Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"dialysis-related amyloidosis"”.
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High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis
Proteinaggregation ist die Ursache vieler Krankheiten, wie Diabetes Mellitus Typ 2, Parkinsonsche, Alzheimersche und Huntingtonsche Krankheit, spongiforme Encephalopathien, Stauungsinsuffizienz und Dialyse-assoziierte Amyloidose. All diesen Störungen liegt eine Proteinfehlfaltung zugrunde, die zur …
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A fluidized immunoadsorption device for removing beta-2-microglobulin from whole blood : a potential treatment for dialysis-related amyloidosis
Dialysis-related amyloidosis (DRA) is a frequent complication of end-stage renal disease that has been associated with the accumulation of 2-microglobulin (2m). Excluding transplantation, existing kidney replacement technologies are believed to remove insufficient quantities of P2m for the …
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β2-mikroglobulino gryninimas ir skysčio-skysčio fazių atsiskyrimo tyrimai /
… the formation of amyloid fibrils and can lead to dialysis-related amyloidosis. A rapidly growing area of research is liquid-liquid phase separation (LLPS), the process by which proteins and other biomolecules separate from the bulk solution to form dense, membraneless condensates. Although dozens …
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Amyloid fibril structure of peptides and proteins by magic angle spinning NMR spectroscopy and dynamic nuclear polarization
… - an 11- residue segment from the disease-related protein transthyretin (TTR); and P2- microglobulin (32m), a 99-residue protein associated with dialysis-related amyloidosis. The TTR(105-115) case exemplifies our efforts to characterize the hierarchy of structures present in the fibril …
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An investigation into the effects of inorganic element status on the accumulation and deposition of amyloid in various diseases.
… disease and β2 microglobulin (β2M) deposition in dialysis related amyloidosis. The major factor for amyloidosis appears to be an increase in the production of amyloidogenic proteins, resulting in the amyloid β sheet deposits. It is clear that conformational changes in amyloidogenic proteins lead …
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THE LYSOSOMAL AMYLOID AGGREGATION OF B2-MICROGLOBULIN PROMOTES MULTIPLE MYELOMA PROGRESSION: A MOLECULAR FOCUS ON THIS PRO-CANCER MECHANISM
… whose aggregation into amyloid fibrils underlies dialysis-related amyloidosis. Beyond this role, β2m also serves as prognostic factor for several hematological malignancies, including multiple myeloma (MM). Recent studies demonstrated that β2m actively contributes to MM pathogenesis by aggregating …
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Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
… (AD) and Parkinson's disease (PD) and dialysis-related amyloidosis. AGE-modified proteins are also involved in the complications of diabetes. AGEs accumulate in the the ß-amyloid plaques and neurofibrillary tangles (NFT) associated with AD and in the Lewy bodies characteristic of PD. …