Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"dextran sulfate sodium"”.
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Elevated colorectal cancer risk in the hnRNP I knockout mice treated with azoxymethane/dextran sulfate sodium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Inflammation enhanced colon cancer & natural anti-cancer plant compounds
… inflammation-enhanced colon cancer, using the dextran sulfate sodium/ azoxymethane mouse model. GKB (500 µmol/kg diet daily), GE (providing an equal dose of GKB) and broccoli protected against some aspects of inflammation, including cyclooxygenase-2 levels in colonic mucosa. The extract and the …
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Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice
… After inducing colitis in a mouse model using Dextran Sulfate Sodium (DSS), prebiotics inulin and oligofructose enriched inulin (OEI) were used as treatments to determine their effects on the gut microbial community, physiological healing process, and immune response in the mice after initial …
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A Larval Zebrafish (Danio Rerio) Model of Adherent-Invasive Escherichia Coli Infections
… AIEC delivery to the gastrointestinal tract, and dextran sulfate sodium (DSS) pharmacologically induced colitis. AIEC colonized the zebrafish gut in higher numbers and persisted for longer compared to non- pathogenic E. coli in the absence of chronic inflammation. Further, bacterial burden and …
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Determining the impact of Heligmosomoides polygyrus infection on the development of colitis
… models of human disease, the oxazolone and dextran sulfate sodium (DSS) models, I found that induction of murine IBD is highly sensitive to diet change and mouse gender. Using the gastrointestinal helminth Heligmosomoides polygyrus (H.polygyrus), I demonstrate that helminth infection …
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Effect of Coconut Oil on Ulcerative Colitis in the Mouse Model
… female C57BL/6 mice by exposing them to 2.5-3% dextran sulfate sodium (DSS) for 5 and 29 days in the acute and chronic models, respectively. Coconut oil treatment was given via food containing 5% coconut oil to three diseased groups in three different regimens: one, preventive group receiving …
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A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
… pro-nociceptive mechanisms, acute and chronic dextran sulfate sodium (DSS) mouse models of colitis were established and substance P (SP; marker of nociceptor terminals) immunohistochemistry used to investigate changes in immunoreactivity of DRG terminals in the thoracic dorsal horn (segments …
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Non-Psychotropic cannabinoids attenuate visceral pain in colitis
… visceral hypersensitivity use the acute dextran sulfate sodium model. Abdominal pain was quantified by electromyographic recordings of the reflexive contraction of the external oblique muscle in response to colorectal distension using an animal of experimental colitis. Activation of the …
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Colonocyte-Derived Lactate Promotes Enterobacteriaceae Fitness During Non-Infectious Colitis
… the antibiotic streptomycin, a low dose of dextran sulfate sodium (DSS), or both together. In this way, we demonstrated that both inflammation and dysbiosis together were required to induce a maximal production of lactate and for E. coli to utilize lactate. With a genetic mouse model lacking …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… and the immune system was investigated in the dextran sulfate sodium induced UC mouse model. We demonstrated changes in the colonic intestinal microbiota pattern and immunological alterations of different populations of T cells, dendritic cells and natural killer cells after UC induction.
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Improving sulforaphane bioavailability from cooked broccoli
… of CB and raw broccoli (RB) in prevention of dextran sulfate sodium (DSS)-induced colitis in mice. Our data show that frequent intake of a CB diet is as effective as a RB diet in lessening damage by DSS, evidenced by a decreased disease activity index, attenuated colon length shrinkage, less …
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Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… stress, we exposed WT and Il15-/- mice to dextran sulfate sodium (DSS), a chemical irritant that disrupts the intestinal epithelial barrier and results in induction of colitis. Mice deficient in Il15 did not display a decreased susceptibility to acute DSS-induced colitis. Additionally, we …
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Molecular Mechanisms of American Ginseng For the Prevention and Treatment of Colitis and Colon Cancer Associated With Colitis
… (Chapter IV). Using the azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model of UC, we show that AG can suppress colon cancer associated with colitis. To explore the molecular mechanisms of the anti-cancer effects of ginseng, we also carried out antibody array experiments, and found …
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AKR1B8 IS A NOVEL MODULATOR OF CRYPTIC SELF-RENEWAL AND SUSCEPTIBILITY TO COLITIS AND ASSOCIATED CANCER
… were highly susceptible to colitis induced by dextran sulfate sodium at a lower dose (2%) and demonstrated severe liquid diarrhea and gross bleeding. Histopathologically, AKR1B8 -/- mucosa had drastic inflammatory cell infiltration, ulceration and fiber deposits; injury repair of epithelium was …
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Effects of yeast products on immune response and intestinal health of dogs and mice
… gene expression and colonic histopathology in a dextran sulfate sodium (DSS)-induced colitis model. Fifty-four 6-week-old male C57BL/6J mice were assigned to one of three treatment diets (n = 18/diet): 1) AIN93G diet (control); 2) control diet + 5% SCFP; or 3) control diet + 5% psyllium husk …
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Protective Role of Mesenchymal MyD88 Signaling Under Homeostasis and Initiation of Inflammation in the Colon
Intestinal Mesenchymal stromal cells (fibroblasts, myofibroblasts and their progenitors) have recently emerged as key players in the interplay between the microbiota and professional immune cells under homeostasis and chronic inflammation. Initiation of microbial interactions with host cells, …