Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"developmental toxicity"”.
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Developmental Toxicity of Organophosphate-Based Flame Retardants
… concerns about persistence, bioaccumulation, and toxicity, PentaBDE was voluntarily phased out, prompting an industry-wide shift toward the use of alternative flame retardant formulations containing at least one of the two major classes of organophosphate-based flame retardants (OPFRs) - …
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Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
… a newly established critical window of postnatal developmental sensitivity for female-specific microglial maladaptation. Collectively, this set of experiments provides insight into the potentiative effects of GxE during development and neuroimmune-related susceptibility to AD.
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Analytical Tools for Characterizing Developmental Toxicity of Environmental Chemicals Using High-throughput Screening in Zebrafish (Danio rerio).
North Carolina State University Theses Bioinformatics.
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Light Enhanced Toxic/tumorigenic Potential of Trinitrotoluene (Tnt) and Analogs
The acute toxicity of TNT, 2-amino,-4,6-dinitrotoluene (2A) and 4-amino,-2,6-dinitrotoluene (4A) to Photobacterium phosphoreum (Microtox reagent), Daphnia magna (daphnia), and Dugesia dorotocephala (planaria) was enhanced by near-ultraviolet light (nUV) coexposure. The light enhanced toxicity of …
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Machine learning in predictive toxicology: investigating developmental and reproductive toxicity with transfer learning
The toxicity of a compound has always been a major concern in risk assessments of new products or drugs. In the field of predictive toxicology, with animal testing being phased out in some sectors, there is an urgent need for alternative methods for determining toxicity. An *in silico* method such …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… limits are designed to prevent acute neurotoxicity in adult humans. However, research shows that low-level exposure during early life can lead to long-term changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this …
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Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
… remain in our understanding of its sex-specific toxicity and heritable effects across generations. This thesis investigated the multigenerational cognitive and reproductive toxicity of chronic dietary arsenic exposure in zebrafish (Danio rerio), with a focus on sex-specific susceptibility, …
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Characterizing the Developmental and Reproductive Toxicities of Cannabidiol and Δ9-Tetrahydrocannabinol
… and multigenerational toxicities following a developmental F0 exposure to 0.024–5 mg/L (0.08–16 µM) THC or 0.006–1.2 mg/L (0.02–4 µM) CBD. In this study, THC was used as a positive control due to its established developmental toxicities. An additional goal of this project was to analytically …
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Regulatory issues concerning the preclinical testing of synthetic peptides
… components that are already tested for genotoxicity, it is unnecessary to reevaluate them. If such information can be shared with sponsors ahead of the IND application, it can save time and money. There is no research that evaluated the FDA’s views on pre-IND consultation. Therefore, through …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… limits are designed to prevent acute neurotoxicity in adult humans. However, research shows that low-level exposure during early life can lead to long-term changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this …
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Synthesis and Evaluation of Naturally Occuring Halogenated Bipyrroles in a Relevant Marine Species, Fundulus Heteroclitus
… have also focused our efforts on examining the developmental toxicity in a marine relevant species, Fundulus heteroclitus. We measured also the induction of the cytochrome P4501A (CYP1A) gene through activation of AhR signaling pathway by HDBPs. Fundulus are considered to be the "premier teleost …
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Combined effects of bioavailable organic contaminants in the aquatic environment.
… overcome many of the challenges associated with toxicity testing of hydrophobic substances, which can bias the interpretation of toxicity data. The present study investigated the feasibility of coupling silicone rubber passive sampling devices (SR-PSDs) with bioassay techniques for both chemical …
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Anti-Ecdysteroidal Activity and Associated Toxicity of Environmental Chemicals in the Crustacean Daphnia magna.
… Daphnia magna. The molting effect and embryotoxicity of fenarimol were abrogated by co-exposure to exogenous 20-hydroxyecdysone. These experiments demonstrated that ecdysteroids are critical to normal embryo development and chemicals that lower ecdysteroid levels induce developmental …
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Characterising the functional homology of central nervous system drug targets in larval zebrafish (Danio rerio)
… which currently rely largely on apical toxicity endpoints and consider pharmacological mode of action to a lesser degree. This thesis investigates whether conservation of CNS drug targets in fish predicts functional effects, using larval zebrafish (Danio rerio) as a model system. The …
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Understanding the impacts of antipsychotic pharmaceuticals on behaviour in fish
… Broad screenings identified clear differences in developmental toxicity, with quetiapine emerging as the compound of greatest concern, exhibiting the lowest sublethal no-observed-effect concentration (NOEC), one order of magnitude below its lethal threshold (NOEC). Liquid chromatography-tandem …