Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"differential dependency network"”.
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Differential Dependency Network and Data Integration for Detecting Network Rewiring and Biomarkers
… DNA copy number data. Genes work through complex networks to support cellular processes. Dysregulated genes can cause structural changes in biological networks, also known as network rewiring. Genes with a large number of rewired edges are more likely to be associated with functional alteration …
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Knowledge-fused Identification of Condition-specific Rewiring of Dependencies in Biological Networks
Gene network modeling is one of the major goals of systems biology research. Gene network modeling targets the middle layer of active biological systems that orchestrate the activities of genes and proteins. Gene network modeling can provide critical information to bridge the gap between causes and …
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Machine learning enabled bioinformatics tools for analysis of biologically diverse samples
… of signature genes and the analysis of differentially networked genes are two fundamental and critically important tasks. However, many current methodologies employ test statistics that don't align perfectly with the signature definition, potentially leading to the identification of …
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Modeling and Characterization of Dynamic Changes in Biological Systems from Multi-platform Genomic Data
… cellular activities at the individual gene and network levels. The aim of this dissertation is to formulate mathematically dynamic changes in biological networks and DNA copy numbers, to develop machine learning algorithms to learn these statistical models from high-throughput biological data, …