Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"differential susceptibility"”.
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The Social Environment, Genetics, and Obesity: Evaluation of Diathesis-Stress and Differential Susceptibility Frameworks
… (GxE) interaction: diathesis-stress and differential susceptibility. The diathesis-stress model has informed nearly all behavioral gene-by-environment studies and is the prevailing theoretical orientation among GxE scholars. Within the last decade, the differential susceptibility …
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Factors Related to Changes in Infant Attachment Security: A Test of the Differential Susceptibility Hypothesis
… stability outcomes. The newly developed differential susceptibility hypothesis posits that temperamentally difficult children are more influenced by their caregiving environment. In the present study, I examine infant irritability as a moderator of the link between changes in maternal (a) …
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Infant emotionality moderates relations between maternal parenting in early childhood and children's reactivity and effortful control at 54 months: Differential susceptibility or gene-environment dual risk vulnerability
… gene-environment dual risk vulnerability or differential susceptibility. Predicting later levels of childhood reactivity, infants with high levels of emotional intensity were more vulnerable to maternal rejection than infants with low levels of emotional intensity. Predicting later levels of …
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Exploring Interactions Between DRD4 Genotype and Perceived Parenting Environment
… of all variables. Both diathesis-stress and differential susceptibility hypotheses were assessed for examining possible interactions for children with the DRD4 7-repeat allele. Data were collected from 58 families within the Southern Illinois Twins/Triplets and Siblings Study (SITSS). Results …
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Genetic evaluation of cytochrome P450 expression in smoking and nonsmoking women
… of these isoforms may be responsible for the differential susceptibility to cancer in women.;2. Influence of menstrual phase and smoking status on expression of CYP1A1 and CYP1B1 in different regions of the uterus. The goal of this study was to investigate the expression of these isoforms in …
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Evaluating sleep and circadian rhythm disturbances and symptoms of impulsivity and inattention: Implications for adult attention-deficit/hyperactivity disorder
… the core molecular clock. However, we did find differential susceptibility to the previously identified risk factors; poor sleep quality and social jetlag which were both modified by genotype. Preliminary data from an exploratory study examining the neurophysiological correlates of response …
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Preventing guilt by association: Mindfulness and susceptibility to evaluative conditioning
… evidence suggests that individuals differ in susceptibility to EC and these differences may be related to various social and psychological biases. One variable that has been linked with less negative attitude formation, although not using an EC paradigm, is mindfulness. Further, mindfulness is …
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"Determining the Cause of Abnormal Leaf Development ""Leaf Tatters"" on White Oak (Quercus Alba L.), and Northern Red Oak (Quercus Rubra L.)"
… the growing season. In order to understand the differential susceptibility of white and red oaks in the landscape to leaf tatters, a comparative phenology study was conducted at multiple sites in Urbana. The red oak expanded leaf stage occurred earlier during the Julian calendar year than the …
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Stress Physiology and Behavior Problems
… in cortisol and sAA may indicate biological susceptibility to the effect of harsh discipline to develop both externalizing and internalizing problems among boys. Given the similar stress physiological patterns shown in Paper 1 and 2 for externalizing and internalizing problems, Paper 3 …
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QTL discovery for Japanese beetle resistance in aphid-resistant germplasm, stacking aphid-resistant genes, and metabolite profiling studies in soybean
… LD05-16060 (Uni. of Illinois) that showed lower susceptibility to Japanese beetle. A QTL (Quantitative Trait Loci) mapping approach with a subset of 94 individuals on 15 chromosomes indicated the presence of five QTL (QTL-M, QTL-G, QTL-H, QTL-D1b and QTL-E) previously reported to confer …
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The biology of crayfish plague (Aphanomyces Astaci: Schikora) in Great Britain
… effects demonstrated appeared to account for the differential susceptibility of the two species to Aph. astaci.
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Genome-Scale Quantification of Target Vulnerability in Mycobacterium Tuberculosis
… Additionally we created an approach to study differential vulnerability in clinical Mtb strains and under host-relevant growth conditions. We find that different biological pathways, while all essential for Mtb viability, vary widely in their vulnerability. We define highly vulnerable steps in …
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The role of host and microbial factors in the pathogenesis of chronic schistosomiasis in mice
… free environments (SPF1 and SPF2) and presenting differential susceptibility to chronic schistosomiasis. Our work revealed a higher susceptibility of C57BL/6 mice from the SPF2 facility in relation to C57BL/6 mice from the SPF1 facility. In confirmation with our first series of experiments, that …
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The Effects of Toluene on the Ontogenetic Development of the Fish, Oryzias latipes, the Japanese Medaka
… to the teratogenic action of toluene. The differential susceptibility of the embryos and fry was discussed in relation to the extent of cellular organization present at the time when first introduced in to the toluene solutions. The use of fish embryos in bioassays was discussed. Fish …
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Management of Potato Leafhopper and Maple Spider Mite on Nursery Grown Maples
… to <em>O. aceris</em> mortality Thus, differential susceptibility of these cultivars to spider mites is mediated by the capacity of leaf domatia to influence intraguild predation among phtyoseiid and stigmaeid predators. </em></p>
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Plasmodium falciparum protein kinase CK2
… amenable to inhibitor screening, and we report differential susceptibility between the human and P. falciparum CK2a enzymes to a small molecule inhibitor. Taken together, the data indicate that PfCK2a is an attractive, validated target for antimalarial chemotherapeutic intervention.
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Investigating the variation in susceptibility between Arabidopsis thaliana ecotypes in response to Botrytis cinerea infection
… to dissect the molecular basis of resistance (or susceptibility) to a given pathogen. In this study, the resistance of three Arabidopsis ecotypes (Col-0, RLD and No-0) to the necrotrophic fungal pathogen Botrytis cinerea was investigated using detached leaf infection assays, expression profiling …
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Insights into Neuroblastoma Initiation and Disease Progression Through integrative Genomics and Epigenomics
… to identify the causal germline SNP that drives differential susceptibility to neuroblastoma at the LMO1 oncogene locus. In Part 2, we use whole genome sequencing and Bayesian statistical modeling to understand the clonal evolution that occurs between diagnosis and relapse. Part 1: Neuroblastoma …
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An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
… of combinations: 1) biochemical synergism, 2) differential susceptibility of tumor cells to different agents, and 3) higher achievable dose intensity by exploiting non-overlapping toxicities to the host. Even if the toxicity profile of each agent of a given combination is known, the toxicity …
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Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
… the disease process, though the reasons for this differential susceptibility remain unclear. Understanding the mechanisms underlying the specific vulnerability of D2R-MSNs, or the resilience of D1R-MSNs, could guide strategies to delay neurodegeneration. In this study, we utilized an HD knock-in …
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