Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"diazepam"”.
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Analytical studies on diazepam
… developed which are specific for the analysis of diazepam in the presence of formulation excipients, closely related degradation products and manufacturing impurities. The methods developed used difference ultraviolet spectrophotometry and HPLC. These methods have been applied to the analysis of …
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IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
… using numerical methods and ODEs. The model drug diazepam (DZP) was chosen as the probe substrate to demonstrate complex CYP kinetics with specific CYP enzyme sources, including rat liver microsome (RLM), human liver microsome (HLM), purified CYP enzyme isoforms and rat hepatocytes. All saturation …
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The Photodegradation of Diazepam and its Human Metabolites in Water
… In the present study, the anti-anxiety drug, diazepam (Valium®) along with its known human metabolites, nordiazepam, temazepam and oxazepam were selected for photodegradation studies. The photodegradability of each drug in distilled and natural waters was evaluated using a Suntest CPS Xenon …
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Influência clínica e tecidual do diazepam no periodonto de sustentação durante o movimento ortodôntico
There were evaluated the effect of diazepam, a potent inhibitor of the cyclic AMP (cAMP) hydrolysis, on the tissue reactions related to orthodontic tooth movement. There is evidence suggesting that cAMP plays an important role as intracellular mediator of bone remodeling induced by mechanical …
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Diazepam administration during acute thiamine deficiency attenuates subsequent neuropathology and spatial-memory deficits in rats
… rats received PTD treatment; one group received diazepam (5mg/kg) upon the first sign of overt seizures in order to attenuate them until treatment reversal (Group PTD+DZ), and the other group received no diazepam (Group PTD). Following recovery, the rats were trained on a delayed …
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Post-Juvenile Brain Development Modulates Seizure Characteristics and Diazepam Efficacy in the Rat Pilocarpine-SE Model
… ages. The third study displayed modulation of diazepam efficacy during post-juvenile ages. The data suggest characteristics in the acute discrete seizure pliase, chronic SE phase, and therapeutic window of SE change in relation to age during post-juvenile brain development. This establishes …
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Modulation of hippocampal synaptic transmission by the peptide diazepam binding inhibitor and optogenetic manipulation of astrocytes
… signaling molecules and cell types. The peptide diazepam binding inhibitor (DBI) has complex physiological functions and is capable of both enhancing and attenuating inhibitory synaptic transmission in different brain regions. However, whether DBI modulates hippocampal synaptic transmission or …
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Some Effects of the Acute Use of Diazepam Alone and in Combination With Alcohol, on Driving Performance
Made available in DSpace on 2014-12-14T06:57:28Z (GMT). No. of bitstreams: 1 7915365.pdf: 4203494 bytes, checksum: bb454e4de05c77695e7ee430aaefad08 (MD5) Previous issue date: 1979
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Mind games: The effects of diazepam on Evoked Potentials. Part A: passive paradigms; Part B: EEG-EP interrelations
Contains fulltext : 18868_mindga.pdf (Publisher’s version ) (Open Access)
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EFFECTS OF DIAZEPAM, D-AMPHETAMINE, AND MORPHINE ON RATS’ CHOICES BETWEEN FOOD ALONE AND FOOD WITH DELAYED SHOCK
… The present study evaluated acute effects of diazepam, <em>d</em>-amphetamine, and morphine on rats’ choices using a variable-delay procedure that arranged choices involving conflicting-valence consequences. Rats pressed response levers to choose between a single-valence consequence (1 food …
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Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
… cross-tolerance, and withdrawal of zolpidem and diazepam in C57/BL6J mice after different treatment durations. Elucidating the mechanisms behind zolpidem tolerance and withdrawal is necessary due to the ongoing usage of subunit specific GABAAR PAMs and, to a broader extent, an understanding of …
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Pharmakologische Magnetresonanztomographie des Gehirns der Ratte bei hoher magnetischer Feldstärke
… hervorgegangen sind. Das Benzodiazepin Diazepam wirkt bei HAB-Ratten wesentlich stärker anxiolytisch als bei LAB-Ratten. Man kann daraus folgern, daß Diazepam differentiell auf Hirnregionen wirken muß, die Angstverhalten steuern. In umgekehrter Logik sollte eine Region, für die gezeigt …
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Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines
… used being intravenous lorazepam or rectal diazepam. Despite the effectiveness of these drugs, the delivery routes are not ideal for first-line, outpatient treatments. A skilled caregiver must be present to administer drugs intravenously, and the social stigma associated with rectal …
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The chemical and physical characterisation of illicit tablets and development of a statistical model to identify populations within the illegal supply chain
Diazepam is an effective pharmaceutical used for both medicinal and illicit purposes and its popularity has led to the sale of both diverted pharmaceutical tablets and illicitly manufactured products. The aim of this project was to characterise 65 different cases of illicit tablets seized from the …
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Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus
… anticonvulsant efficacy of the benzodiazepine, diazepam. Firstly, I confirm that benzodiazepine-resistant SE is prevalent in a South African paediatric population. Secondly, consistent with its established mechanism of action, I show that diazepam enhances GABAAR synaptic currents. Thirdly, …
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Robust Processes for Polymer Modification and Pharmaceutical Synthesis
… medication. Chapter 4: Progress Towards a Diazepam Precursor for Telescoped Flow Synthesis Diazepam (Valium®) is an important medication for the treatment of various central nervous system symptoms and disorders. On-demand flow synthesis of this molecule presents many benefits, but …
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Liquid Chromatography -- Tandem Mass Spectrometry Techniques for Drugs of Abuse as Applied to Bacterial and Forensic Toxicology
… mass spectrometry method was developed for diazepam, flunitrazepam, and metabolites in Reinforced Clostridial Medium. Reinforced Clostridial Medium is a complex matrix designed to provide the nutrients necessary to promote growth of bacterial species, particularly Clostridia, other …
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The reduction of tolerance to the anticonvulsant effects of antiepileptic drugs
… of tolerance to the anticonvulsant effects of diazepam. As in Experiment 1, amygdala-kindled rats were exposed to either a high-dose regimen (10.0 mg/kg), a low-dose regimen (1.0 mg/kg), an ascending-dose regimen (from 1.0 to 3.0 mg/kg), or the saline vehicle during the tolerance-development …
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Fate and behaviour of drugs in the environment
… and morphine and a pharmaceutical (diazepam) was based on their presence in the STW effluent. The results obtained using solid phase extraction gas-chromatography technique (SPE-GCMS) showed thirteen compounds detected at concentrations between 1.9 and 3147 ng L-1 in effluents from …
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