Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"developmental programming"”.
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A murine model of developmental programming of atherosclerosis
… of the mechanisms responsible for the observed programming effects. In-vivo activity and blood pressure measurements and vascular reactivity experiments in 4-month old animals did not demonstrate significant differences among study groups. No marked variation in serum cholesterol levels among …
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Effects of prepartum supplement level and age of weaning on dam performance and developmental programming of male progeny
… early weaning, may have an additive effect on developmental programming.
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Interactions of Early-life Temperature Exposure, Offspring Genotype and Maternal Care on Later-life Maternal Care Provisioning in Female Rats
… the biological mechanisms underlying the developmental programming of maternal care, the mechanisms that link maternal care received to alterations in the dopaminergic and oxytocinergic systems in the offspring remains to be an active area of research. Previous work has studied the …
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Assessment of learning potential using a modified version of the coloured progressive matrices
… could be used to aid in the selection of peers, developmental programming decisions, and provide prescriptive information about the most efficacious modes of learning for an individual.
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Influence of Early Life Stage Hatchery Enhancement Practices on Maternal Reproductive Investment in Coho Salmon (Oncorhynchus kisutch)
… be tied to early life-history conditions through developmental programming, creating the potential for mismatches between hatchery-origin reproductive phenotypes and the demands of natural environments. I quantified maternal reproductive traits in 171 mature female Coho Salmon (Oncorhynchus …
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The avian maternal environment: Its influence on the physiological mechanisms contributing to progeny production efficiency in chicken meat birds
… phenotypic alterations, a phenomenon termed developmental programming. Developmental programming has enormous potential in the chicken meat industry due to meat chickens now spend ~40% of their life in-ovo, the stressors encountered by breeder hens throughout production that can affect the …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
<p>Developmental programming of health and disease correlates the adverse intrauterine environment and the risk of disease later in life as cardiovascular disease, metabolic diseases, renal dysfunction or neurobehavioral disorders among others. Maternal hypoxia is one of the most common …
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Role of oocyte-secreted factors in prevention of cumulus cell apoptosis and enhancement of oocyte developmental competence.
… by OSFs may in turn contribute to oocyte developmental competence. The aim of this thesis was to examine whether cumulus cells exhibit a low incidence of apoptosis due to their close association with oocytes and their exposure to OSFs, and to investigate if OSFs have a direct influence on …
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Programming of the paternal nucleus for embryonic development
… on identifying the molecular determinants of developmental programming of sperm. First, the development of embryos derived from sperm and spermatids, immature precursors of sperm was compared. Sperm-derived embryos developed significantly better than spermatid-derived embryos. Further research …
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The Role of Mouse Placental Endocrine Function on Offspring Metabolic Health
… such as gestational diabetes mellitus (GDM). The Developmental Origins of Health and Disease (DOHaD) theory suggests that adversity in prenatal and early life, influence offspring health. Multiple studies have now shown that the maternal environment (GDM, diet and stress) can affect placental …
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The effect of maternal nutrition on offspring gene regulation via epigenetic modulation
Maternal nutrition during pregnancy is an important intrauterine factor that results in persistent alteration of the offspring epigenome and associates with health outcome later in life. Both DNA methylation and histone modifications have been reported in a range of rat tissues including liver, …
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Exploring the sex-specific programming of cardiovascular disease by maternal obesity and assessing potential interventions to the mother
… obesity on the fetal heart may contribute to the programming of altered cardiac structure and function in later life, though the precise mechanisms for this remain to be determined. In Chapter 5, it is shown that maternal obesity resulted in fetal, but not placental, hypoxia at e13.5 in both …
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An investigation into whether an exercise intervention during pregnancy can prevent the programming of cardiovascular disease in the offspring of obese mothers
… aim of this thesis was to characterise potential programming factors in the obese mother and identify those that were targeted by a treadmill exercise intervention. Through feeding of an obesogenic diet, dams became heavier, with increased fat mass, and showed insulin resistance at weaning. …
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Aggressive Behavioral Phenotype in Intrauterine Growth Restricted (IUGR) Baboons Exposed to Moderate Nutrient Restriction Early in Development
The thrifty phenotype hypothesis proposes reduced nutrition alters the trajectory of development of metabolic regulatory systems to produce a phenotype better fitted to an environment of decreased later-life nutrient availability. Because organisms have physiological mechanisms for coping with poor …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… a prospective molecular mediator of metabolic reprogramming in hearts of obese-exposed adult male mice were assessed in vitro. miR-15b-5p-transfection of H9c2 cardiac myoblasts resulted in lower cellular viability and heightened sensitivity to OMM permeabilisation, suggestive of apoptotic …
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The effect of maternal obesity/GDM and metformin intervention on maternal, placental and fetal health
In many populations worldwide over 50% of women have a body mass index above 25. Therefore, an increasing number of women enter pregnancy overweight or obese. This increases the risk for pregnancy complications such as Gestational Diabetes Mellitus (GDM). Placental function is often affected in …
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Maternal Obesity During Pregnancy: Cardiovascular Outcomes for Mother and Baby
… obesity *in utero*. This forms part of the Developmental Origins of Health and Disease (DOHaD) hypothesis, which states that exposure to suboptimal environments during development programmes changes in long-term health. Together, this shows that maternal obesity during pregnancy is …
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Fetal programming in cattle: the effects of varying maternal protein intake in adolescent beef heifers on fetal and postnatal growth and development of the calf
… in birth weight does not preclude that developmental programming of the structure and/or function of the fetal organs and tissues has already occurred following nutritional stress in early gestation. On the contrary, prior studies have shown that birth weight is not a satisfactory …
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An Examination of Maternal Contributors and Potential Modifiers of Fetal Growth in Pregnancy
… to play, in the child, a vital role in the developmental origins of obesity and other cardiometabolic diseases later in life. Therefore, we initially examined existing literature on the role of maternal obesity and its link to pediatric obesity and documented the known underlying …