Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"diabetology"”.
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HEALTH CONSEQUENCES OF URBANIZATION: EFFECTS OF AIR AND ELECTROMAGNETIC POLLUTION ON THE PREVALENCE OF OBESITY, DIABETIC COMPLICATIONS AND OLFACTORY DYSFUCTION IN DIABETIC PATIENTS.
… were analyzed. Each patient underwent standard diabetology evaluation, ENT exam, psychophysical olfactory testing and filled in a questionnaire on olfactory-related quality of life (QoL). Statistical analysis used non-parametric tests and logistic regression. Results The prevalence of diabetic …
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Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide
Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to …
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The clinical characteristics, presentation, and treatment outcomes of prolactinomas at Groote Schuur Hospital
Background: Prolactin-secreting tumours( prolactinomas) are the commonest type of pituitary tumour, accounting for approximately 30 to 40 %% of all pituitary adenomas. Although there is ample epidemiologic and clinic data from Industrialised countries there remains sparse data from Africa. …
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An audit of the thyroid screening programme in the Peninsula Maternal and Neonatal Services
To audit the crod blood thryoid screening programme in the Peninsula Maternal and Neonatal Services (PMNS) in the 5 year period from 01/01/2000 to 31/12/2004, focusing on coverage, recall rate and success, number of cases detected, incidence of congenital hypothryoidism in this population; and cost …
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Quantitative cytochemical studies of acid secretagogue effects on the carbonic anhydrase activity of gastric parietal cell sections
This thesis presents work designed to study the effects of acid secretagogues upon the parietal cell, in order to gain a greater understanding of their modes of action, and interaction and the role of circulating secretagogues in the mediation of parietal cell function, with the aim of increasing …
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Carotid artery intima-media thickness measurement in subjects with type 2 diabetes in Cape Town, South Africa
The aim of this study is to test the hypothesis that, for similar durations of diagnosed diatetes (DM); black South Africans have less atherosclerosis as measured by Carotid Intima Media Thickness (CIMT) than non-black South Africans.
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The diabetic diet : education, compliance and practical applications
The aim of this thesis is to investigate different methods of improving the glycaemic control of diabetic out-patients, within the scope of the author's training both as a therapeutic dietitian and as a teacher. Evidence is presented from the literature, which indicates that high-carbohydrate, …
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Longitudinal study to assess the prevalence of hypogonadism in HIV-infected South African men and its association with bone density, body composition, metabolic abnormalities (dysglycaemia, dyslipidaemia) and quality of life.
Background: Hypogonadism has been described in association with HIV infection and anti-retroviral therapy (ART). Furthermore, hypogonadism is associated with comorbidity and a reduced quality of life. The prevalence of hypogonadism in HIVinfected South African men is unknown. We examined the …
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The control of prolactin secretion and the role of gonadotrophin releasing hormone in the production of concordant secretory spikes of luteinizing hormone and prolactin in the luteal phase of the menstrual cycle
The control of prolactin secretion is a complex interaction of peptides and neurotransmitters acting either in an inhibitory or stimulating way to effect final secretion of this hormone from the lactotrope cell in the anterior hypothalamus. These factors may act either directly on the lactotrope …
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Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes
Autonomic neuropathy (AN) is a well-recognized complication of diabetes mellitus. It has multiple clinical features and is often associated with debilitation and an increased mortality. However, there appears to be a paucity of knowledge with regard to its effects on hormone release and its …
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Retrospective analysis of pregnancies at the Grootte Schuur Hospital : a comparison of pregnancy outcomes in pre-gestational and gestational diabetes
Although the treatment of gestational impaired glucose tolerance (GIGT) has been shown to be beneficial, the cost implications in treating GIGT in resource constrained economies needs examination. Thus this study assessed: (i) pregnancy outcomes in pre-gesational types 1 and 2 diabetes (DM) with …
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Serum somatomedin and somatomedin generation by the perfused liver in protein malnourished rats
The studies presented in this thesis represent an attempt to characterise some aspects of the abnormalities of somatomedin physiology in protein-energy malnutrition. A suitable bioassay to study somatomedin was found in that of Van den Brande and Du Caju (1974) which makes use of uniform discs of …
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Effects of palatable diets on appetite regulation, appetite peptides and neurogenesis.
Obesity is increasing throughout the world at an epidemic rate, partly due to increased consumption of diets rich in fat and/or sugar. Ghrelin and leptin are hormones, originating from the periphery, involved in the regulation of food intake and of maintaining energy homeostasis. Circulating …
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Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion.
We have investigated the role of lipid metabolism with regard to beta-cell function and insulin secretion. Lipids are known to play a crucial functional role in the pancreatic beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to …
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The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose …
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Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP.
Type 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. When insulin resistance develops, the …
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Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease
The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems …
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Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)
Autoimmune diabetes is characterized by cell mediated autoimmunity against insulin producing beta cells in pancreatic islets. Type 1 diabetes is the major cause of diabetes in children and adolescents and is believed to be mediated by a Thl driven destruction of beta cells. The much more prevalent …
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Candidate Genes for Late Diabetic Complications
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The new WHO criteria for classification of diabetes takes into account also clinical stages dividing the diabetic patients into noninsulin …
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THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION
Type 2 diabetes mellitus (T2DM) is characterized by various combinations of ?-cell failure and insulin resistance leading to hyperglycemia and glucose intolerance. In order to maintain glucose tolerance in the insulin resistance state, increased insulin secretion is a requirement and it is because …
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