Global ETD Search
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Showing 1 to 17 of 17 for “"dialdehyde"”.
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Chemical Studies on Nucleic Acid Analogues
… modification with both glyoxal (an (alpha)-dialdehyde) and methylmalondialdehyde (a (beta)-dialdehyde) from a common precursor in four and eight steps, respectively, using a sequence which allows us to distinguish between the two potential structural isomers. For each product, open-ring …
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Development of a New General Click Chemistry and Applications in Bioconjugation: Part I: Rewiring Bacteria Cell Surfaces with Bio-Orthogonal Chemistry Part II: A Novel General Dialdehyde Click Chemistry for Primary Amine Conjugation
… trapping of amine groups via a functionalized dialdehyde group. The click reaction occurs in mild conditions in organic solvents or aqueous media, proceeds in high yield. Moreover, no catalyst or activating group is required and the only by-product is water. The dialdehyde headgroup was used …
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The Development of Gelatin Based Tissue Adhesives for Use in Soft Tissue Biomedical Applications
… and adhesive properties of Gelatin Resorcinol Dialdehyde (GR-DIAL) tissue adhesives by varying formulation. Three adhesive formulations with altered weight content of water and glyoxal (a dialdehyde) were utilized. The adhesive formulations were characterized by pH and gelation time in situ, …
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Towards the Design and Syntheses of Novel Triads Comprising Single Robson-Type Macrocyclic Dicopper(II) Cores Flanked by Two Terminal Polypyridyl Ruthenium(II) Complexes.
… zinc tetrafluoroborate and the same diamine and dialdehyde. The new dicopper(II) complex did not heterocouple with borylated substrates under explored Suzuki reaction conditions. 5-Bromo-2-(methoxymethoxy)benzene-1,3-dicarboxaldehyde successfully heterocoupled with …
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Triphenylene as a Scaffold for New Molecular Materials
… triphenylene. The formation of the triphenylene dialdehyde had previously eluded our group, however following a new protocol gave a successful synthesis. There were a number of potential compounds to investigate from this versatile precursor. We chose to target BODIPY-triphenylene hybrid …
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Stereoselective synthesis of all-C quaternary stereocentres using non-enolisable 1,3-dialdehydes
… been carried out into using non-enolisable 1,3-dialdehydes, under MgBr2•OEt2 chelation control, as small building blocks for the synthesis of all-C quaternary centre as part of a stereoarray. Initial investigations focussed on developing controlled monoadditions to non-enolisable dialdehydes …
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Thiopyran route to polypropionates : simultaneous-two directional and enantiotopic group selective aldol reactions
… Section 2.4 discusses the preparation of a meso dialdehyde derivative of thiopyranone (196) and it’s use in a simultaneouse two directional aldol reaction to generate a hexapropionate building block with six stereocenters in a one pot reaction. The meso adduct 202as generated was successfully …
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Benign Catalysis and Expansion of Cyclobenzoins
… that the general poor solubility of the aromatic dialdehyde materials in the aqueous conditions prevented their use as cyclobenzoin precursors. Leveraging the newly developed N-heterocyclic carbenes, particularly the ability to utilize organic solvents, two completely novel cyclobenzoins were …
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Studies on the Methylcoenzyme M Methylreductase System of Methanobacterium Thermoautotrophicum
… of the system by ATP. The utilization of the dialdehyde of ATP showed that component A3 was also involved in this activation. When various sources of electrons were used, it was shown that the methylreductase system had two separate requirements for reducing equivalents, one of them to …
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Three-Way Chemoselectivity Switching through Coupled Equilibria in Complex System and Post-synthetic Modification of Cyclobenzoins
… has been expanded by using various types of dialdehyde, which increase the size of the central core of cyclobenzoin. Chapter Four, the new autocatalytic cycle based on diaza-Cope rearrangement, is illustrated. However, it has not been successful yet, but it inspired the synthesis of three new …
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THE SYNTHESIS AND CHARACTERIZATION OF DUAL-MODIFIED CARBOXYMETHYLCELLULOSE FOR BIOADHESIVE APPLICATIONS
… weight and medium molecular weight methacrylated dialdehyde carboxymethylcellulose (MeDCMCHV & MeDCMCMV) were engineered and MeDCMCHV was combined with low viscosity methacrylated CMC (MeCMCLV1) to produce an adhesive hydrogel. The percent oxidation and methacrylation was measured to be 21.1 ± .84 …
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New applications for surfactant based colloidal systems: an experimental and computational approach
… product, while CTAB micelles give both mono and dialdehyde as the product. In order to understand the differences in the oxidation of diol in CPB and CTAB micelle, molecular dynamics (MD) simulations have been performed using GROMACS package (Chapter 3). A united atom force field for CPB molecule …
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Synthesis and applications of aminated biopolymers
… periodate oxidation of cellulose provided dialdehyde cellulose (DAC) ready for reductive amination. The synthesised diamino and amino celluloses were DMSO-soluble and were tested for cytotoxicity against brain cancer cell lines. Cytotoxicity studies showed that the aminated celluloses did …
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Multicomponent Diels-Alder Sequences of 1-Aminodendralenes
… polycyclic products. By using a diene-dialdehyde as the starting precursor, it is anticipated that the Horeau principle would operate in the twofold condensation/Diels-Alder/elimination reaction sequence would furnish the cycloadduct in high enantioselectivity. A preliminary attempt …
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Multicomponent Diels-Alder Sequences of 1-Aminodendralenes
… polycyclic products. By using a diene-dialdehyde as the starting precursor, it is anticipated that the Horeau principle would operate in the twofold condensation/Diels-Alder/elimination reaction sequence would furnish the cycloadduct in high enantioselectivity. A preliminary attempt …
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Tripodale Metallkomplexe und Makrocyclen von Triphenylamin-Derivaten
… 2,2’,2’’-Nitrilotriphenylamin und verschiedenen Dialdehyden konnten sechs Makrocyclen L4 - L9 hergestellt werden. Durch Variation der Spacer (Dialdehyde und Diamine) können die Größe der Makrocyclen und damit ihre Koordinationseigenschaften gesteuert werden. Auffällig war dabei das …
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Iron nanoparticles and zirconium metal-organic frameworks for therapeutic application
… of the cluster via the introduction of a dialdehyde. This allowed the interconnection of discrete clusters to form an inorganic polymer. In Chapter 7, further avenues for research are discussed. These build on the ideas developed in this thesis and highlight where immediate work efforts …