Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"diagnostic biomarker"”.
-
Quantitative Oil Source-Fingerprinting Techniques and Their Application to Differentiating Crude Oil in Coastal Marsh Sediments
… to test two different quantitative techniques: diagnostic biomarker ratio analysis and chemometrics. The most common crude oil constituents used for oil source-fingerprinting are the oil biomarker compounds. Oil biomarkers are polycyclic aliphatic hydrocarbon molecules typically resistant to …
-
The Use of Ischemia-modified Albumin(IMA) in Ischemic Stroke
… albumin (IMA) as a new and rapid diagnostic biomarker of ischemic stroke and compare IMA in progression of stroke and non-progression of ischemic stroke. METHODS: Fifty-two emergency patients with acute neurologic symptoms were admitted to the emergency department within 6 hours of …
-
TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
… findings unmasked the potential of TSPAN8 as a diagnostic biomarker and therapeutic target in liver cancer and provided novel insights into its molecular regulation.
-
Functional genomics of developmental disorders
… I characterise DNA methylation signatures as a diagnostic biomarker for children with rare developmental disorders in chromatin-modifying genes. I show that DNA methylation signatures are a general property of these genes, that they have substantial clinical and diagnostic utility, and that they …
-
Multiresolution wavelet analysis of event-related EEG potentials using ensemble of classifier data fusion techniques for early diagnosis of Alzheimer's disease
… its more severe stages due to lack of standard diagnostic tools available to community clinics. A search for biomarkers that will allow early diagnosis of the disease is therefore necessary to develop effective medical treatments. Such a biomarker should be non-invasive, simple to obtain, safe, …
-
MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Approaches For Better Diagnosis And Therapy
… lack of disease-specific symptoms and reliable diagnostic biomarkers. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) and surgery has become the standard of care for patients with PDAC. Carbohydrate antigen 19-9 (CA 19-9) is the most common diagnostic biomarker; …
-
Translating biomedical research data to knowledge through bioinformatics
… be particularly useful for identifying novel diagnostic biomarker panels. Furthermore, we assessed two different intervention strategies for schistosomiasis using the meta-analysis method and demonstrated that implementation of the new integrated strategy reduces the infection risk by ~3–4 …
-
Medicina de precisión: ncRNAs como herramienta diagnóstica para pacientes con intolerancia a estatinas de alto y muy alto riesgo cardiovascular
… consider it a priority need to identify biomarkers with discriminatory accuracy for a true diagnosis of statin intolerance (SI) in these patients. MicroRNAs (miRNAs) have emerged in recent years as molecules that offer valid biomarker roles involved in the regulation of multiple cellular …
-
Near Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therapy
… to assist in the development of ChoKa as a diagnostic biomarker and therapeutic target. A series of compounds were synthesized for this purpose, and JAS239 was identified as the most promising choline-mimetic with inherent near infrared fluorescence. Attenuation of choline phosphorylation by …
-
Connectivity biomarkers in neurodegenerative tauopathies
… by disease. I investigate simple clinical biomarkers, showing that a two-minute test of verbal fluency is a potential diagnostic biomarker to distinguish between PD and PSP and that the ACE-R and its subscores could play a role in monitoring cognition over time in PD, PSP and CBS. I assess …
-
An Integrated Bioinformatics Approach for the Identification of Melanoma-Associated Biomarker Genes. A Ranking and Stratification Approach as a New Meta-Analysis Methodology for the Detection of Robust Gene Biomarker Signatures of Cancers.
… has facilitated the systematic discovery of diagnostic biomarkers of cancers and other pathologies. However, meta-analyses of published arrays using melanoma as a test cancer has uncovered significant inconsistences that hinder advances in clinical practice. In this study a computational …
-
Characterisation and Detection of P53 Aggregates
… into cancer biology and may lead to novel diagnostic and therapeutic strategies. Previous studies on p53 aggregates mainly focused on the properties of bacteria-derived p53 core-domain fragments, which have different post-translational modifications from human p53 and may behave distinctly …
-
Cell-free DNA and tumor exosome cargo as diagnostic and prognostic marker for prostate cancer
… antigen (PSA) has long been introduced as a biomarker for screening in PCa diagnosis. However, serum PSA has low sensitivity for PCa diagnosis which has led to serious harm such as overdiagnosis and other complications of treatment for indolent disease. This makes it imperative to search for …
-
Common Pathophysiological Features of Charcot-Marie-Tooth Disease
… to be integrated into an online genetic diagnostic platform. Within the clinical trials I identify lack of responsive CMT biomarkers as a major limiting factor for therapeutic trials. Therefore, I next seek to identify novel biomarkers, by applying proteomics in a cohort of CMT patients …
-
From Acute to Chronic: Outcomes and Diagnostics in Traumatic Brain Injury
… and clinicians. The advent of blood-based biomarkers has been an exciting recent development in TBI research, providing objective evidence of the degree of brain injury through a simple blood test, with the potential to aid in both diagnosis and prognostication following injury. This thesis …
-
Expression of Cyclon/CCDC86 Gene in Cells of the Immune and Nervous Systems in Patients with Schizophrenia /// Експресия на гена Cyclon/CCDC86 в клетки на имунна и нервна системи при пациенти с шизофрения
Шизофренията е тежко социалнозначимо заболяване, засягащо около 1% от световното население, без ефективно лечение. Основна причина за това е хетерогенността на заболяването (група от поне 8 заболявания, „шизофрении”), като вероятно в различните групи има различна етиология и патогенеза и съответно …