Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"diabetic cardiomyopathy"”.
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
<p>Diabetic cardiomyopathy is a distinct pathological condition characterized by myocardial fibrosis and cardiac dysfunction in diabetic patients. The resolution of myocardial fibrosis to improve cardiac function in diabetes is an active area of research. Notably, increased T lymphocyte …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… diseases account for ~80% of deaths amongst diabetic patients, primarily through coronary artery disease (CAD). However, a new clinical entry, termed Diabetic Cardiomyopathy (DC), may lead to heart failure in diabetic patients independently of CAD or hypertension. In DC, hyperglycemia and …
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Role of PERM1 in the Development of Insulin Resistance and Diabetic Cardiomyopathy During High-Fat Diet Feeding
Heart failure is a leading cause of death in the United States, impacting approximately 6.7 million people. Several comorbidities are associated with heart failure, contributing to adverse clinical outcomes. Among these comorbidities, diabetes is highlighted as a prominent risk factor for heart …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… insulin secretion or action. Up to 75% of diabetic patients die due to cardiovascular complications such as heart failure (HF). The term “diabetic cardiomyopathy” describes distinct structural and functional changes in the heart driven by metabolic and microvascular abnormalities. …
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Extracellular microenvironment for the regulation of endothelial angiogenic responses
… including diabetes-induced myocardial injury (diabetic cardiomyopathy, DCM) and diabetic ulcers. These complications are associated with vascular pathologies such as abnormal angiogenesis (formation of blood vessels) along with altered biomechanical and cellular microenvironment. Vascular …
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Mechanisms of Dysregulated Alternative Splicing in Cardiac and Skeletal Muscle under Diabetic Conditions
Under diabetic conditions, cardiac and skeletal muscle undergoes changes that can lead to cardiomyopathy and myopathy respectively. Diabetes patients suffer from skeletal muscle weakness and atrophy. Diabetic cardiomyopathy can progress into heart failure. Currently, no treatments are available for …
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Novel mechanisms of diastolic dysfunction in diabetes
Diabetic cardiomyopathy is primarily characterised by diastolic dysfunction and deranged cardiomyocyte performance. The underlying mechanisms are unknown, and specific treatment targets are lacking. Recent findings (Mellor et al, publication pending) have shown that glycogen accumulation is a …
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Intracellular calcium mobilization in cardiomyocytes of rats with experimental diabetes
… the mechanism(s) involved in the development of diabetic cardio myopathy, [Ca2]i (determined by fluorescence microscopy and Ca-indicators) and contraction of the cardiomyocytes (measured by a video-edge detector system) were studied in rats with experimental diabetes induced by streptozotocin …
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Increased Mitochondrial Calpain-1 Is an Important Mechanism Contributing to Mitochondrial ROS Generation in Cardiac Diseases
… in mitochondria were significantly elevated in diabetic and septic hearts. The elevation of mitochondrial calpain-1 correlated with an increase in mtROS generation and oxidative damage. Importantly, cardiomyocyte-specific deletion of capns1 disrupted calpain-1 and calpain-2 in the heart and …
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Expression and Regulation of Osteopontin in the Diabetic Heart
… and a direct role for OPN in the progression of diabetic cardiomyopathy to heart failure has been reported.</p><p>The overall objective of this project is to determine if OPN is upregulated in the heart in a model of type 2 diabetes and if OPN is increased in cardiac cells in response to high …
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Diabetes and the Female Heart
… is a major risk factor for heart failure, with diabetic women experiencing disproportionately severe outcomes compared to diabetic men. The mechanisms underlying these sex specific outcomes remain unclear. This thesis investigated how sex and type 2 diabetes interact to influence cardiac …
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The Role of Metabolic Inflexibility in Heart Failure
… to replicate the cellular metabolic profile in diabetic heart to 1) determine if energy deficiency plays a causative role in HFpEF progression, and 2) test the necessity of glucose oxidation for left ventricular hypertrophy development and progression to HF. Since pyruvate dehydrogenase (PDH) …
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Manganese-enhanced magnetic resonance imaging in cardiometabolic disorders
… in patients with subclinical or clinically overt diabetic cardiomyopathy and it has never been used to assess pancreatic functional beta-cell mass in patients with type 1 diabetes. The aims of this thesis were 1) to assess the reproducibility and repeatability of manganese-enhanced magnetic …
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High-field Cardiac Magnetic Resonance Imaging in Small Animal Models of Cardiovascular Disease
… (MI), pulmonary hypertension (PH), and cardiomyopathy belong to a class of diseases collectively described as cardiovascular disease, the leading cause of death worldwide. Assessment of the left and right ventricular (LV, RV) structural and functional changes concomitant with the …
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Cardiovascular Effects of GLP-1 and Glucagon Dual Receptor Agonism in Humans
… and sulfonylureas). A wealth of new anti-diabetic agents have emerged over the past two decades including dipeptidyl peptidase IV inhibitors, glucagon like peptide-1 (GLP-1) receptor agonists and selective sodium-glucose transporter-2 inhibitors (SGLT2i). These medications have transformed …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… to severe long term complications including cardiomyopathy, nephropathy, retinopathy and neuropathy that are common in type 1 DM (T1DM) and type 2 DM (T2DM). Epidemiological studies have demonstrated a role of hyperglycaemia (HG) in eliciting adverse cardiac and renal outcomes including heart …
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Cellular mechanism of contractile dysfunction in diabetes-induced cardiomyopathy
… in the streptozotocin-induced (type 1) diabetic cardiomyopathy compared to age-matched control heart. Human and animal studies have shown that diabetes mellitus can be associated with altered cardiac function that is independent of vascular complications. The effects of increased …