Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"dextran sodium sulfate (DSS)"”.
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Investigating a Mitochondrial Fission Inhibitor as a Therapeutic for Inflammatory Bowel Diseases
… in a mouse model of IBD, chemically induced by dextran sodium sulfate (DSS). Treatment with P110 was found to reduce macroscopic symptoms of colitis and provides evidence that aberrant mitochondrial dynamics contribute to IBD. The results provide motivation for further investigation into the …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… of CFTR and iNOS activity attenuates diarrhea in dextran sodium sulfate (DSS) induced colitis. Dissolution of the macromolecular complex in Nherf2 -/- mice renders them resistant to CFTR-mediated secretory diarrhea in murine colitis models compared to Nherf2+/+. Our findings have important …
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A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… damage in these mice by orally administering dextran sodium sulfate (DSS) and found mutations that led to diarrhea and weight loss under these conditions. Causative mutations were mapped concurrently with screening using an automated mapping procedure. Among 114 DSS phenotypes identified and …
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Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: Importance of peroxisome proliferator-activated receptor γ expression
… study, we investigated the suppression of dextran sodium sulfate (DSS)-induced colitis by dietary sphingomyelin in mice that lack functional peroxisome proliferator-activated receptor γ (PPAR-γ) in intestinal epithelial and immune cells. Dietary spingomyelin decreased colonic inflammation …
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Impact of Epa and Dha Supplementation and 15-Lox-1 Expression On Colitis and Colitis-Associated Colorectal Cancer
… prevent colitis and CAC. Mice were treated with dextran sodium sulfate (DSS) alone only to induce acute and chronic colitis, or with DSS following an azoxymethane injection to induce CAC. In the chronic colitis model, DHA diet and/or expression of 15-LOX-1 reduced inflammation and altered immune …
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Mechanisms of Induction and Maintenance of Constitutive Ptgs2 Expression in Colonic Mesenchymal Stem Cells
… model injury systems: administration of dextran sodium sulfate: DSS) and colonic biopsy. The central role of Ptgs2-expressing cells in injury demonstrates the importance of understanding Ptgs2 regulation. We therefore created a robust in vitro system for studying the pathways and …
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Intestinal Inflammation Model Inducing Gut Leakage by Different Methods in Broiler Chickens Using FITC-d as a Marker
… administration of fluorescein isothiocyanate dextran (FITC-d) and its passage into blood can be used as a marker for tight junction permeability. FITC-d is a large molecule (3-5 kDa) which does not usually leak through the intact gastrointestinal tract barrier. However, when conditions disrupt …
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Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2
… studies were performed using a mouse model of dextran sodium sulfate (DSS)-induced colitis. In Chapter 4 of the dissertation, we developed a novel integrated approach for creating a synthetic patient population and testing the efficacy of the novel pre-clinical stage LANCL2 therapeutic for …
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Investigating the role of IgG and Fcγ receptors in intestinal inflammation
… inflammation. We found that UC and murine dextran sodium sulfate (DSS)-induced colitis are associated with a significant increase in anti-commensal IgG and local enrichment of FcγR signalling pathway genes. The genes most robustly correlated with FCGR2A, an activating FcγR associated with …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… VSG in mice and chemically induced colitis with dextran sodium sulfate (DSS) three weeks after surgery (Chapter Four). The present dissertation describes the contributions of β-cell GLP-1R signaling in the glucoregulatory benefits of VSG surgery; demonstrates β-cell GLP-1R signaling is a novel …
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The effects of treadmill and voluntary wheel training on morbidity and inflammation during ulcerative colitis in mice
… effects on morbidity and inflammation in a dextran sodium sulfate (DSS)-induced colitis model in C57Bl/6J mice. We hypothesized that FTR and VWR would improve indices of morbidity and inflammation during colitis. We observed the effects of DSS-induced colitis during a recovery study as mice …
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Inhibitory potential of anthocyanins and anthocyanin-rich extracts on colorectal cancer progression through apoptosis, angiogenesis, and immune response effects
… D3G-enriched extract on azoxymethane (AOM) and dextran sodium sulfate (DSS) induced colitis-associated carcinogenesis. The black lentil group had a lower disease activity index throughout and at the end of 2.4 compared to 6.3 of the AOM/DSS control (p<0.05). Mice in the black lentil group had an …
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Effects of potato fiber and soluble corn fiber on the fecal microbiome of dogs with implications to inflammation
… in attenuating the inflammatory response in the dextran-sodium sulfate (DSS)-induced colitis mouse model. We hypothesized that a moderately fermentable PF would be more effective at attenuating the symptoms and inflammatory response in DSS colitis than non-fermentable cellulose (Cell). Mice …