Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"developmental time"”.
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Comparison of the molecular phenotypes of pigs carrying different IGF2 alleles at four developmental time points
… each genotype (Apat and Gpat) at four different time points, fetal day 90 (d90), birth (0d), weaning (21d), and market weight (176d). In total 46 samples were sequenced on the Illumina HiSeq 2000 with a target depth of 20 million reads per sample. Analysis of the RNA-seq data using tweeDEseq …
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The Role of Resilience in Sexual Assault Revictimization
… of multiple victimizations, particularly across developmental time periods. This study examined the relationship between victimization across developmental time periods, resilience factors (emotion regulation, mindfulness, adaptive coping), and PTSS severity. We analyzed a sample of 503 cisgender …
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The Role of Octopamine in the Regulation of Division of Labor in Honey Bee Colonies
… be regulated. Because juvenile hormone acts over developmental time scales to affect foraging while octopamine acts over short-term scales, I investigated whether octopamine is downstream of juvenile hormone in the regulation of foraging. Results from this chapter suggest that octopamine acts …
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Developmental Single-Cell RNA Sequencing in the Sea Urchin Species Lytechinus variegatus and Heliocidaris erythrogramma
… what remains unclear is how a highly conserved developmental GRN can change over evolutionary time and how that can result in altered embryonic form and function.To begin to understand these processes, we developed methods to compare two relatively simple, yet complex sea urchin embryos with …
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IMPROVING THE LONGITUDINAL ASSESSMENT OF ADHD IN PEDIATRICALLY AND PSYCHIATRICALLY REFERRED SAMPLES
… expression of symptoms and impairment due to developmental changes from childhood to adolescence and adulthood. Actual diagnostic practices may also differ from recommended best practices. These challenges have led to the proliferation of several clinical guidelines, many of which recommend …
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Poison frog warning signals: From the rainforest to the genome and back again
… Finally, I examine gene expression during developmental time periods that correlate with color deposition to examine how candidate color genes influence color production over developmental time and across multiple color morphs.
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Factors Promoting Variation in Feeding Morphology of Larval Southern Toads (Bufo Terrestris)
… morphology, denticle length, size, and developmental time of B. terrestris raised in three different shade environments. Linear and geometric morphometrics were used to quantify chondrocranial morphology for a group of specimens representing a range of ontogenetic stages, and for …
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Growth Differentiation Factor 11 Promotes Survival of Mouse Retinal Ganglion Cells in Vitro through Smad2/3 Activation
… cells (RGCs) to grow dendrites in vitro. The developmental expression pattern of GDF11 in RGCs and the impact of GDF11 on mammalian RGCs remain unknown. The current study investigated 1) the developmental time course of GDF11 expression in RGCs, 2) the effect of GDF11 on RGC survival and …
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Tissue and Cell-Type Localization and Partial Characterization of a Xylem Papain-Type Cysteine Protease From Arabidopsis
… using purified XCP1H6. Immunoblot analysis of a developmental time course of xylem and bark protein extracted from root-hypocotyl segments demonstrated that XCP1 was expressed in xylem only. Further analysis under optimized immunoblot conditions, however, revealed that anti-XCP1 antibody reacted …
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… (WT) and nNOS-/- mice at different postnatal developmental time points. This study revealed that there are gene- and sex-dependent differences in GABA concentration in the cerebellum during early postnatal development. Additionally, there is decreased EAAT4 expression in male nNOS-/- mice. …
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Transdiagnostic Approaches to Neurodevelopment
Neurodevelopmental difficulties can have a substantial impact on children’s lives and often have lasting effects in adult life. The scientific study of the causes and consequences of neurodevelopmental difficulties has arguably been slowed by the overreliance on case-control designs, which fail to …
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Probabilistic Dynamical Modelling of Spatiotemporal Cell Trajectories During Neural Development
… patterns in Cajal-Retzius cells across developmental time and cortical regions.
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Comparative embryology and muscle development of polyclad flatworms (Platyhelminthes: Rhabditophora)
… an interesting and useful group for research in developmental biology. Although polyclads, together with catenulids and macrostomids, have been argued to be most closely related to the ancestral flatworm and hold the key to understand the relationship between development and evolution, knowledge …
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Identification of cellular signaling events dysregulated in Huntington’s disease.
… 298 peptides b) R6/2 HD mouse model across key developmental time points using customized arrays with 1268 peptides. In an effort to investigate disease-associated changes in signal transduction activity, global patterns of kinase activity (kinome analysis) were characterized within a NSC line …
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Connectivity of dI3 Interneurons In the Development of Mice Spinal Cord
… aim of the study focused on determining the developmental time point at which the PGR disappeared. Our studies demonstrated that the PGR was lost by the third week of development. The second aim of this study focused on identifying changes in sensory innervation, presynaptic inhibition and …
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Molecular Mechanisms Regulating Fate Determination of Cerebral Cortex Precursors
… gliogenic signals until the appropriate developmental time point for astrogenesis, providing one mechanism whereby precursors integrate conflicting environmental cues. A Noonan Syndrome (NS)-associated activated SHP-2 mutation causes perturbations in neural cell genesis, which may …
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Social life-styles in caterpillars: Behavioral mechanisms and ecological consequences
… social thermoregulation, larval communication, developmental benefits, and advantages of survival are presented to contribute to a better understanding of the evolution and maintenance of social systems in caterpillars. I put the main emphasis of this work on the highly social, tent building …
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The time(s) of our lives: Exploring and opening up alternative temporalities through the experience of disability
… study was to understand how some relate to time atypically and how, precisely through that relation, they help to disclose possibilities for alternative ways of being more generally. Both the COVID-19 pandemic as well as increasing threats of climate change have engendered an appreciation of …
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Circulating sex hormone levels in rats: a systematic analysis of the literature and perinatal BPA study
… to other studies that have examined this developmental time point. The current contradictory nature of the literature regarding the effect of environmentally relevant dosages of BPA could benefit from an examination of the factors other than toxicant exposure leading to the different …
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Identification of CaMK-II Protein Targets in Tissue Culture and Zebrafish Embryos using Tandem Mass Spectrometry
… of CaMK-II which are responsible for specific developmental fates remains a key step in understanding this important protein kinase family. In this thesis research, specific “substrate-trapping” mutants of CaMK-II were designed, introduced into a variety of rodent and human cell lines in …
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