Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"differentiation proliferation"”.
-
Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
… plays a vital role in the regulation of lineage differentiation during development, as well as the maintenance of epithelial homeostasis in the intestine. KLF4 is predominantly expressed in the epithelial cells that are fully differentiated in normal intestine. In colorectal cancer, KLF4 was …
-
Structural Basis for Dishevelled-2 Association to the Plasma Membrane
… developmental pathways for control of cell differentiation, proliferation, and cell growth. The DEP domain, located on the C-terminus of Dishevelled (Dvl), plays a role in cytoplasm-membrane association, which branches the canonical and non-canonical Wnt signaling pathway within the cell. It …
-
Zinc Finger Protein 36L1 (ZFP36L1): Gene Expression, Regulation and Interactions with Immune Receptors in Human Tumour Cells.
… response factor 1 (BRF1) is involved in the differentiation, proliferation, and angiogenesis of various cell types. ZFP36L1 can positively or negatively regulate cellular processes such as transcription and signalling, depending on external and internal stimulations. The basic mechanism with …
-
The role of complex gangliosides in glial cell biology
… involved in numerous cellular events, including proliferation, differentiation, migration and neurite outgrowth. Gangliosides have also been shown to have neuroprotective actions and have been considered as candidates for the treatment of several neurodegenerative disorders. In this thesis, the …
-
Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System
… and has been shown to target key regulators of differentiation, proliferation and apoptosis. Here we identify a novel role for miR-184 in regulating the development and maintenance of the Drosophila melanogaster post-embryonic nervous system. We present evidence which suggest miR-184 targets (i) …
-
The Role of MICRORNAs on Systemic and Central Nervous System- Inflammation in Aged Mice
… processes, including development, cell differentiation, proliferation, metabolism, and cell death. Aberrant regulation of microRNAs is seen in many diseases, such as sepsis, cardiovascular disease, neurological diseases such as stroke, and metabolic disorders. Because of their …
-
FROM GENE TO STRUCTURE: Formation of Iduronic Acid in Dermatan Sulfate by Two DS-epimerases
… life a wide range of cell behaviors such as differentiation, proliferation and migration are in effect to maintain tissue integrity and function. An integral part of these dynamic processes is the interplay between the cells and their environment, i.e. the extracellular space. Complex …
-
Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
… of genes involved in inflammation, cell differentiation, proliferation, lipid and carbohydrate metabolism and energy homeostasis. The PPARs are potential targets for the treatment of dyslipidaemia, type II diabetes mellitus and the metabolic syndrome. This thesis uses a multi-platform …
-
Haploid reporter screens aimed at identification of NF-kappaB regulators
… in critical processes such as cell survival, differentiation, proliferation, and inflammation. Consequently, NF-KB activity must be tightly regulated and a failure to do so causes diseases such as inflammatory disorders and cancer. The identification of novel NF-KB regulators can increase our …
-
Manipulating soft materials to direct cell growth in multiple dimensions
… important biological differences, in their differentiation, proliferation rates, migration and cell signaling, in two- versus three-dimensional culture systems. Thus, there has been increased interest in the development of three-dimensional fabrication techniques to create microenvironments …
-
Mutational Analysis of CD127 and Its Role in Immunological Diseases
… non-redundant cytokine that influences T-cell differentiation, proliferation, homeostasis and T-cell functions. In T-cells, IL-7 signals are transduced via IL-7's heterodimeric receptor composed of a common, γ chain (CD132) and an IL-7 specific, α chain (CD127). In light of the many roles that …
-
Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… to previously known functions such as cell differentiation, proliferation, signal<br/>transduction, apoptosis and development. Additionally, several target-genes were<br/>identified, whose aberrant functions are associated with malignant transformation of<br/>cells, consistent with the …
-
Evolutionary analysis of animal microRNAs
… biological processes such as development, cell differentiation, proliferation and metabolism. The publication of the Human genome in 2001 marked the start of a great community effort to sequence a variety of other species. These data have great potential for comparative genomics, that can lead …
-
Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
… miRNAs function in cell fate determination, cell differentiation, proliferation and disease progression. Similar to transcription factors, which activate or repress a set of genes in a particular cell type, miRNAs create an environment, tailored for each cell type, allowing translation of some …
-
An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
… cellular signalling with effects on cell growth, differentiation, proliferation and apoptosis. These changes would explain the development of hepatic inflammation, apoptosis, fibrosis and malignant transformation seen in chronic HBV infection. Further investigation of these genes will provide new …
-
Optimizing Ex Vivo Culture of Satellite Cells
… understand mechanisms governing satellite cell proliferation and differentiation. We must also have tools that allow us to control these mechanisms. In this thesis, I tried to understand in vitro behavior of satellite cells and to find factors that can control their differentiation pathways. I …
-
Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
The differentiation of endometrial stromal cells to decidual cells, a process known as decidualization, is essential for the establishment of pregnancy. The decidual tissue produces multitude of factors that control a variety of physiological processes at the fetal-maternal interface, such as …
-
MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… with inflammation, immune activation, cell differentiation and hematopoiesis [94]. Most cytokines are pleiotropic and have multiple biologic activities that generally act over a short distance, during short periods of time and at low concentrations. They are produced and expressed by …