Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"diethylnitrosamine"”.
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Determination of volatile nitrosamines in foods and other environmental samples
… of added dimethylnitrosamine and 110% of added diethylnitrosamine were recovered from 10 ng/g spiked aqueous solutions. The factors affecting recovery of these nitrosamines were investigated. The usefulness of Freon-11 as an extracting solvent for nitrosamines was investigated using both batch …
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DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS
… levels of environmental chemicals, benzene and diethylnitrosamine, and chemotherapeutic agents, etoposide and doxorubicin, generate significant DNA breakage within RET at levels similar to those generated by laboratory fragile site-inducing chemicals. These results suggest the role of long-term …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… to the tobacco carcinogens: urethane and diethylnitrosamine. Importantly the resulting cell lines (n = 7) were immortal and phenotypically stable in vitro, oncogenic, metastatic and lethal in vivo. Moreover, these cells exhibited marked similarity with the human lung adenocarcinoma, …
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The pathological and genomic impact of CTCF depletion in mammalian model systems
… mouse model of Ctcf hemizygosity with diethylnitrosamine-induced liver tumours. Ctcf hemizygous mice had a subtle liver-specific phenotype, although the overall tumour burden in Ctcf hemizygous and wild-type mice was the same. Using whole genome sequencing, the highly reproducible …
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Dietary broccoli impedes Western diet-enhanced fatty liver and hepatocellular carcinoma development
… intervention. A combined Western diet-fed and diethylnitrosamine (DEN)-treated mouse liver cancer models was used in order to evaluate the changes in hepatic lipidosis, macrophage activation, and tumorigenesis after long-term consumption of broccoli. Our results show that dietary broccoli …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… colon cancer-derived liver metastasis and diethylnitrosamine (DEN)-induced hepatocellular carcinoma. The number and dimension of liver and lung metastasis and the liver disease severity were significantly reduced in Il1r8<sup>-/-</sup> mice. The depletion of NK cells in these models totally …
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Identifying unique cell states in early liver oncogenesis with transcription coupled repair
… predispose hepatocytes to tumorigenesis in the diethylnitrosamine (DEN) mouse model of HCC using a novel method of transcriptomic profiling. DEN introduces adducts onto DNA that lead to mutations, and the principal adduct on thymine can only be removed by the DNA repair process transcription …
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Role of Hydroxy acid oxidase 2 (Hao2) in hepatocellular carcinoma
… with a single dose of the hepatocarcinogen Diethylnitrosamine (DENA). Next, we investigated whether Hao2 down-regulation is an early event during liver carcinogenesis; to this aim, we analyzed the expression of Hao2 by qRT-PCR in preneoplastic lesions and HCCs generated 10 weeks, and 14 …
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Investigations on the antifungal and cancer modulating properties of extracts from selected species of Tulbaghia
… material of F. verticil/ioides MRC 826 utilizing diethylnitrosamine (DEN) as cancer initiator. Clinical chemical parameters related to liver and kidney function and decreased body weight gain suggesting that severe, acute liver injury had been induced in the positive control (DEN-eMF) rats, while …
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Cell senescence and aging in carcinogenesis and liver repopulation
… by RS. Animals given the genotoxic agent diethylnitrosamine (DENA) followed by RS developed large hepatocyte nodules within a few months. However, the growth of preneoplastic nodules was significantly delayed in animals receiving hepatocyte transplantation following the DENA+RS regimen. …
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Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro
… to DNA and ultimately lead to carcinogenesis. Diethylnitrosamine (DEN) is one of the most important environmental carcinogens, present in a variety of foods, alcoholic beverages, tobacco smoke and it can be synthesized endogenously. In addition to the liver it can induce carcinogenesis in other …
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The Contribution of Environmental Cues to Early Squamous Tumour Formation in the Upper Gastrointestinal Tract
Recent studies have revealed that normal epithelium in various tissue types harbour substantial populations of mutant clones similar to those found in cancer. This implies that the accumulation of somatic mutations alone may not be the sole cause of cancer and that other factors are required. …