Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"dicentric"”.
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Centromere identification and inactivation on a neo-Y chromosome fusion in threespine stickleback fish (Gasterosteus aculeatus)
… meiosis. Chromosomes containing two centromeres (dicentric) often mis-segregate during cell division, resulting in aneuploidy or chromosome breakage. Dicentric chromosomes can be stabilized by centromere inactivation, a process which re-establishes monocentric chromosomes. There are two proposed …
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Repetitive Sequences Drive Rapid Adaptation in Candida albicans
… repeat sequences, leading to the formation of a dicentric chromosome. The copy number of these CNVs is rapidly expandable in the presence of antifungal drug, due to successive rounds of the breakage-fusion-bridge cycle and homologous repair. Importantly, we describe how removal from antifungal …
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Variation in chromosomal aberration induction in differing ATM and ASPM genotypic backgrounds detected via a modified PNA FISH technique
… elevations in acentric fragment and/or dicentric average frequencies seen across all strain backgrounds of the Atm-/- genotype, however, only the 129S6 Atm-/- strain backgrounds exhibited a significant increase in mean telomere-associated fusion events. In addition, there was a …
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Neotelomere Formation by Telomerase in Human Cells
… repeated breakage-fusion-bridge cycles, forming dicentric chromosomes that snap during mitosis. Ultimately, clinically detectable tumors emerge from this process with shuffled, aneuploid genomes after acquiring a telomere maintenance mechanism, usually by reactivating TERT expression. …