Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"differential protein expression"”.
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Differential Protein Expression and Butanol Production using <i>Clostridium beijerinckii</i>
… bacterial proteome in efforts to identifying key proteins that play role in the overall process of butanol fermentation. In the future we hope to genetically engineer microorganisms to efficiently carry out butanol fermentation at commercially significant levels. We were also able to find that the …
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Gel-based proteomic comparison of two strains of Propionibacterium freudenreichii ssp. shermanii
… of P. freudenreichii and detect inter-strain differential protein expression. The influence of a number of parameters on the quality of 2-D gels was also investigated. The pH 3-7 and pH 3-11 NL proteome maps obtained displayed 305 and 356 spots, respectively, and detected the differential …
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Quantitative Approaches for Protein Differential Expression Analysis
… protocols were developed to facilitate differential protein expression analysis and biomarker discovery via a two-step sample interrogation strategy: (a) global protein profiling and differential expression analysis by spectral counting; and, (b) biomarker candidate validation by …
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Differential expression profiling of proteomes of pathogenic and commensal strains of Staphylococcus aureus using SILAC
… by this pathogen. We proposed the variation in protein expression by commensal and pathogenic strain as an important factor behind the difference in pathogenicity. The identification of differentially expressed proteins was carried out using a quantitative mass spectrometry (MS)-based proteomic …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
… were performed using ductal ER+ tumours. Differential protein expression was compared between chemoresistant and chemosensitive samples using the Panorama XPRESS Profiler725 AbMA kit. The combined data from 9 AbMA assays and 3 2D-PAGE/MS experiments was then analysed using Ingenuity …
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Proteomic Map of ER+ Breast Cancer Cell Cycle
… mechanisms, molecular pathways and specific proteins involved in cell cycle progression in ER+ breast cancer cells. We focused on the G1-to-S phase transition of the cell cycle because major differences in cell proliferation mechanisms between normal and cancerous cells are observed at this …
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Identification of differentially expressed genes in AHI-1-mediated leukemic transformation in cutaneous t-cell lymphoma
… is demonstrated by gross perturbations in its expression in several leukemic cells lines, particularly in cutaneous T-cell lymphoma (CTCL) cell lines (Hut 78 and Hut 102). Hut 78 is derived from a patient with Sezary syndrome, a common leukemic variant of the human CTCL mycosis fungoides. …
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Proteomic investigation of blood-based biomarkers for the diagnosis of HIV-associated neurocognitive disorders
… of this panel to diagnosis of HAND. The differential protein expression profile of patients with and without HAND is thus compared. Aims and Objectives: The aim of this study was to assess the applicability of a set of Alzheimer's disease biomarkers to the diagnosis of HAND. In order to …
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Oncogene-induced reprogramming of heterotypic cellular interactions
… selection. The factors contributing to the differential fitness of particular mutations in various tissue contexts is poorly understood. I hypothesised that cells harbouring different KRAS oncogenic alleles produce altered secretomes, resulting in unique autocrine and paracrine effects that …
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Integrated cellular, proteomic and metabolite analysis of argyrin B with rational design approaches for immunoproteasome-selective inhibitors
… system plays a critical role in cellular protein degradation and homeostasis. Current proteasome inhibitors (PI) present great efficacy against haematologic cancers due to the high secretory load creating an increased dependency on proteostasis, yet resistance and adverse effects persist. …
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Analysis of Therapeutic Effect after Human Mesenchymal Stem Cell Transplantation in Ischemic Stroke Rat
… changes in free fatty acids (FFA) levels and proteins were detected in 4 days after MSC transplantation (Part 1, 2). I also evaluated the impact of the passage of MSCs on their effects in a rat stroke model (Part 3). Part I: Although ex vivo culture-expansion is necessary to use autologous …
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Application of Different Bioanalytical Workflows for Proteomics of Prostate Cancer
… application of optimized methods to analysis of differential protein expression to reveal molecular mechanism of drug action in animal model of prostate cancer. </p> <p>Characterization of the phosphoproteome in prostate cancer </p> <p>Our study in phosphoprotein signatures on a large scale in …