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Showing 1 to 11 of 11 for “"diboron reagent"”.
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The development and applications of unsymmetrical diboron compounds
… of the previous examples employed symmetrical diboron reagents such as B₂(pin)₂ (pin = pinacolate) and B₂(cat)₂ (cat = catecholate). There are, however, limited examples of boration using unsymmetrical diboron reagents. This dissertation discloses two transition metal-catalyzed borations of …
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Development of Novel, Regioselective Borylation Protocols
… involving substrate-mediated activation of a diboron reagent. This dissertation describes the author's contributions to the development of both a transition metal-catalyzed diboration and a transition metal-free protoboration. A transition metal-free diboration of alkynamides is described in …
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Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents
… metal-catalyzed protocols to incorporate boron reagents into unsaturated compounds have been extensively researched. While an abundance of literature protocols have been reported, the majority utilize harsh reaction conditions in combination with expensive reagents. This dissertation discloses …
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Selective Borylations of Carbon-Carbon pi-Bonds
… that exemplifies the capability of organoboron reagents is the Suzuki-Miyaura cross-coupling reaction, which is used to generate carbon-carbon bonds under mild conditions. Because of the versatility of organoboron reagents, methods to selectively install boron remains crucial. Boron containing …
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Synthetic and catalytic studies of Group 11 N-heterocyclic carbene complexes
… of the borate complex with the bis(pinacolato)diboron, (pin)B-B(pin), giving the stable byproduct (pin)B-O-B(pin). The use of a copper(I) alkoxide precatalyst and stoichiometric diboron reagent results in catalytic reduction of CO2, with high turnover numbers (1000 per Cu) and frequencies (100 …
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Regio- and Stereo- selective Methods for the Borylation of Substituted Alkynes
… of tri-n-butylphosphie and the unsymmetric diboron reagent pinBBdan, 1-boryl-1,3-enyne products were generated in up to 63% and >99:1 (Z)-selectivity. These 1,8-diaminonaphthalene products can be converted to the corresponding pinacolboranes or trifluoroborate salts. They also demonstrated …
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Boron-Mediated Semireduction of Alkynoic Acid Derivatives
… remain important for designing new drugs. Boron reagents are also useful in chemical transformations that do not ultimately install a boron moiety on the organic molecule. We have developed several methods that achieve the trans-selective borylation or semireduction of internal alkynes, a process …
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Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds
… allenes with a differentially protected diboron reagent, pinB-Bdan. The reaction proceeds regioselectively in high yields to furnish olefins bearing a vinylic Bpin and an allylic Bdan moiety. The subsequent chemoselective transformation of each boron center was demonstrated. Methods for …
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Development of Methods for Boron Reagents
Boron reagents are known to be valuable in the field of organic chemistry due to their abilities to undergo a variety of transformations, resulting in useful pharmaceuticals and synthetic intermediates. It has also been shown that diboron reagents can act as reaction mediators due to the unique …
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds
… using transition metal-catalyzed reactions of diboron reagents. A unique "mixed" diboron reagent was developed (PDIPA diboron) that contains sp2- and sp3-hybridized boron atoms, unambiguously confirmed by X-ray crystallography. PDIPA diboron is sufficiently activated internally through a …
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Iridium-catalyzed borylation of aromatic and aliphatic C-H bonds: methodology and mechanism
… ancillary ligands. In addition, other boron reagents besides the common bis(piacolato)diboron were studied in the C-H borylation of arenes. A different diboron reagent, bis(hexyleneglycol)diboron, reacts with arenes to form arylboronate esters in good yields. The borylation of secondary C-H …