Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"difluoromethyl ketones"”.
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Generating structural diversity in \(\alpha\)[alpha],\(\alpha\)[alpha]-difluoromethyl ketones
… the synthesis of \(\alpha\),\(\alpha\)-difluoroketones contained within a diverse array of molecular motifs. 1-(\(N\),\(N\)-Diethylcarbamoyloxy)-2,2-difluoro-1-(tributylstannyl)ethene undergoes Stille cross coupling with a variety of aryl, heteroaryl, vinyl and allyl organic electrophiles. …
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Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae
… In vitro assay studies demonstrate that tri- and difluoromethyl ketones can potentially inhibit An. gambiae AChE (AgAChE). These compounds inhibit the enzyme by making a covalent adduct with the catalytic serine of AChE. Trifluoromethyl ketones however are poor inhibitors of the G119S resistant …
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Development of decarboxylative strategies towards the synthesis of fluorinated pharmacons
… functional groups, such as trifluoromethyl ketones, difluoromethyl ketones, and trifluoroethanols, have emerged as desirable motifs in medicinal chemistry for the fine tuning of pharmacokinetic properties. Over the past few decades, fluoro(oxo) diversity has been accessed through oxidation …