Global ETD Search
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Showing 1 to 3 of 3 for “"dhx36"”.
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G4-RESOLVASE 1 TIGHTLY BINDS AND CATALYTICALLY UNWINDS UNIMOLECULAR G-QUADRUPLEX STRUCTURES WITH IMPLICATIONS FOR GENE TRANSCRIPTION AND TELOMERE BIOLOGY
… It has been previously shown that the DHX36 gene product, G4-Resolvase1 (G4R1), binds parallel tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here we show that G4R1 specifically binds to a parallel, unimolecular G4-DNA with remarkable …
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Unveiling Global Roles of G-Quadruplexes and G4-22 In Human Genetics
… G4 structures are efficiently resolved by the DHX36 helicase. G4-22 was found mainly within introns, away from splice sites, and PANTHER analysis indicated that G4-22-containing genes are specifically enriched in GO terms related to the brain and nervous system.<strong> </strong>These findings …
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The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination
<p>B cells alter the expression of immunoglobulin isotypes through a process known as class switch recombination (CSR). In these cells, activation induced cytidine deaminase (AID) binds Gquadruplex (G4) switch transcripts, which serve as guide RNAs to target AID to the immunoglobulin heavy chain …