Global ETD Search
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Showing 1 to 4 of 4 for “"diazotransfer"”.
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Modularer Ansatz zu multifunktionellen Polymer-Peptid-Fasern
… auf die Polymer-Peptid-Fasern übertragen. Der Diazotransfer stellte dabei die Methode der Wahl dar, so können Azidgruppen aus Aminen gewonnen werden. Unter Verwendung der 1,3-dipolaren Addition konnten verschiedene alkinfunktionale Moleküle kovalent an die azidfunktionalisierten …
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Synthesis and Grafting To of Biomimetic Bottlebrush Polymers
… azide-alkyne cycloaddition and newly discovered diazotransfer reagents. I demonstrated the effectiveness of this synthetic path at each step through careful characterization with 1H-NMR, FTIR, GPC, and diagnostic test reactions on SDS-PAGE. In the second half of this work, I determine the …
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TEMPLATE DIRECTED C-H INSERTION REACTIONS FOR STEREOCONTROLLED SYNTHESIS OF HETEROCYCLES
… from the aldehyde acetals in 3 steps involving diazotransfer onto the vinylketones prepared by oxidation of the allylalcohols which resulted from treating the aldehyde acetals with allylmagnesium bromide. Good yields of products were achieved in all 3 steps. The aldehyde acetals were synthesised …
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Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides
In the scope of our BACE1 inhibitor project we used an originally designed microtiter plate-based screening to discover 4 triazole-linked reduced amide isosteres that showed modest (single digit micromolar) BACE1 inhibition. Our ligands were designed based on a very potent (single digit nanomolar) …