Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"diabetic kidney disease"”.
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Identification and evaluation of novel biomarkers in diabetic kidney disease
Introduction: Diabetic kidney disease (DKD) is a progressive microvascular complication that leads to a decline in renal function and is the most frequent cause of end-stage renal disease. Currently, there is a need for improved biomarkers for the early detection of DKD. microRNAs (miRNAs) are …
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Understanding experiences of diabetes care among patients with diabetic kidney disease
… perceptions of diabetes care among patients with diabetic kidney disease and is driven by my research question “what are the experiences of diabetes care among patients with diabetic kidney disease?”. In order to achieve this I interviewed ten patients individually from the Hawke’s Bay area and …
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The impact of social deprivation on development and progression of diabetic kidney disease
… to be living with diabetes globally by 2045. Diabetic kidney disease (DKD) develops in up to 40% of people living with diabetes, and significantly increases morbidity and mortality. Social deprivation is well established as a risk factor for poorer health outcomes. Social deprivation is …
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Next Generation Sequencing and Genome-Wide Association Studies to Identify Mitochondrial Genomic Features Associated with Diabetic Kidney Disease
Diabetic kidney disease (DKD) affects ~40% of persons with diabetes and is the leading cause of chronic kidney disease and end-stage renal disease globally. Mitochondrial dysfunction is implicated in the pathophysiology of DKD. Previous research reported SNPs in nuclear genes, which influence …
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Evaluation of genetic variants for Type 2 diabetes associated kidney disease in African Americans
End-stage kidney disease (ESKD) is a significant public health problem in the U.S., disproportionately affecting African Americans (AAs; 1,003 per million/year) at 3.3-fold higher incidence rate than European Americans (301 per million/year), and 2-fold higher than Native Americans (499 per …
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Enhancing the Data, Information and Knowledge from Proteomics Experiments through Biomedical Informatics
A systems approach to understanding disease begins with data that contains information from which knowledge is developed and ultimately provides wisdom and understanding to human health and disease. Systems biology is a fast growing area of research to promote translational medicine and is …
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Phosphodiesterase 1 (PDE1) at the Crossroads of Calcium and Cyclic Nucleotide Signaling in Diabetic Nephropathy
Diabetic Kidney Disease (DKD) is a major complication of diabetes. Incomplete understanding of its molecular mechanisms is highlighted by the limited treatments options. We hypothesized that inhibition of protective endogenous mechanisms plays major role in the pathogenesis of DKD. While …
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Urinary Biomarkers and Patient Outcome in Chronic Kidney Disease and Atherosclerotic Heart Disease: The value of IgM-uria and IgG-uria
Risk stratification of patients with chronic kidney disease and atherosclerotic heart disease is crucial. Microalbuminuria (MA) is associated with an increased risk of kidney and cardiovascular (CV) death, especially in patients with diabetes. However, MA in many instances is not sensitive for …
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Predictive Role of NGAL – Neutrophil Gelatinase-Associated Lipocalin as an Early Marker for Renal Injury in Patients with Diabetes Mellitus Type 1 And Type 2 // Предиктивна роля на NGAL – неутрофил гелатиназа асоцииран липокалин като ранен маркер за бъбречно увреждане при пациенти със ЗД тип 1 и ЗД тип 2
Дисертационният труд разглежда ролята на Неутрофил гелатиназа-асоцииран липокалин (NGAL) като маркер за бъбречно увреждане при пациенти със захарен диабет (ЗД). Съществен принос са определените възрастово и полово диференцирани референтни граници на pNGAL, uNGAL и uNGAL/uCreatinine (UNC) за …