Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"diffuse axonal injury"”.
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Diffuse axonal injury effect on myelinating cells and axons
… evidence whether myelin degeneration in diffuse axonal injury (DAI) of the white matter is due to death of myelinating oligodendrocytes or secondary axotomy. Cortical neurons are not able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have …
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Comparison of progression of diffuse axonal injury with histology and diffusion tensor imaging
<p>Diffuse axonal injury, also known as traumatic axonal injury (TAI), is a major contributor to the pathology of traumatic brain injury. However, TAI is undetectable to conventional clinical magnetic resonance (MR) imaging techniques. Histologically, TAI is characterized by swollen axons that …
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Automated multi-well neural injury device
Traumatic Brain Injury (TBI) is a wide spread pathological problem occurring in 1.4 million individuals every year according to the National Institute of Neurological Disorders and Stroke. There are several types of TBI and the most prominent ones are concussion, contusion, hematoma, …
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Multi well uni-axial stretch injury device
Most diffuse brain injury is the result of uni-axial stretch of brain axons in traumatic brain injury. Traumatic injury to axons throughout the brain and is believed to be a major cause for coma, and other complications. Diffuse axonal injury is mostly multi-focal and appears throughout the deep …
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Mitochondria, Inflammation, and T-Cell Metabolism in a Rat Model of Pediatric Mild Traumatic Brain Injury
… in Canada every year, pediatric traumatic brain injury (TBI) can be an intractable medical problem with limited treatment options. While most research has been directed towards the devastating, moderate-severe end of the TBI spectrum, most clinical injuries present as mild with minimal duration …
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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, and Non-Specific Inflammatory Responses
A significant component of diffuse brain injury (DBI) is diffuse axonal injury (DAI) which is responsible for the morbidity and mortality associated with this condition. DAI and its experimental counterpart traumatic axonal injury (TAI) result in scattered microscopic pathology characterized by …
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Experimental Modelling and Molecular Mechanisms of Wallerian Degeneration in Traumatic Axonal Injury
Traumatic brain injury (TBI) is a common event that can lead to profound consequences for the individual involved, and a considerable socio-economic cost. The initial injury event triggers a series of secondary brain injury mechanisms that lead to further mortality and contribute to morbidity. One …
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Continuous Multi-Modal Monitoring of Cerebrovascular Reactivity in Adult Traumatic Brain Injury
… autoregulation following traumatic brain injury (TBI) in adults has been linked to worse global outcome. Continuously updating indices of cerebrovascular reactivity provide a convenient and continuous metric regarding an individual patients’ autoregulatory status. To date, the vast …
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Longitudinal Changes in Resting-State Connectivity after Traumatic Axonal Injury
… connectivity immediately after a traumatic axonal injury (TAI). This is the first longitudinal study in TAI to examine functional connectivity in the Default Mode Network (DMN) and Central Executive Network (CEN) within 48 hours after traumatic brain injury with repeat imaging 7 months …
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The characterization of the anterograde and retrograde consequences of traumatic axonal injury in a mouse model of diffuse brain injury
Traumatic axonal injury (TAI) is a consistent feature of (TBI) and is responsible for much of its associated morbidity. TAI is now recognized to result from progressive/secondary axonal injury, though much remains unknown in regards to the pathobiology and the long-term consequences of axonal …
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The Neurocognitive Sequelae of Chronic Traumatic Brain Injury and the Utility of Treatment with Methylphenidate
Traumatic Brain Injury (TBI) is a serious world-wide public health concern with a pressing need for adequate, effective long-term treatment. Cognitive deficits are a common complaint after TBI and persistent disabilities endure well into the chronic phases of the injury. Few recognised standard …