEN USED IN CARDIAC DISEASES. IN THIS STUDY THE CELL OF THE PROTOZOO TETRAHYMENA PYRIFORMIS WAS USED. AFTER I.V. ADMINISTRATION OF AGEPC IN RATS, IT CAUSES HAEMOCONCENTRATION, ABRAPT FALL OF …
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Uptake and transport of orally-deliverable drugs across caco-2 cell monolayers:the effect of lipid formulations
… of mannitol, propranolol, glutamine and digoxin was measured in the presence and absence of Iiposome formulations to establish changes in absorption resulting from the presence of lipid formulations. Incorporation of the four hydroxybenzoates was shown to be influenced by a number of …
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Synchronised capacitor discharge in the management of cardiac arrhythmias with particular reference to the haemodynamic significance of atrial systole
… quinidine, atropine, prostigmine, prednisone and digoxin. A second stage, total correction for tetralogy of Pallot had been successfully performed two years before by Sir Russell Brock and the tachycardia followed a sudden blow on the cheat at his school. Further drug treatment to the point of …
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Clinical characteristics, causes, adherence to heart failure treatment guidelines and mortality of patients with acute heart failure: the Groote Schuur Hospital experience
… rate of β-blocker, aldosterone antagonist and digoxin use. Rehospitalisation at 180 days occurred in 25.2%. In-hospital mortality was 8.4 % and the case fatality rate at six months was 26.1%. Conclusion: In Cape Town the main causes of AHF are cardiomyopathy, IHD and RHD. AHF affects a young …
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Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
… identified HIF inhibitors from natural sources - digoxin and doxorubicin. The results show that honokiol has a better safety to efficacy profile as a HIF inhibitor than digoxin and doxorubicin. Therefore honokiol was chosen as candidate molecule for further clinical evaluation for the treatment of …
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The Temporal Nature of Ectopic Activity in Guinea Pig Ventricular Myocardium
… of non-ectopic activity. Hypercalcemia and digoxin both produced significantly earlier beats with wider QRS durations, suggestive of ectopic activity. Increasing pacing further shortened RCL during digoxin + hypothermia, a mechanistic identifier of ectopic activity. When tested against a …
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Long Term Therapy of Chronic Heart Failure
… with supporting therapies like ivabradine and digoxin. It also examines emerging treatments such as telemedicine, precision medicine, and gene therapy and discusses ongoing challenges like patient compliance, healthcare access, and the cost of care.I chose this topic due to my interest in …
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Gene regulation and hypertroipc responses in age-matched control and STZ-treated rats
… the pharmacological effect of either digoxin or captopril, at a dose of 10 3 M, on the force of contraction of isolated healthy age-matched control intact perfused hearts. The results show that the cardiac glycoside, digoxin evoked a small increase in the force of contraction of the …
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ΜΕΤΡΗΣΗ, ΑΠΟΜΟΝΩΣΗ, ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΜΕΡΙΚΗ ΤΑΥΤΟΠΟΙΗΣΗ ΟΥΣΙΩΝ ΤΟΥ ΠΛΑΣΜΑΤΟΣ ΠΟΥ ΑΝΤΙΔΡΟΥΝ ΜΕ ΑΝΤΙΣΩΜΑΤΑ ΔΙΓΟΞΙΝΗΣ
… ΑΝΤΙΣΩΜΑΤΑ ΔΙΓΟΞΙΝΗΣ. ΕΠΙΒΕΒΑΙΩΘΗΚΕ Η ΠΑΡΟΥΣΙΑ DIGOXIN LIKE IMMUNOREACTIVE SUBSTANCES (DLIS) ΣΤΟΝ ΟΡΟ ΜΕ ΡΑΔΙΟΑΝΟΣΟΧΗΜΙΚΕΣ ΜΕΘΟΔΟΥΣ (RIA). ΒΡΕΘΗΚΕ ΟΤΙ Η RIA ΤΗΣ ΕΤΑΙΡΕΙΑΣ ΝΕΝ ΕΙΝΑΙ Η ΕΚΛΕΚΤΙΚΟΤΕΡΗ ΓΙΑ ΠΡΟΣΔΙΟΡΙΣΜΟ DLIS. ΑΚΟΜΗ ΜΕΓΑΛΥΤΕΡΕΣ ΤΙΜΕΣ DLIS ΕΛΗΦΘΗΣΑΝ ΜΕ ΤΡΟΠΟΠΟΙΗΣΗ ΤΩΝ ΣΥΝΘΗΚΩΝ ΕΠΩΑΣΗΣ …
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The impact of hypoxia on nanomedicine uptake and efflux in human breast cancer cells
… cells, where HIF1α was partially inhibited by digoxin (p<0.001, Chapter 4). Exocytosis studies indicated that the preconditioned cells had a significantly increased nanoparticle efflux (up to 9%, p<0.001) when compared tonormoxic cells (Chapter 3). Overall, this thesis has demonstrated …
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Modulation of drug transport by citrus fruit juices
… cells supported the hypothesis. Bi-directional digoxin transport data across the MDR1-transfected L-MDR1 cells also produced a similar conclusion. The hypothesis could further be extended to the pOCT2-mediated transport in the LLC-PK1 cells. Data for the orange juice suggested that taxonomy, …
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Evaluation of a Special Teaching Program with Ambulatory Cardiac Patients
… and after their discharge. Three medications, digoxin (lanoxin), lasix, and nitroglycerin, were studied. The program for the experimental group included planned instruction and practice in self-administered medication while the patients were hospitalized.</p> <p>The program, planned by the …
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
… of the HIF pathway. Further, honokiol, digoxin, and doxorubicin, three recently identified HIF inhibitors from natural sources effectively blocked the expression of stem cell markers. These results present the possible cytological origin of neoplastic stromal cells in hemangioblastomas. …
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… xenobiotics such as verapamil, propranolol, and digoxin. Functionally, these changes were not found dependent on CYP-mediated biotransformation of parent compounds; rather, they appear driven more by proposed gut barrier compromise. In conclusion, gastrointestinal infection with C. rodentium …
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