Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"diffuse optical tomography (DOT)"”.
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Developing High-Density Diffuse Optical Tomography for Neuroimaging
… function. A decade ago, there was hope that optical imaging would be able to fill this role, as it combined fMRI's ability to construct cortical maps with EEG's portable, cap-based systems. However, early optical systems had poor imaging performance, and the momentum for the technique slowed. …
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Investigating Cerebral Function in Neonates Using Diffuse Optical Tomography
… detect and understand brain injury in patients. Diffuse optical tomography (DOT) is a promising imaging technique that is non-invasive, portable and relatively simple to operate. In this thesis, I describe the development and design of DOT headgear for neonates and subsequently apply this in …
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A multimodal breast cancer imaging system using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis
Diffuse optical tomography (DOT) is an emerging noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior …
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Purely optical tomography : atlas-based reconstruction of brain activation
Diffuse Optical Tomography (DOT) is a relatively new method used to image blood volume and oxygen saturation in vivo. Because of its relatively poor spatial resolution (typically no better than 1-2 cm), DOT is increasingly combined with other imaging techniques, such as MRI, fMRI and CT, which …
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Randomization for Efficient Nonlinear Parametric Inversion
… in science and engineering. We focus on diffuse optical tomography (DOT) in medical imaging. DOT aims to recover an unknown image of interest, such as the absorption coefficient in tissue to locate tumors in the body. Using a mathematical (forward) model to predict measurements given a …
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Development and Applications of Laminar Optical Tomography for In Vivo Imaging
Laminar optical tomography (LOT) is an optical imaging technique capable of making depth-resolved measurements of absorption and fluorescence contrast in scattering tissue. LOT was first demonstrated in 2004 by Hillman et al [1]. The technique combines a non-contact laser scanning geometry, similar …
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Retrieving Information from Scattered Photons in Medical Imaging
… in two specific medical imaging modalities: diffuse optical tomography (DOT) and single photon emission computed tomography (SPECT). To model the scattering of photons in biological tissue, we investigate using the Neumann-series form of the radiative transport equation (RTE). Since the …
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Study of the Term Neonatal Brain Injury with combined Diffuse Optical Tomography and Electroencephalography
This thesis describes the application of combined diffuse optical tomography (DOT) and electroencephalography (EEG) in the investigation of neonatal term brain injury. With hypoxic ischaemic encephalopathy (HIE) and perinatal stroke being the most frequent contributors to brain injury in the term …
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Robust Parameter Inversion Using Stochastic Estimates
… differential equations, such as those arising in Diffuse Optical Tomography (DOT), even the cost of repeated objective function evaluation can be overwhelming. Despite the linear (in the state variable) nature of the DOT problem, the nonlinear parameter inversion process is dominated by the …
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Investigating the protective role of heart rate variability on the effects of aging on cerebrovascular function as estimated by optical pulse parameters
… of the cerebral arterial pulse measured with diffuse optical tomography (pulse-DOT) following long and short inter-beat intervals (IBIs). Data were obtained from a sample of 141 normal individuals (age range 25-75 years), in which both EKG and pulse-DOT (measured from the entire cortical …