Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"diet-induced obesity"”.
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Orexin Signaling and the Prevention of Diet-Induced Obesity
… deficiency in humans and mice is associated with obesity. Prolonged effects of orexin signaling upon energy homeostasis have not been fully characterized. In this study, I utilized both genetic and pharmacologic approaches to characterize metabolic effects of orexin gain of function. CAG/orexin …
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Low-grade aldehyde stress protects mice from diet-induced obesity
… endogenous aldehyde stress are resistant to obesity and onset diabetes induced by high glucose and fat dietary challenges. This protection is mediated by GDF15, a hormone that is elevated in response to endogenous formaldehyde stress when DNA repair is intact and causes a decrease in food …
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Role of Lipolysis and Lipogenesis in the Development of Diet-Induced Obesity
<p>Obesity is an increasingly common public health problem with approximately one-half of the American adult population overweight and one-quarter considered obese. This alarming trend has led researchers to determine potential causative factors of excess weight gain in humans. However, it is …
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The impact of diet-induced obesity and exercise on adipose-resident stem cells
… C57BL/6J mice were placed on control or high fat diet (HFD) for 8 wk prior to and following initiation of a 16 wk treadmill exercise program. ADSCs (Sca-1+CD45-) were isolated from epididymal adipose tissue and mRNA was evaluated using high throughput qPCR. While resulting in a total increase in …
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SEC16B modulates high fat diet induced obesity in female but not male mice
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Diet-induced-obesity suppresses beta-catenin and promotes cell proliferation during colon development
The student, Guanying Xu, submitted this Thesis for approval on 2018-07-17 at 11:44.
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The oligodendrocyte lineage of the median eminence in the adaptation to diet-induced obesity
… and myelin accumulate in the ME during diet-induced obesity (DIO). The work presented in this thesis further characterises ME oligodendrocyte lineage cell physiology in DIO mice and demonstrates that changes in oligodendrocyte lineage cell plasticity occur in response to subacute …
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Viral Delivery of the Fat-1 Gene to Treat Post-Traumatic Arthritis with Diet-Induced Obesity
… to knee replacement; however, in the presence of obesity, the levels of pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α,) are more elevated than in non-obese individuals. The role of fatty acids, obesity, and PTA has been examined, with omega-3 fatty …
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Role Of The Alzheimer's Amyloid Precursor Protein In High Fat Diet Induced Obesity And Regulating Macrophage Phenotype
… Based upon the fact that midlife obesity is a risk factor for Alzheimer's disease and both obese adipose tissue and Alzheimer's disease brains share a common presence of increased, reactive macrophage and microglia, respectively, we hypothesized that APP may have a common role in …
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Prenatal and postnatal nutritional influences on leptin sensitivity and susceptibility to diet-induced obesity in the rat
… can determine an individual’s susceptibility to obesity in adult life. However, the specific causal mechanisms which underlie this hypothesis have yet to be identified. Focusing on the potential mechanistic role of the leptin endocrine axis, the main objective of this thesis was to investigate …
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Benefits of Quercetin on Metabolic and Inflammatory Biomarkers in High Fat Diet Induced Obesity: A Dose Response Study
<p>Obesity is a chronic low-grade inflammatory disease that can lead to a variety of health complications including coronary heart disease, type 2 diabetes, hypertension, degenerative diseases and a wide array of cancers. For this reason, dietary supplements with anti-inflammatory properties have …
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Chickpea (Cicer arietinum) protein hydrolysate ameliorates the metabolic effect of feeding a high-fat-diet-induced obesity in mice by modulating inflammation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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THE METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING
… University Carbondale. THE METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING MAJOR PROFESSOR: Dr. Andrzej Bartke It is well established that high calorie diets providing mostly fat and simple …
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Pharmacological Investigation with Anethole in an Experimental Model of Obesity // Фармакологични проучвания с анетол в експериментален модел на затлъстяване
… orally in increasing doses to rats in a model of obesity induced by a high-calorie diet. For this purpose, 50 male Wistar rats, divided into 5 groups, consumed a high-calorie diet and were treated with three different doses of anethole for 10 weeks (65, 125 and 250 ml/kg). Behavioural, …
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The role of Arginyltransferase 1 in body weight homeostasis
… results in dramatic fat loss and resistance to diet-induced obesity. However, the mechanisms through which ATE1 influence energy metabolism remain unclear. Here, we investigated the hypothalamic role of ATE1 by examining the effects of the anorectic hormone leptin in wild type (WT) and …
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
… leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo model.
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The early origins of obesity: the importance of prenatal vs postnatal environment.
There is growing evidence that maternal obesity, maternal hyperglycemia or maternal intake of diets high in fat, sugar or total calories during pregnancy and lactation is associated with an increased risk of obesity and metabolic diseases in the offspring. The majority of studies to date, however, …
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The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of obesity by CL 316,243, a new beta3-adrenergic agonist.
Obesity is a prevalent health hazard that is associated with other metabolic disorders, in particular with insulin resistance and non-insulin-dependent diabetes mellitus. Treatment of obesity requires an increase in energy expenditure or a decrease in energy intake or both of these. One target for …
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Novel Roles of the Aryl Hydrocarbon Receptor in Normal Physiology and Epigenetic Reprogramming
… been reported to confer resistance to western diet induced obesity as well as reversing diet induced obesity. Together, these observations suggest a direct role for AhR regulating normal metabolic homeostasis and implicate AhR as a potential therapeutic target for obesity. However, much of the …
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